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Biomedical subjects

K Brady

Publications and source records attributed to K Brady.

At least 91 records · Page 5Linked to original sources
PubMed1989

Atracurium, vecuronium, and pancuronium do not alter the minimum alveolar concentration of halothane in humans.

The authors studied 64 unpremedicated, healthy surgical patients, aged 42 +/- 14 yr, to determine the effects of atracurium, vecuronium, and pancuronium on the minimum alveolar concentration (MAC) of halothane. Anesthesia was induced using halothane/nitrous oxide/oxygen via a mask without the administration of other drugs. Nitrous oxide was discontinued, the trachea was intubated without prior administration of neuromuscular blocking drugs, and anesthesia was maintained with halothane in oxygen. Participating patients were assigned to one of five groups: 1) no neuromuscular blocking drug (control group, n = 9); 2) atracurium 0.5 mg/kg (n = 10); 3) atracurium 1.0 mg/kg (n = 15); 4) vecuronium 0.1 mg/kg (n = 20); or, 5) pancuronium 0.1 mg/kg (n = 10). Tourniquets, inflated to 300 mmHg immediately before iv administration of neuromuscular blocking drug and 15-30 min prior to skin incision, were used to isolate extremities from circulating neuromuscular blocking drug in all patients. A positive response to stimulation was defined as movement of at least one extremity occurring distal to the tourniquet within 1 min following skin incision. The first patients in the control and atracurium groups were studied at an end-tidal halothane concentration of 0.95%. The first patient in the pancuronium group was studied at a halothane concentration of 0.75%, and the first patient in the vecuronium group at 0.70%. Subsequent patients were studied at end-tidal halothane concentrations 0.10% above or below that of the preceding patient, depending on the presence or absence of movement with skin incision. Control MAC for halothane was 0.74% +/- 0.09% (mean +/- SEM).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Hydrops fetalis and premature closure of the ductus arteriosus: a review.

The purpose of this report is to describe a case of nonimmune hydrops fetalis that resulted from an unusual congenital heart defect, premature closure of the ductus arteriosus. In this fetus, the ductal closure was not associated with other heart defects such as tetralogy of Fallot or truncus arteriosus, nor was it related to maternal use of nonsteroidal antiinflammatory agents. Despite adequate digitalization of the mother, the fetus died of congestive heart failure at 29 weeks of gestation. Autopsy confirmed stricture of the ductus in association with enlargement of the foramen ovale and marked dilation of the right atrium and main pulmonary artery.

Adult↗
PubMed1989

Reliability of fetal buttock blood sampling in assessing the acid-base balance of the breech fetus.

This prospective investigation was undertaken to compare fetal buttock capillary blood pH and umbilical artery and vein pH in fetuses presenting by the breech. The study group comprised ten term patients with singleton fetuses in the frank breech presentation who met established criteria for vaginal breech delivery. All patients had a normal labor pattern. Eight fetuses had a normal fetal heart rate tracing and two had severe variable decelerations during the second stage of labor. We obtained capillary blood for pH measurement from the fetal buttock within 15 minutes of delivery. Immediately after delivery, we collected arterial and venous blood samples from the umbilical cord for measurement of pH. In all fetuses, there was a highly significant correlation between fetal buttock capillary blood pH and umbilical artery pH (r = 0.96; P less than .001) and umbilical vein pH (r = 0.88; P less than .001). We conclude that measurement of pH in capillary blood obtained from the fetal buttock provides accurate assessment of the acid-base status of the breech fetus.

Blood Specimen Collection↗
PubMed1989

Cytologic characteristics of neoplastic and of regenerating hepatocytes in fine needle aspirates of rat liver.

L-azaserine (l-aza)-induced hepatocellular carcinoma (HCA) and hyperplastic liver lesions were studied in livers from 86 l-aza treated animals and 16 saline controls. Eight additional rats studied 24 or 48 hr after partial hepatectomy and 8 young rats studied after no experimental manipulation served as additional controls for determination of cytologic effects of increased cell turnover. Fine needle aspirates (FNA) were made of all gross liver lesions and of grossly normal liver; H&E stained sections of liver surrounding each needle track were made. The FNA were fixed in 95% ethanol, stained with a routine Papanicolaou stain, randomized, and evaluated using 18 cytologic features. They were diagnosed without knowledge of the histologic diagnosis or treatment group. Features were analyzed with discriminant function analysis to determine their relative importance in making the diagnosis. FNA proved to be an accurate method for diagnosis of hepatocellular lesions in laboratory animals. The cytologic features of greatest usefulness in establishing the diagnosis were cord pattern, chromatin pattern, nucleolar size and nuclear membrane irregularity. FNA could provide a useful experimental technique for following evolving lesions serially and for identifying subgroups within hyperplastic nodules.

Animals↗
PubMed1989

Reliability of a rapid latex fixation test for detecting group B streptococci in the genital tract of parturients at term.

The purpose of this prospective investigation was to determine the reliability of a rapid latex particle agglutination test in detecting group B streptococci in the lower genital tract of laboring women. Five hundred asymptomatic patients with intact membranes who were in labor at term underwent sterile speculum examination. Secretions from the endocervix and vagina were collected with sterile swabs. One swab was inoculated directly onto a blood agar plate for culture. The other was initially placed into a Culturette transport system and then transferred into a test tube containing an enzyme extraction reagent. After a 60-minute incubation at 37C, the latex fixation test was performed on the residual liquid in the tube. The frequency of positive cultures in our population was 5.0%. The sensitivity and specificity of the rapid slide test were 88 and 99.6%, respectively. The positive and negative predictive values were 91.7 and 99.4%, respectively. The group B streptococci latex fixation test appears to be a rapid and reliable means of detecting group B streptococci in the lower genital tract of term patients with intact membranes. Use of this method should permit a more selective approach to the intrapartum chemoprophylaxis of women colonized with group B streptococci.

Female↗
PubMed1989

The effect of bacteriostatic lubricant on group B streptococcal cultures of the female genital tract.

The purpose of this prospective investigation was to determine the effect of bacteriostatic lubricant on group B streptococcal cultures obtained from the lower genital tract of pregnant women. Fifty pregnant women with intact membranes who recently had genital tract cultures for group B streptococci were evaluated. The study group consisted of 25 women who had positive cultures, and the control group comprised 25 women who had negative cultures. All patients underwent examination with a sterile nonlubricated speculum within 7 days of the previously obtained cultures. Secretions from the endocervix and from the posterior vaginal wall near the introitus were collected with a sterile cotton-tipped applicator and inoculated directly onto a selective blood agar culture plate. The sterile speculum was removed and a digital examination performed using bacteriostatic lubricant. A second sterile speculum was then inserted into the vagina and another group B streptococcal culture was obtained. There was 100% correlation between the cultures obtained before and after the vaginal examination. We conclude that use of bacteriostatic lubricant does not alter the recovery of group B streptococci from the genital tract of pregnant women with intact membranes.

Chlorhexidine↗
PubMed1988

The pathology of intrauterine thyrotoxicosis: two case reports.

The autopsy findings are described in two infants of hyperthyroid mothers in whom the clinical symptomatology, laboratory data, and autopsy findings strongly suggested intrauterine thyrotoxicosis secondary to transplacental thyroid-stimulating immunoglobulin. Documented intrauterine thyrotoxicosis is extremely rare, and we believe these to be the first detailed pathologic descriptions of the entity. Autopsy findings included slim habitus, massive thyromegaly, hypertrophic cardiomegaly, congestive visceromegaly, pulmonary hypertension, adenopathy, and prominent amniotic fluid aspiration. Both cases illustrate the positive contribution that a carefully performed autopsy, even in the severely macerated stillborn, can make toward better understanding of intrauterine disease.

Adult↗
PubMed1987

Ovarian myxoma.

The clinical history, light microscopic, electron microscopic, and immunopathologic findings of an ovarian myxoma in a 32-year-old woman are described. We believe this to be only the fourth such case reported.

Adult↗
PubMed1986

Metoclopramide.

Explore the source record for details and available documents.

Humans↗
PubMed1986

Training in geropsychology at the doctoral level: 1984.

To study type and amount of training in geropsychology available to students in APA-approved doctoral programs in clinical and counseling psychology, a questionnaire was mailed to all such programs in 1984. Response rate was 71 of 132 (59%) for clinical programs and 27 of 37 (73%) for counseling programs. Very little difference was found between responses of clinical and counseling programs and between this 1984 survey and one conducted in 1975-76. There seems to be a very small increase in training opportunities for psychology students in geropsychology in 1984 at the doctoral level.

Education, Graduate↗
PubMed1986

Effects of an observer on conformity to handwashing norm.

Women were observed after elimination in a public restroom to determine the effects of the presence or absence of an observer upon the likelihood of handwashing. 18 of 20 subjects in the presence of another and 3 of 19 who were not observed washed. The difference in frequency of handwashing between the two groups was clearly significant.

Female↗
PubMed1981

Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line.

The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limited and is saturated at concentrations of MNNG which do not saturate the systems removing 3-methyladenine. Pretreatment of cells with MNNG inhibits their ability to remove O6MeG produced by a subsequent dose given after 2 h. Treatment with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) is effective in diminishing cellular capacity for O6MeG removal, and cells unable to remove O6MeG and sensitive to the cytotoxic effects of MNNG are also more sensitive to ENNG than their removal competent counterparts. Regeneration of the ability to remove O6MeG requires incubation of cells for periods greater than 24 h. The O6MeG removal system is similar to that found in adapted Escherichia coli although the capacity of the Raji lymphoma line much lower than that of the induced bacteria per unit of DNA.

Burkitt Lymphoma↗