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Biomedical subjects

K Bork

Publications and source records attributed to K Bork.

At least 55 records · Page 3Linked to original sources
PubMed1988

Increasing incidence of eczema herpeticum: analysis of seventy-five cases.

Clinicians at the Department of Dermatology at the University of Mainz saw 63 patients with 75 episodes of eczema herpeticum. An analysis of these cases shows an exceedingly high rate of increased incidence of the disease. From 1969 through 1981, 13 cases were registered, whereas in the years 1982 to 1986 the number of cases was 62. The mean age of the patients was 22.7 years, and 42 patients (56%) were between 15 and 24 years of age. This finding shows that the affected patients are not predominantly infants, as has been reported up to now. Of these patients 5 had one recurrence, two had two recurrences, and one had three recurrences. Acyclovir, used for treatment in 38 cases, led to rapid improvement, whereas therapy with immunoglobulins, antibiotics, and so-called immunostimulating agents did not clearly influence disease duration.

Acyclovir↗
PubMed1988

[Flagellar motility amd movement of boar spermatozoa during epididymal transit].

The motility of boar spermatozoa during epididymal transit was analysed in vitro using various techniques. From the head to the cauda there was an increase of the percentage of motile and progressive spermatozoa. During maturation there was a progressive reduction of flagellar bend curvature while flagellar beat frequencies increased. A three dimensional pattern of flagellar beating responsible for cell rotation and straight line progression of spermatozoa was observed only in caudal epididymis. The addition of epididymal fluid protein to the media could increase the number of motile cells at the various levels but had no influence on the characteristics of flagellar bending.

Animals↗
PubMed1988

[Prurigo and further diagnostically significant skin symptoms in strongyloidosis].

An increasing incidence of strongyloidosis must be expected in European countries as a result of the increasing numbers of immigrants, as well as holiday-makers returning from tropical regions. In addition to gastrointestinal symptoms, dermatological complaints are predominant. Only rarely are cutaneous symptoms the only clinical manifestation of disease. The penetration of filariform larvae may cause "ground itch." In cases of chronic disease, larva currens is the most obvious sign and consists of linear urticarial wheals evoked by larva migration. The most common non-specific symptoms are rashes, pruritus and urticaria. A further symptom of strongyloidosis, intensely itching prurigo, is described in a 20-year-old female Thai. Remission was achieved following tiabendazole therapy.

Adult↗
PubMed1988

Hereditary progressive mucinous histiocytosis in women. Report of three members in a family.

We describe three female patients in a family of two generations, who suffered from generalized and maximally pea-sized histiocytic tumors beginning in early adolescence. The disease ran a uniform and slowly progressive course and was confined to the skin. There were no signs of spontaneous tumor regression. Histologic, immunohistochemical, and ultrastructural examination revealed the histiocytic nature of the tumors. An outstanding finding was a marked production of mucinous material, predominantly in long-standing tumors. This nonlangerhansian syndrome differs from other benign normolipemic histiocytic diseases with generalized histiocytic tumors by inheritance, which is most likely autosomal dominant, and by other clinical and histologic features. Since a storage disease could be excluded, the syndrome presented here seems to be a hitherto unknown entity among the benign generalized histiocytoses.

Adult↗
PubMed1987

[Differential diagnosis and therapy of recurrent aphthae].

The differential diagnosis of aphthous stomatitis includes several viral diseases, such as gingivostomatitis herpetica, recurrent intraoral herpes simplex, herpangina, hand-, foot-and mouth disease, as well as drug eruptions, traumatic ulcers, and aphthoid lesions in neutropenia. The therapy of aphthous stomatitis is designed to control pain, shorten the course of present lesions, and prevent the development of new lesions.

Diagnosis, Differential↗
PubMed1987

Autoantibody-mediated acquired deficiency of C1 inhibitor.

During the past 25 years, three forms of deficiency of the inhibitor of the first component of complement (C1 inhibitor) with angioedema have been recognized; two forms are hereditary and one is acquired. As compared with hereditary angioedema, the syndrome of acquired C1-inhibitor deficiency is rare, and it is usually associated with lymphoproliferative diseases. We report another type of acquired C1-inhibitor deficiency with angioedema. Two patients with recurrent angioedema but no associated diseases were found to have IgG1 autoantibodies against C1 inhibitor. The anti-C1-inhibitor antibodies prevented binding of C1 inhibitor to activated C1s. Both patients had 60 to 70 percent of normal levels of C1 inhibitor, but it was functionally inactive, with a molecular weight of 96,000 (normal C1 inhibitor, 105,000). In vitro studies of the patients' serum revealed degradation of 125I-labeled 105,000-dalton C1 inhibitor into the inactive 96,000-dalton molecule, caused by activated C1s and not found in normal human serum. We conclude that these cases of acquired C1-inhibitor deficiency resulted from a blockade of C1-inhibitor function by the anti-C1-inhibitor antibodies and from subsequent inactivation of C1 inhibitor by the now uncontrolled enzyme, activated C1s. As in other forms of C1-inhibitor deficiency, the unopposed activation of the complement system led to angioedema.

Adult↗
PubMed1987

[Formation of IgG antibodies to C1 inhibitor as the cause of life-threatening angioedema].

A clinical picture with recurrent (in some cases potentially fatal) edema of skin and internal organs based not on a hereditary C1 inhibitor deficiency, but an acquired loss of C1 inhibitor activity due to antibodies is described for the first time in two patients. The clinical symptoms commenced in middle age patients between 40 and 46 years old. Anti C1 antibodies of the IgG were found in both patients. Quantitatively, these C1 inhibitor protein was in the lower range of normal, whereas no inhibitor activity could be demonstrated functionally. The function of the complement components C1, C2 and C4 was greatly reduced. The therapeutic use of C1 inhibitor concentrate at a high doses (6 X 500 U) as well as administration of high-dose corticosteroids in several emergency situations was unsuccessful.

Adult↗
PubMed1987

[Contraception and pregnancy in hereditary angioedema].

The frequent first clinical manifestation of hereditary angioedema (HAE) in pubertal patients and the more frequent attacks of edema during menstruation indicate that the condition is affected by hormones. Medication with oral contraceptives containing estrogens can lead to severe attacks of edema. On the other hand, HAE mostly shows a favorable development in pregnancy. Despite the substantial trauma of delivery, complications are rare. In view of the literature report of a death and our own observation of potentially dangerous edema in the postpartal phase in one patient, it appears to us to be advisable to administer 500 units C1 inactivator prophylactically before the expulsive phase of birth in HAE patients. Oral contraceptives should not be administered.

Adult↗
PubMed1987

Impaired function of numerically augmented Fc-receptors on granulocytes in a HLA B8+ patient with palmoplantar pustulosis.

We examined granulocytes or polymorphonuclear leukocytes (PMN) in an HLA B8+ patient with palmoplantar pustulosis (PPP). Controls included another patient with PPP, however, lacking this antigen and a healthy, HLA B8+ person. Chemiluminescence (CL) served to monitor the respiratory burst in PMN comparing as stimuli zymosan, opsonized zymosan, phorbol myristate acetate, as well as aggregated immunoglobulin (aggIg), the latter as Fc-receptor (FcR) stimulus. FcR density on PMN was determined using 125I-IgG and expressed in the form of Scatchard plots. The effects of serum on the aggIg-induced CL were also measured. We found both control individuals to respond to stimulation by aggIg as a function of a dose-dependent increase of CL. By contrast, the HLA B8+ patient with PPP failed to respond to aggIg; only the highest concentration of aggIg induced marginal CL. Conversely, stimulation by the other agents was similar in all three individuals. The patient with the functional FcR defect expressed 2.5 times more FcR/PMN than the controls. No difference emerged in comparing autologous serum with a reference normal serum on the aggIg-induced CL, ruling out saturation by serum factors alone to be a cause for the defect. In remission, the functional FcR was absent. Our results suggest a defect of signal transduction in PMN from numerically enhanced FcR to the cytosol in the patient with PPP.

Adult↗
PubMed1987

[Psoriasis and bullous pemphigoid].

The coexistence of psoriasis and bullous pemphigoid in 44 patients has been described in the literature. In the majority of cases no causative agent was found for the development of bullous pemphigoid, but in many cases the bullous eruption was related to antipsoriatic treatment such as PUVA, anthralin, tar and salicylic acid. A 46-year-old man with a 20-year history of psoriasis who developed bullous pemphigoid without any previous therapy is described. After clearing, a later exacerbation of both psoriasis and bullous pemphigoid indicated that there is a pathogenetic relationship between the diseases. Among 72 patients with bullous pemphigoid no others suffered from psoriasis.

Autoantibodies↗
PubMed1987

[Flea bites caused by Archaeopsylla erinacei, the hedgehog flea].

A hedgehog flea was the cause of multiple flea bites in a 48-year-old patient. The main host of the hedgehog flea is the European hedgehog, but the flea was also found in different furry mammals, such as polecats, brown rats and foxes. It was not previously known that Archaeopsylla erinacei attacks man.

Animals↗
PubMed1987

[Multiple simultaneous hematomas of the finger and toe nails with subsequent onychomadesis in pemphigus vulgaris].

Multiple simultaneous subungual and intraungual haemorrhages were seen in eight fingernails and several toenails of a patient suffering from pemphigus vulgaris. As other causes of nail haematomas, such as traumas, were absent, this symptom was referred to the underlying disease. Nail and nailbed involvement in pemphigus vulgaris is extremely rare, and onychomadesis is the form that has been reported more frequently than any others.

Hematoma↗
PubMed1986

[Contact dermatitis caused by PVP-iodine].

Allergic contact dermatitis to PVP iodine is rare. Such an occurrence in a 81-year-old woman is reported. Extensive blistering dermatitis developed after local application of a PVP iodine solution. As in all previously described cases of allergic contact dermatitis from PVP iodine, it was a reaction not to the PVP but the free iodine. More important than contact reactions are hyperthyroidism or thyrotoxic crises due to percutaneous or transmucous absorption of iodine or iodide in susceptible persons.

Aged↗
PubMed1986

Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis.

Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clinically uninvolved skin in psoriasis (autologous mixed epidermal cell lymphocyte reaction, AMECLR). Age- and sex-matched individuals served as controls. We found that the AMLR in psoriasis (n = 11) was similar to that in healthy controls (n = 16); furthermore, cell proliferation was alike in the presence of either 5% AB-serum or autologous serum. By contrast, while the AMECLR in healthy controls (n = 9) resembled that in psoriatics employing epidermal cells from univolved skin, epidermal cells from lesional sites (n = 10) induced a significantly higher proliferation of autologous T cells in the AMECLR (P less than 0.01). We conclude that the in vitro stimulation of T cells by non-T mononuclear leukocytes is normal in psoriasis and is not regulated by autologous serum. Lesional psoriatic epidermal cells, however, are more active in stimulating autologous T cell proliferation than cells from univolved psoriatic or normal epidermis.

Adult↗
PubMed1986

Immunological detection of actin in isolated cilia from quail oviduct.

Cilia from quail oviduct were isolated with their membrane. The ultrastructural study revealed a good preservation of cilia in the purified fraction. Electrophoresis on SDS-PAGE showed a reproducible pattern of ciliary proteins, the major bands being those of tubulins 57 kDa and dyneins above 250 kDa. Among the minor bands, an immunological study was focused on a 43 kDa molecular mass protein, using monospecific antibodies against actin. Presence of actin was then detected by immunoblotting of isolated cilia fractions as well as of demembranated cilia, suggesting that actin is associated with the axoneme. The presence of actin in the cilia was confirmed by immunofluorescence. The cilia were found stained only on the proximal part, suggesting an heterogeneous distribution of actin within the axonemal length.

Actins↗