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Biomedical subjects

K Carey

Publications and source records attributed to K Carey.

30 records · Page 2Linked to original sources
PubMed1986

A survey of homeless adults in urban emergency shelters.

Following a review of several studies of homeless populations, the authors describe a survey of 68 homeless adults in eight urban emergency shelters in Hennepin County, Minnesota. The results indicated impressive rates of mental illness, alcoholism, minor criminality, and chronic medical and dental problems. More significant, the authors believe, both for the homeless and for public policy planners, is that a majority of the interviewees were disconnected from supportive social networks and were underutilizing medical and welfare programs for which they were eligible. Almost 40 percent of those with chronic health problems were receiving no medical care, and only 6 percent were receiving mental health services, although more than 50 percent needed such care. The authors compare the findings with those of studies discussed in the literature review.

Adult↗
PubMed1985

The extent of long-term moderate drinking among alcoholics discharged from medical and psychiatric treatment facilities.

To assess the frequency of an evolution to stable moderate drinking among alcoholics coming to medical or psychiatric treatment facilities, we examined the five- to seven-year outcome for 1289 diagnosed alcoholics treated in our facilities during a two-year period (between 1973 and 1975). We obtained data from personal interviews, records, or both for 83 per cent of the sample. Only 1.6 per cent of the subjects met our definition of stable moderate drinking at follow-up, 15 per cent had become totally abstinent, and 4.6 per cent were mostly abstinent with occasional drinking. The only predictors of moderate drinking that we found were female sex and less severe alcoholism. The evolution to stable moderate drinking appears to be a rare outcome among alcoholics treated at medical or psychiatric facilities.

Adult↗
PubMed1983

Discriminating borderline disorder from other personality disorders. Cluster analysis of the diagnostic interview for borderlines.

The statistical technique of cluster analysis was applied to 252 hospitalized patients' scores on the 29 statements of the Diagnostic Interview for Borderlines. We found that this statistical treatment could reliably differentiate borderline disorder from other personality disorders. Two subtypes similar to Spitzer's schizotypal and unstable subtypes emerged.

Borderline Personality Disorder↗
PubMed1982

Are there borderlines in Britain? A cross-validation of US findings.

This study extends the series of investigations of the borderline concept to a British inpatient population. It compares patient's ratings and diagnoses according to DSM-III, the international Classification of Diseases, ninth version (ICD-9), Gunderson's Diagnostic Interview for Borderlines (DIB), and Minnesota Multiphasic Personality Inventory data. A subpopulation of British inpatients was identified by DIB and DSM-III borderline criteria. All were given ICD-9 personality disorder diagnoses by their British consulting psychiatrists. The date support the concept of borderline personality disorder in the sense that there is a significant level of agreement between the DIB and DSM-III diagnoses, but the clinical and psychometric differentiation of borderline from other types of personality disorders, as well as the interrelationship between the borderline personality disorder and a concomitant depressive state, remain to be demonstrated before the validity of the borderline concept is established.

Adolescent↗
PubMed1981

In-patient community meetings: problems and purposes.

The role of the in-patient community meeting is discussed in relation to the general difficulty of attributing specific effectiveness to any type of therapeutic activity on an in-patient service. Close scrutiny of such units demonstrates that staff and patients are composed of several heterogeneous subgroups, not all of whom share common attitudes and values or benefit from similar activities. Within this framework the major problems as well as functions of the community meeting are discussed. Specific questions which await investigation with clinical research are elaborated.

Attitude of Health Personnel↗
PubMed1978

Circulating immune complexes in Hodgkin's disease.

Levels of circulating immune complexes (CIC) in the serum of patients with Hodgkin's disease were measured by the Raji cell radioimmunoassay. Elevated levels of immune complexes (mean value of 49 microgram/ml +/- 21 SE) were detected in 20 of 40 (50 per cent) untreated patients. After treatment, the level of CIC was normal (less than 15 microgram/ml) in 39 of 41 patients. Recurrent disease developed in two of the 39 patients with normal post-treatment levels of CIC and in one of the two patients with elevated post-treatment levels during the follow-up period of six months to six years. Elevated levels of CIC were detected in patients with Hodgkin's disease in stages I, II and III but not in stage IV. No significant correlations were found in the frequency of elevated levels of CIC or the values observed, and the presence or absence of symptoms (fever, sweats, weight loss) or the histologic subtype of the tumor. Our data indicate that the measurement of CIC by the sensitive and specific raji cell assay may prove useful in the management of patients with Hodgkin's disease. In particular, serial measurement of the level of CIC could be employed to monitor the response to treatment and to detect recurrent diseases.

Antigen-Antibody Complex↗
PubMed1977

Passive transfer of autoimmune disease with isologous IgG1 and IgG2 antibodies to the tubular basement membrane in strain XIII guinea pigs: loss of self-tolerance induced by autoantibodies.

Initiation of an autoimmune tubulointerstitial disease was achieved in strain XIII guinea pigs by passive transfer of functionally pure IgG1 or IgG2 fractions of isologous anti-tubular basement membrane (TBM) serum. IgG2 appeared to be somewhat more effective than IgG1. The immunopathologic features in the IgG1 and IgG2 recipients were similar at the time of sacrifice, 14 days after transfer. The recipients that developed disease had higher than expected anti-TBM titers at 14 days. Furthermore, anti-TBM antibodies were of both IgG isotypes. In contrast, simultaneously administered IgG1 or IgG2 anti-BGG antibodies declined in titer in the recipients and were never found in the isotype fraction that had not been transferred. These findings indicate that the recipients of anti-TBM antibodies of either IgG1 or IgG2 isotype were stimulated to produce anti-TBM autoantibodies, which participated in the pathogenesis of the renal disease. The model demonstrates that autoantibodies may provide a mechanism (autoimmune amplification) for the intensification and perpetuation of antibody-mediated autoimmune diseases.

Animals↗
PubMed1977

Binding of soluble immune complexes in serum of patients with Hodgkin's disease to tissue cultures derived from the tumor.

We examined 90 serums from patients with Hodgkin's disease for immune complexes and for reactivity with established monolayer tissue cultures prepared from the tumor. All 23 serums with immune complex levels greater than 20 microgram per milliliter were found to react with cultured cells of patients with Hodgkin's disease when tested with antiserums against immunoglobulin heavy and light chains and the C3 component of complement. Five of 11 serums with borderline elevations of immune complexes (10 to 20 microgram per milliliter) and only four of 56 with levels less than 10 microgram per milliliter reacted. Absorption of patients' serums with cultured cells removed immune complexes and eliminated binding to monolayers. Immune-complex-containing serums from 19 control patients did react with cultured cells of patients with Hodgkin's disease; none of serums reacted with normal cultured spleen. Antibodies within complement-containing immune complexes in serums of patients with Hodgkin's disease react with an antigen on the surface of cultured cells of such patients.

Animals↗
PubMed1976

Psychiatrist-wife-mother: some aspects of role integration.

Throughout her professional life the woman who chooses to combine the roles of psychiatrist, wife, and mother may find them not only compatible but complementary. If she can adopt a philosophy of life that permits her to function in these roles, and if those around her support her activities, she can perform with relative ease and proficiency. Her lifestyle must of necessity differ from that of her male colleagues, but differing lifestyles among members of a profession vitalize the field. A broad perspective is desirable, especially in a profession that deals with the emotional and mental lives of people. Married women and mothers afford such a broadened perspective to the field of psychiatry.

Family↗