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Biomedical subjects

K Bruce

Publications and source records attributed to K Bruce.

5 recordsLinked to original sources
PubMed1985

Rehabilitation of the disabled adolescent: experience with a local authority assessment centre.

School leavers and young adults who are severely physically disabled pose particular problems for habilitation and rehabilitation. A local authority unit, the Fourways Assessment Centre, has been providing a comprehensive service to this group of people for the past 10 years. Rather than operating as an independent self contained unit it has been closely integrated with the local authority social services and educational services.

Adolescent↗
PubMed1981

A computer program for distinctive feature analysis.

A computer program is described that will accomplish a distinctive feature analysis for speech misarticulations. The program, which is written in FORTRAN, is interactive in nature and is straightforward in design. It greatly facilitates the use of distinctive feature analysis in articulation training, as it reduces the time necessary to complete such an analysis from several hours to approximately 15 min.

Diagnosis, Computer-Assisted↗
PubMedDate not supplied

Notes on a light and electron microscopic double-labeling method combining anterograde tracing with Phaseolus vulgaris leucoagglutinin and retrograde tracing with cholera toxin subunit B.

Investigations of monosynaptic connections in the central nervous system have been hindered by the lack of compatible markers that can be used at both light and electron microscopic levels. In attempts to determine synaptic contacts between fibers originating in the substantia nigra and neurons projecting to the spinal cord, we have developed a double immunolabeling technique using anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L) and retrograde transport of unconjugated cholera toxin subunit B (CTB). In this report, we describe technical modifications which consistently produced superior labeling together with adequate ultrastructural preservation of the tissue and discuss the advantages of the two tracers.

Animals↗
PubMedDate not supplied

Quantitation of medullary astrogliosis in sudden infant death syndrome.

One of the few relatively consistent pathologic observations in sudden infant death syndrome (SIDS) is astrogliosis of the brain stem. Astrogliosis is a nonspecific reactive process and its cause in SIDS, although still uncertain, is postulated to be hypoxia-ischemia. In this study, the distribution of reactive astrocytes throughout the rostral-caudal extent of the medulla has been determined. Although astrogliosis was present throughout the length of the medulla, it reached a maximum at levels 50-75% of total length, with 0% at the pontomedullary junction. Counting every reactive astrocyte through serial sections of the medulla seems unwarranted in view of the nonspecificity of the astrocytic response. This report proposes a practical approach to the quantitation of reactive astrocytes in SIDS by examining a representative sample of medulla midway through its length.

Astrocytes↗