Observations of fetal breathing movements transmitted through maternal abdominal wall.
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Biomedical subjects
Publications and source records attributed to K Boddy.
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Total body potassium was studied in 33 patients with chronic renal failure, 18 of whom had been receiving regular dialysis therapy for 1 to 48 months. In nondialysed patients body potassium was not significantly different from normal in the group as a whole, but was significantly greater than normal in three patients, and significantly less than normal in two patients. In 14 of the dialysed patients, both as individuals and as a group, body potassium was not significantly different from normal but in the remaining four it was less than normal.Potassium transfer during dialysis was studied in two patients. Uptake by these two patients of (43)K added to the dialysate (1 mEq K/litre) was measured by whole-body monitoring. Transfer of administered (43)K from the patients to the dialysate was measured by whole-body monitoring and by radioactive and chemical assay of the dialysate. A negative balance due to twice-weekly dialysis of 178 and 244 mEq K/week was found, which with weekly faecal and urine losses of 20-30 mEq K approximately equals the dietary intake of 210-315 mEq K.
Total body potassium determined by whole-body monitoring and exchangeable body potassium estimated with (43)K were measured simultaneously in 12 patients with stable chronic renal failure. Values for the exchangeable potassium were obtained after equilibration periods of 24, 48, and 64 hours. The exchangeable body potassium, expressed as a percentage of the total body potassium (mean +/- S.E. of mean), gave values of 60.7 +/- 3.3%, 83.6 +/- 2.7%, and 85.9 +/- 2.7% at 24, 48, and 64 hours respectively. It seems that the equilibration between radioactive and native potassium is incomplete after 24 hours; and that exchangeable potassium measured at this time is not an accurate index of the status of total body potassium in such patients. Furthermore, the finding that the value at 64 hours is significantly less than found in healthy subjects suggests that the exchangeable potassium is a smaller fraction of the total body potassium in patients with chronic renal failure.
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Total body potassium was measured in 103 healthy adults using a shadow-shield whole-body monitor of high sensitivity. The range of height was 147 to 192 cm, of weight 43 to 92 kg, and of age 18 to 77 years. The values obtained for total body potassium were correlated with height, with weight, and with height and weight. Age was then included as an additional variable. The standard deviation from regression was smaller when total body potassium was correlated with height than with weight and was further reduced, to about 9%, in a multiple regression using height and age. The advantages of this relationship over indices involving weight are discussed. The smallest standard deviation from regression, 7.5%, was obtained when total body potassium was correlated with height, weight, and age. The usefulness of this relationship is discussed with comment on its limitations.A regression equation was derived between lean body mass (derived from height and weight) and total body potassium with a standard deviation from regression of 5.5% in males and 7.3% in females.
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An ultrasonic technique for detecting fetal breathing in utero has been developed using chronic fetal lamb preparations, and has been used successfully in pregnant women.
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