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Biomedical subjects

K C Lam

Publications and source records attributed to K C Lam.

65 records · Page 4Linked to original sources
PubMed1978

Isoprinosine in classical acute viral hepatitis.

A prospective double-blind controlled study was performed on the effects of isoprinosine in 81 patients with clinical and histological features of classical acute viral hepatitis. Appetite was assessed daily. Serum alanine aminotransferase, aspartic aminotransferase, and bilirubin levels were assessed weekly. Changes in biochemical parameters, number of deaths, number of patients showing rise of aminotransferase levels despite treatment, and duration required for appetite to return to normal in each group were compared. Observation was continued for 4 weeks. Contrary to preliminary reports, no therapeutic benefit was demonstrated in any of these parameters. We concluded that isoprinosine was ineffective in the acute phase of classical acute viral hepatitis.

Alanine Transaminase↗
PubMedDate not supplied

Prednisolone in HBsAg-positive chronic active hepatitis: histologic evaluation in a controlled prospective study.

To study the value of corticosteroids in HBsAg-positive chronic active hepatitis, 18 pairs of liver histology comprising 36 liver biopsies from a prospective, randomized, controlled trial were evaluated. The median interval between the initial and follow-up histology was 8 1/2 months in 8 patients given prednisolone and 8 1/4 months in 10 patients given placebo tablets. Following medication, there was significantly greater erosion of the limiting plate in the prednisolone group (p = 0.039) accompanied by a larger quantity of HBsAg (p = 0.045) and HBcAg (p = 0.006) in the liver. We conclude that prednisolone causes immunosuppression permitting enhanced viral multiplication and leads to increased erosion of the limiting plate. Our result also indicates that progression to cirrhosis is unhalted by prednisolone therapy. The histologic findings support clinico-biochemical conclusion that the use of prednisolone is deleterious to patients with HBsAg-positive chronic active hepatitis.

Biopsy↗
PubMedDate not supplied

[Treatment of duodenal ulcers with antacid mixtures and sulpiride. A double-blind controlled study (author's transl)].

A total of 108 patients with duodenal ulcers were divided into 4 groups in a double-blind study controlled by endoscopic examinations. Patients in each group were given either an antacid mixture or sulpiride alone, antacid mixture plus sulpiride, or a placebo. The highest complete recovery rate (84 per cent) was noted in the antacid mixture plus sulpiride group, while partial healing (more than 50 per cent reduction in ulcer size) was highest in the sulpiride group (84,6 per cent). As sulpiride has both healing effects on the ulcer and an analgesic effect against pain it can be prescribed in association with antacid mixtures for the treatment of duodenal ulcers.

Antacids↗