Search PubMed⌕ Search

Biomedical subjects

K Bilek

Publications and source records attributed to K Bilek.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Therapeutic vascular embolization in life-threatening gynecologic hemorrhages].

Report on 12 women with acute massive or chronic tumor hemorrhage, treated with embolisation. There were 7 women with cervical cancer T3/T4, 3 women with adenocarcinoma (2mal primary progressive, one with metastases in lymph-nodes), one woman with progressive malignant mesenchymale tumor in vagina and one with local persistent ovarian cancer. In 10/12 cases hemorrhage stopped immediately after embolisation. In 3 cases, after one-sided embolization, repeated procedure of the contralateral vessel was necessary. In 2/12 cases side-effects like fever and subileus, and, in one case, complications like skin necrosis and bladder-vagina-fistula were seen. In all patients temporary improvement of life-quality were found. Low risk and good tolerance of this palliative therapy are emphasized.

Adenocarcinoma↗
PubMed1984

[Transposition of the ovaries for function preservation in radical surgery and post-irradiation of cervical carcinoma].

It is recommended to leave behind the ovaries in their place in radical surgery of cervical cancer, if post-operative irradiation is not necessary. In cases of post-operative radiation therapy it is possible to preserve the function of the remaining ovaries by their transposition out of the irradiation area during operation. The operative technique for ovarian (adnexal) transposition will be demonstrated, and first informations about experiences and results are given. In 44 patients with cervical cancer from stage T1 b No Mo to T2 N1Mo a Wertheim-Meigs-operation with simultaneous ovarian transposition was performed, and 30 of them had a post-operative radiation therapy. In 44% of the radiation group was no change, in 24% a small restriction, and in 32% a total loss of ovarian function. The reasons of the unsuccessful lifting procedure are discussed, and possibilities for improvement of this management are shown.

Adult↗
PubMed1983

[Differential diagnosis of varicose hemorrhage in pregnancy].

The problem of differential diagnosis of varicose bleeding is referred by means of a case of recurrent profuse vaginal bleeding during the 7th month of pregnancy. The bleeding occurred after cerclage and because of a suspected placenta praevia we did a cesarean section. This was followed by hysterectomy because of persisting bleeding. A vesico-vaginal-fistula occurred in consequence of maneuvers to stop bleeding at vaginal cuff. After recognizing and abolishing the reason of the bleeding we observed a normal healing. The closure of the fistula was successful.

Adult↗
PubMed1982

[Histochemical examination of the endometrium following laparoscopic follicle puncture for the collection of ovocytes].

The ovarian follicles of six normocyclic women were laparoscopically punctured and aspirated on the eleventh or twelfth postmenstrual day of the cycle. Ovocytes and follicular fluid are characterised. Endometrial biopsies were taken of the patients concerned, after two days or so had been allowed to pass.--On histochemical evaluation, the abraded material seemed to exhibit early signs of beginning secretion as a "normal" endometrial response to artificial follicular rupture. The findings are discussed with reference to unanswered questions regarding in vitro fertilisation of human probands.

Endometrium↗
PubMed1982

Radical pelvic surgery versus radical surgery plus radiotherapy for stage Ib carcinoma of the cervix uteri. Preliminary results of a prospective randomized clinical study.

In a preliminary report of a prospective controlled study treatment results and therapy morbidity of 60 patients with stage pT1bNoMo carcinoma of the uterine cervix treated by radical surgery only (Wertheim-Meigs) were compared with those of 60 patients treated by radical surgery followed by a postoperative external radiotherapy. The median duration of follow-up was 44 (24--72) months. Comparing the survival probability analyzed by life-table-method up to 18 months there was a significant better result for patients treated with surgery only. However, after that the study demonstrated comparable therapeutic results with the two therapeutic regimens. There was no difference of tumor size in patients who died after surgery alone and those who died after combined therapy. The therapy morbidity was slightly greater in patients treated by combined therapy. Especially lymphedemas of the leg developed more frequent in patients treated with combined surgery and radiotherapy. Preliminary analysis of the study does not demonstrate any beneficial effect of postoperative radiotherapy followed a radical hysterectomy with pelvic lymphonodectomy in cervical cancer stage pT1bNoMo, but optimal staging, radical surgery and carefully histological examination of the removed tissue are essential needs for this approach.

Adult↗
PubMed1981

[Problems of radiotherapy in radically removed cervix cancers in stages T1b NO MO. Preliminary results of a randomized clinical trial].

A prospective controlled study was undertaken for the purpose of establishing the usefulness of postoperative radiotherapy following radical surgery of cervical carcinoma, Stage pT1b NO MO. A random selection was made of 120 patients who were either treated exclusively by radical surgery (Wertheim-Meigs) or in whom radical surgery was followed by postoperative telecobalt irradiation of the minor pelvis 50 to 52 Gy). No significantly difference were found to exist between the two therapeutic approaches, after an average period of follow-up observations of 33 months (between twelve and 60 months). The incidence of lymphoedema was increased with significance in those patients who had been irradiated.

Clinical Trials as Topic↗
PubMed1981

[Determination of radicality of iliacal lymphonodectomy in Wertheim's radical operation (author's transl)].

Lymphographic radicality may be determined by presurgical and postsurgical lymphography with measurement of radicality of iliacal lymphonodectomy. Lymphographically uncontrasted lymph nodes, as recordable from Wertheim's radical operation, accounted for 20 per cent in a surgical specimen. Radicality of lymph node counts can be calculated, for all practical purposes, by the following formula: RZ = Number of presurgical lymph nodes - posts, nodes.100 Number of presurgical lymph nodes Radicality, which can be calculated by surface and volume measurements of extirpated lymph nodes, is about 20 per cent in excess of the value obtained by counting. The latter approach was found to be suitable for research, in particular. Determination of radicality of lymphonodectomy is a practically useful aid in deciding post-surgical irradiation of patients who have undergone radical surgery for carcinoma of the cervix.

Female↗
PubMed1981

[Prematurity and placental insufficiency].

The authors analysed 1,528 "genuine" single premature births, between the 28th and 36th weeks of pregnancy and over a period between 1975 and 1979, with the view to establishing clinical manifestations of nutritive, respiratory, and hormonosynthetic disorders of the placenta as possible causes of prematurity. A high percentage of hypotrophic prematurely born infants (birth weights being 10. bis 5. and below 5. percentile) and even more latent nutritional deficiency in eutrophic prematurely born infants (average weight being below the 50th percentile in all weeks of pregnancy) seem to suggest the existence of a relationship between prematurity and nutritive placental insufficiency. Retardation of growth was found to aggravate along with growing age of gestation, but it was not found to result from previous tocolysis. Prematurely born infants are extremely endangered by reduced respiratory functionality of the placenta under the stress of birth, but this endangerment cannot be equally established before labour, with premature birth imminent.--Deficiently nourished foetuses are exposed to dangers of prepartum and intrapartum respiratory complications, even in cases of premature birth. These risk is likely to worsen along with aggravating impairment of nutritional functionality of the placenta. The effects of nutritional and respiratory placental insufficiency on acidosis morbidity, RDS incidence, and overall mortality (stillbirths and neonatal mortality included) of prematurely born infants are described and discussed. Biochemical hormone investigations have pointed in the direction of latent functional impairment of the placental or of foetoplacental unity in cases of prematurity at large. The morphological functionality of the placental villus trophoblast was found to be impaired in all cases so far reviewed, whatever the established clinical causes had been. This seems to be an important foundation for the concept of relationship between prematurity and placental insufficiency.

Acidosis↗
PubMed1978

[Clinical aspects of trophoblastic tumors].

Trophoblastic tumors are among the rare diseases in this country. The most important clinical aspects are demonstrated by references and personal experiences in the treatment of trophoblastic tumors. In many countries (SU, USA, GB, Japan) the treatment of trophoblastic tumors has been centralized.--The therapeutical strategy is based on histology, stage and other important prognostic factors. Most important is chemotherapy with antineoplastic substances. Surgery and radiation are to be used only under appropriate indication. After treatment the control of the HCG-values by radioimmunassay is of high importance for the early diagnosis of relapse.--All facts demonstrate, that also in the GDR a stronger centralization of the treatment of trophoblastic tumors should be attained.

Choriocarcinoma↗
PubMed1978

[Morphology and DNA content of cultures from normal and dysplastic epithelium, carcinoma in situ and carcinomas of the cervix uteri (author's transl)].

Morphology and DNA content were studied in explantate cultures of normal epithelium, persisting intraepithelial atypias (dysplasias and carcinomas in situ) and carcinomas of the cervix uteri. Intraepithelial atypias and carcinomas can be distinguished from the normal epithelium, growing strictly as a monolayer, chiefly by the primary and secondary loosening of the cellular lawn with increased tendency towards overlapping of cells. DNA determinations provide the possibility of demonstrating, also in vitro, deviations of the DNA content of dysplasias, carcinomas in situ and pavement epithelial carcinomas from the normal epithelium. The findings are in accord with the results which we obtained by in vivo studies and underlinions.

Biopsy↗
PubMed1978

[Histological-lymphographic findings in stage I A cervix cancer].

In 150 patients suffering from carcinoma cervicis uteri stage I A preoperative lymphographias and in 99 patients clinical and lymphographical follow-up controls were carried out. The histological proved metastases of the lymphonodes were less than 1%. Indications for preoperative lymphographias only are to be seen in carcinoma cervicis uteri stage I A2 for which histological criteria are presented.

Female↗
PubMed1978

[Relationships between the HPL determination in maternal serum and the condition of the associated placental villous trophoblast].

Relationships between the determination of human placental lactogen in materna serum and the condition of associated placental villous trophoblasts.--Taking as a starting point both qualitative and quantitative differences in the composition of placental villous trophoblasts subsequent to risk pregnancies, the proportions of different qualities of syncytium and average numbers of Langhans' cells per field of view in 24 placentas of neonates of the 37th to 41st weeks of pregnancy are compared with the corresponding maternal serum HPL (human placental lactogen) values. The significantly lower proportion of mature syncytium determined in the case of a low HPL value as well as the result of linear regression analysis are indicative of a dependence of maternal serum values for HPL upon the proportion of mature syncytium. This particular result is also interpreted by the authors as confirming the view that "mature" syncytium can be considered to be "functional" syncytium. Like other investigators, the present authors should also point out the importance of the total mass of placenta which can compensate for lower proportions of functional syncytium in individual resorption villi. Whereas there are clearly evident relationships between the maternal estriol values and the condition of placental villous trophoblasts, such relationships could not be observed in our material for oxytocinase and HSAP.

Alkaline Phosphatase↗
PubMed1977

[Studies on the recording of cytostatic effects on organ cultures of squamous cell carcinoma of the uterine cervix].

Organ cultures are a suitable in vitro test--object for pretherapeutical testing of cytostatic resistance on carcinomas of the cervix uteri. The decrease of activity of lactic dehydrogenase and isocitric acid dehydrogenase, determined histochemically, can be used to monitor cytostatic effects at the cultivated tumour. In preparing chemotherapy schedules for advanced cervical carcinomas, cytostatic agents provedly ineffective in vitro should be avoided.

Antineoplastic Agents↗
PubMed1975

[Biological validity, cytodiagnosis, and therapy of cervix dysplasia].

Certain forms of dysplasia are biologically equal to carcinoma in situ and should be treated alike. The persistance of the state during the permanent cytologic control is to be regarded as criterion for the treatment of middle and even the slight dysplasia. Slides of cells indicating a dysplasia are therefore placed in a cytologic risk-group III D. If the restoration of the cytologic state cannot be observed within 12 months, the conisation as carcinoma prophylaxis of slight and middle forms of dysplasia should be performed.

Carcinoma in Situ↗