Lipoid proteinosis (Urbach-Wiethe syndrome) with dwarfism.
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Biomedical subjects
Publications and source records attributed to K Chakrabarti.
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The sizes of the anterior fontanel were measured for 110 hilly and 130 non-hilly newborns in and around the District of Darjeeling to observe for any significant difference. The mean size of the anterior fontanel for the hilly newborns was 3.35 +/- 1.07 cm and for the non-hilly newborns was 3.80 +/- 1.95 cm. There was a significant difference (p less than 0.05) between the hilly and non-hilly races. Percentile grids for the mean anterior fontanel size were calculated. This study may help to prepare a national standard for the anterior fontanel size.
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The intestinal transfer of different tetracyclines dissolved in calcium- and magnesium-free Krebs bicarbonate buffer solution, pH 7.4, was studied using the everted ileum of the mouse. The rates of transfer of chlortetracycline and demethylchlortetracycline were less than those of tetracycline and oxytetracycline, the latter compounds being transferred at the same rate. Addition of calcium and magnesium to the buffer greatly reduced the transfer of tetracycline; this inhibition could be antagonized by EDTA. The presence of iron also inhibited the transfer of tetracycline. The inhibitory effect of these ions on tetracycline transfer seemed due to chelation of the drug. Glucosamine and acetylmethionine, but not acetyl glucosamine, diminished the intestinal transfer of tetracyclines. The former two agents did not influence the uptake of tissue fluids. Tetracycline was also transfered from the serous to the mucous coat in the non-everted intestinal sac of mice. The above observations suggested that the absorption of tetracyclines was not due solely to passive diffusion.
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