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Biomedical subjects

K C Suen

Publications and source records attributed to K C Suen.

26 records · Page 2Linked to original sources
PubMed1978

Role of imprint cytology in intraoperative diagnosis: value and limitations.

Imprints prepared from fresh surgical specimens give excellent cytological clarity. Used intraoperatively, the imprint method can provide valuable information when frozen-section interpretation is equivocal. However, cytologically well-differentiated tumours and tumours with a dense fibrous stroma, constituting 6% of the cases in the present series, cannot be diagnosed by this method. To increase diagnostic accuracy we recommend the combined use of imprints and frozen sections. The imprint technique requires little additional work and does not delay the frozen-section procedure.

Cytodiagnosis↗
PubMed1976

The use of imprint technic for rapid diagnosis in postmortem examinations. A diagnostically rewarding procedure.

An imprint method used as a means to provide rapid diagnosis at the time of postmortem examination is described. Although this method is not new, it has hitherto received relatively little attention in this country. The method is simple and as reliable as the frozen-section method, yet less time-consuming. Experience has shown that this technic can be employed in the diagnosis of cancer as well as nonneoplastic diseases. It is the intent of this communication to emphasize the usefulness of the technic and its wide application in postmoretn material. Smears so prepared can be readily interpreted by the general pathologist.

Adult↗
PubMed1975

Endocrine-type granules in cells of glomus tumor of the stomach.

The ultrastructure of a gastric glomus tumor was studied. The tumor cells were found to possess structural features similar to those of smooth muscle cells. In addition, hitherto undescribed granules of endocrine type and cilia were identified.

Basement Membrane↗
PubMedDate not supplied

Diagnosis of primary hepatic neoplasms by fine-needle aspiration cytology.

This article describes the cytologic features of various primary hepatic neoplasms as seen in fine-needle aspirates. Hepatocellular carcinoma can be differentiated from metastatic carcinoma by its tendency to recapitulate the characteristics of normal hepatocytes, namely, resemblance of the neoplastic cells to liver cells, growth in trabeculae, and bile production. Fibrolamellar hepatocellular carcinoma is characterized by larger, polygonal tumor cells with clearly defined cell outline, deeply eosinophilic granular cytoplasm, and extremely large solitary nucleoli. Lamellae of fibrocytes are seen dividing the tumor cells into small groups. Hepatocellular adenoma and focal nodular hyperplasia exhibit cells that are benign-appearing or minimally atypical. Cholangiocarcinoma is an adenocarcinoma and cannot be differentiated from metastatic adenocarcinoma on purely morphologic grounds. Primary hepatic sarcoma is exceptionally rare and shows malignant spindle cells. Some inflammatory conditions such as abscess, cysts, and tuberculoma often present as space-occupying lesions and should be included in the differential diagnosis of hepatic neoplasm.

Adenoma, Bile Duct↗
PubMedDate not supplied

Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma.

The major cytologic features seen in fine needle aspirates from two cases of fibrolamellar hepatocellular carcinoma were: liver-like tumor cells, characterized by plump, polygonal forms with eosinophilic, granular cytoplasm; large oval nuclei with extremely prominent solitary nucleoli; and parallel bands of fibrous tissue and fibrocytes seen within the tumor fragments. Other helpful features included intracytoplasmic hyaline globules and well-delineated pale bodies. Clinically, the tumors occurred in young patients with noncirrhotic livers and ran a more favorable course than do other types of hepatocellular carcinoma.

Biopsy, Needle↗
PubMedDate not supplied

A comprehensive internal quality control system for a large cytology laboratory.

The British Columbia Cervical Cytology Program is operated through the Central Laboratory at the Cancer Control Agency in Vancouver and processes all of the gynecologic Papanicolaou smears collected by 3,200 physicians throughout the province of British Columbia. The laboratory receives approximately 2,400 smears per day, and the program currently processes in excess of 500,000 smears annually. This article describes the methods that have been developed for ensuring that adequate quality control is present in the screening and interpretation of half a million smears per year, both at the cytotechnologist and at the cytopathologist level. The results of the quality control program, which was considerably modified in 1985, are also presented. The modified program shows a significant improvement in the number of undercalled and overcalled cases detected in two comparable six-month periods.

British Columbia↗
PubMedDate not supplied

Some cytologic features of hepatocellular carcinoma as seen in fine needle aspirates.

Cytologic study of fine needle aspirates in 15 cases of hepatocellular carcinoma revealed the following cellular patterns in order of decreasing frequency: trabecular, acinar and anaplastic. The most useful cytologic criteria for the identification of hepatocellular carcinoma were the similarity of tumor cells to liver cells, the prominence of nucleoli and the frequent presence of a trabecular pattern. Our study showed that the cellular changes seen in aspirated material faithfully reflect the histologic alterations seen in tissue sections. Hence, familiarity with the histology of hepatocellular carcinoma is of tremendous value in the interpretation of cytologic material.

Adenocarcinoma↗