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Biomedical subjects

K Blomqvist

Publications and source records attributed to K Blomqvist.

36 records · Page 2Linked to original sources
PubMed1979

Immunologic features of chronic granulomatous mucocutaneous candidiasis before and after treatment with transfer factor.

We report the acquisition of skin test sensitivity to Candida albicans antigen and the ability to produce leukocyte migration inhibition factor (MIF) by a Candida-negative patient with chronic granulomatous mucocutaneous candidiasis after treatment with dialyzable transfer factor (TFd). The TFd was acquired from Candida-positive healthy donors. Three of seven attempts to transfer Candida skin test sensitivity were successful, and the acquired skin reactivity lasted for 12 to 21 days. The acquisition of cellular immunity to Candida was demonstrated in vitro by production of leukocyte MIF. No Candida-induced lymphocyte transformation was observed before or after TFd injection. The TFd did not cause Candida-induced blast transformation when added directly to cultures of lymphocytes from the patient. Pain, tenderness, redness, and edema were observed around the Candida granulomas on each occasion when the skin test to Candida became positive. Two weeks after TDd injection, the proliferative response of peripheral blood lymphocytes increased, as measured by incorporation of tritiated thymidine into lymphocytes within the first hour of in vitro incubation.

Candidiasis, Cutaneous↗
PubMed1978

Systemic miconazole treatment of a patient with chronic granulomatous mucocutaneous candidiasis.

Miconazole given intravenously and orally was evaluated in the treatment of a patient with drug-resistant, chronic, widespread horny candida lesions. Marked clinical improvement occurred after 4 weeks of the first course of treatment, in which 400 mg of miconazole per day was given intravenously. After 3 months no signs of the disease were apparent. The patient remained free of symptoms for 3 months, after which the lesions recurred and a second course of treatment, with 200 mg of miconazole per day intravenously, was started. A prompt clinical clearing was seen within 3 weeks, after which the miconazole (1 000 mg per day) was given orally. During oral administration of the drug a limited degree of recurrence of horny patches occurred. Systemic miconazole seems to be the drug of choice in the treatment of systemic chronic mucocutaneous candidiasis.

Administration, Oral↗
PubMed1977

Gluten-free diet in dermatitis herpetiformis. I. Clinical response of skin lesions in 81 patients.

Eighty-one patients with dermatitis herpetiformis were treated with a gluten-free diet (GFD) for periods varying from 6 to 36 months. At the end of the treatment the daily requirement of dapsone was significantly lower in patients treated with a GFD than in 49 patients on a normal diet. 93% of the patients on a GFD were able to reduce the dose of dapsone whereas only 16% of the patients on a normal diet were able to do this. Complete remissions occurred only in patients on a GFD. 28% of the patients on a GFD were able to stop dapsone completely and were continuously asymptomatic when they observed a strict diet. A response to a GFD was noted on the mean daily requirement of dapsone as soon as the treatment was initiated although the length of time for an individual response varied. After one year on a GFD the patients needed on average about 40% and after 3 years about 20% of the dose required to control skin symptoms at the beginning of the diet. The patients responded to a GFD irrespective of changes found in the jejunal mucosa and irrespective of the presence of absence of HLA-B8.

Adolescent↗
PubMed1975

Simultaneous application of pulsed high frequency currents and gamma-rays to cultured melanoma cells.

Cells differentiated from a human metastasizing melanoma have been irradiated simultaneously with pulsed high frequency currents (27.12 MHz, 400--600 pulses/s, pulse duration 65mus, average power 25--38 Watt) (Diapulse), and gamma radiation from a Co-60 source. Simultaneous pulsed high frequency field and gamma radiation acted in a way resembling a cell-protecting mechanism, enhancing the number of surviving cells to the extent of about 15 percent as compared with the cell number scored after pure Co-60 gamma-radiation treatment. Irradiation with pure high frequency currents resulted in increasing cell death for a period of up 4 minutes; subsequently, this seemed to be almost independent of time. The number of cells which survived, as compared with the controls, was found to be approximately 80 percent, near a distance of 6.5 cm from the symmetry axis, perpendicular to the plane of the radiating element.

Cell Survival↗