Biomedical subjects

K Chandler

Publications and source records attributed to K Chandler.

21 records · Page 2Linked to original sources

PubMed1991

A novel transcellular transport pathway for non-bile salt cholephilic organic anions.

Non-bile salt cholephilic organic anions comprise a single class of nonhomologous ligands having a range of hydrophobicity. Hydrophobicity enhances the hepatic extraction of cholephiles as well as their partitioning into secreted biliary lipid particles. When hydrophobicity is correlated with patterns of biliary excretion for studying transcellular transport, however, the more hydrophobic probes are unsuitable. Specifically, with the isolated perfused rat liver technique, the excretory times for sulfobromophthalein and rose bengal were significantly longer compared with that for the much more hydrophilic analogue phenol red (PR), which showed only a single, nearly symmetrical excretory peak at 10 min. Colchicine affected the apparently well-defined PR pathway only at a saturation dose (10,000 times the tracer dose). In contrast, the effect of a different perturbant, monensin, was striking at a tracer dose of PR, but was less evident at a saturation dose. The combined administration of colchicine and monensin had no additive inhibitory effect on PR excretion at tracer doses. At a saturation dose of PR, where monensin is less inhibiting, however, a significant additive inhibitory effect was observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1985

The perceptual priming phenomenon in amnesia.

Alcoholic Korsakoff patients and controls were given three variants of a priming task. In the first task, a study list of words was followed by a recognition test phase and then a perceptual identification test phase. In the second task, the order of the two test phases was reversed. The amnesics performed like normals on the priming for identification task and the delay did not affect their performance. However, recognition by amnesics was significantly impaired when the delay was introduced; although it too was normal with no delay. In a third task, pseudowords were used as stimuli. Under these conditions the amnesics could not be primed nor could they recognize the material. The implications of these findings for current theories of amnesia were discussed.

Alcohol Amnestic Disorder↗

PubMedDate not supplied

Syringohydromyelia in Cavalier King Charles spaniels.

Syringohydromyelia secondary to foramen magnum overcrowding is described in seven Cavalier King Charles spaniels. Clinical signs were consistent with a central spinal cord lesion. The most common signs were persistent scratching at the shoulder region with apparent neck, thoracic limb, or ear pain and thoracic limb lower motor neuron deficits. The diagnosis was made by magnetic resonance imaging. The syringohydromyelia is postulated to be a consequence of an occipital bone malformation resulting in a small caudal fossa and cerebellar herniation. Clinical signs improved but did not completely resolve when the dogs received treatment with corticosteroids or nonsteroidal anti-inflammatory drugs.

Animals↗