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Biomedical subjects

K Brown

Publications and source records attributed to K Brown.

At least 487 records · Page 27Linked to original sources
PubMed1976

Role of the hypophysis in estrogen-mediated induction of enzymes in the regenerating liver from castrated male rats.

Perfusions with corticosterone, of isolated regenerated livers from adult male rats, subjected to castration, partial hepatectomy and hypophysectomy with or without estradiol treatment during parenchymal regeneration, yielded very similar patterns of biliary steroid metabolites. The degree of steroid conjugation was lower than that seen in livers from normal, untreated, adult male rats. In operated animals, with or without estradiol benzoate treatment, ring A-reduced 20-keto metabolites constituted about 20%, whereas metabolites with a 20-hydroxy group made up approximately 80% of the corticosterone metabolites formed. Furthermore, no 15-hydroxylated metabolites derived from corticosterone, quantitatively the most important compounds in bile from female rats, could be detected in bile from these treated male animals. However, livers from male rats which had been castrated, hepatectomized and treated with estradiol benzoate during liver regeneration, produced 15-hydroxy-tetrahydrocorticosterone to the same extent as female rat livers, when perfused with corticosterone. The results obtained indicate that the effects of estradiol on the induction and differentiation of steroid metabolizing enzymes in the regenerating liver are pronounced and manifested only in the presence of an intact hypophysis.

Animals↗
PubMed1976

Levels of C-type viral p30 antigens in lymphoma-resistant mice.

Until relatively recently, interest has largely centered upon the causal role of oncogenic viruses especially with respect to the development of murine lymphomas. Host factors have recently come to the fore and are considered to be effective here, where we note that, in spite of relatively high levels of C-type viral antigen in the AKR X CBA F1 mouse, this hybrid remains relatively lymphoma resistant. Evidence points to an overriding host factor in this situation that is dominant with respect to tumor resistance and furthermore independent of the viral load at least as judged by levels of p30 viral antigen, an assumption confirmed by xc plaque assay.

Animals↗
PubMed1975

The lack of association of theta status and murine leukaemia virus content in the AKR.

Two AKR sublines appear atypical in possessing theta C3H. One of these two sublines - AKR/FuA - is notably resistant to lymphomata and is also characterized by reduced levels of the group specific murine leukaemia viral (MuLV) antigen. This suggested a possible association between theta status tumour susceptibility and viral content. Results here show no reduction in viral antigen titres in the other theta C3H tumour susceptible subline AKR/Cum, thus eliminating the possible association of theta status with the extent of MuLV replication.

Animals↗