[Sponge kidney and urinary calculi].
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Biomedical subjects
Publications and source records attributed to K Bandhauer.
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Acute urinary retention without subvesical obstruction is associated with neurogenic or nonneurogenic disorders of bladder function. Urodynamic investigations differentiates sensoric and/or motoric disturbances of the micturation. Neurologic and laboratory examinations are necessary to clear the etiology. Symptomatic urological treatment and specific etiological therapy should be used to manage this entity.
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The case is presented of a 29-year-old male who developed embryonal testicular carcinoma two months after successful transplantation of a cadaver kidney because of end stage renal disease due to polycystic disease. After surgical removal of the carcinoma and 3 courses of chemotherapy with bleomycin and vinblastine, complete remission was induced which has now lasted for 14 months. In addition to the usual toxicity of cytotoxic therapy, transplant function decreased intermittently but renal function recovered under close monitoring and dose-adaptation of immunosuppressive medication with cyclosporin and prednisolone.
In 11 adults with ileal conduits, urodynamic, radiologic and radioisotope studies were performed. Under physiological conditions the conduits revealed a low-volume/low-pressure state due to continuous drainage of urine by passive and active mechanisms. Conduito-renal reflux was found in all patients under high pressure conditions, such as having the patient cough and strain, or with the conduit filled up to maximum capacity after blockage of the stoma. The 'physiological' low-volume/short-term reflux obviously did not harm kidney function, as shown by radiologic and isotope studies.
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Therapeutic considerations for prostatic cancer are determined by the stage and the differentiation of the tumor and by the patient's age. Local treatment (radical prostatovesiculectomy, external or interstitial irradiation) is reserved for T1-T2 N0 M0 tumors. The best cure rate in these tumor stages achieves the radical prostatectomy, which is indicated up to the 70th year of life, provided a good general condition. Impotentia after radical prostatectomy appears in almost 100% while urinary incontinence occurs in about 5%. External or interstitial irradiation can also be used in stage T1-T3 N0 M0, if radical surgery is not possible. The 5- and 10-year survival rate after high voltage or interstitial radiation therapy for stage T1-T2 reaches up to 75% and 47%, respectively, while for stage T3 the survival rate lies between 50% after 5 years and 30% after 10 years. Prostatic cancer proceeding across the border line of the prostate or metastasizing tumors can be treated by systemic therapy modalities. The contrasexual therapy (orchiectomy with or without estrogens) and the employment of antiandrogens are palliative methods. The efficacy of these therapy modalities depends on the hormone receptors in the neoplastic tissue, although these receptors are difficult to prove until now. Cytostatics are used in hormone resistant tumors, but the success rate is rather low. Adjuvant procedures (hypophysectomy and bilateral adrenalectomy) are of no importance anymore. Hyperprolactinemia is an indication for bromocriptine, and cortisone can reduce pain by reduction of perimetastatic edemas.(ABSTRACT TRUNCATED AT 250 WORDS)
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In 7 patients with acute unilateral testicular torsion, bilateral orchiopexy was performed and biopsies were made at the same time for the purpose of light microscopic (semi-thin section method) and electron microscopic examination. All tissue specimens from the twisted and non-twisted gonads showed changes in the form of tubular atrophy, atrophy of the Leydig cells and malformation at the spermatid level. The results indicate primary tissue damage of the testicles, which was already present before torsion occurred. Nevertheless, it is not possible, on the basis of the these findings, to determine definitely whether the disorders of spermiogenesis frequently found in unilateral testicular torsion are the result of possible congenital dysplasia or damage to the germinal epithelium caused by recurrent subtorsion.
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Testicular ectopia in adults: Postpuberal ectopic testes are seen in about 0.8% of the male population thus being identical in frequency as after the first year of life. Based on our own experience with 32 cases between 1970 and 1979 the significant features of the diagnosis, potential development of malignancy, coincident subfertility and treatment are outlined: 1. In contrast to the situation of early childhood, missing puberal development during early adulthood is always indicative of absent endocrinologically active testis parenchyma. 2. Routine diagnostic work-up includes selective gonadal venography, sonography and CT-scanning may also be of diagnostic help. 3. The risk of tumor development is higher in undescendent as compared to normotopic testes preferably in abdominal ectopia; orchiopexy after the 6th year of life is not preventive in this regard. 4. Unilateral cryptorchism is associated with infertility, the exact cause is obscure, pathological changes are also seen in the contralateral normotopic testis and orchiopexy after the 2nd year of life does not improve spermatogenesis. 5. The therapeutical concept should be oriented on the patient's individual cosmetic and psychological needs and requirements in cases of testicular ablation or orchiopexy and should take, at the same time, the potential risk of malignancy into consideration. Testes prosthesis is an accept able means; in cases in which orchiopexy is easily achieved testis biopsy should be performed to rule out carcinoma in situ. Endocrine work-up is essential to characterize hormone insufficiency and to enable proper substitution.
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From the examinations may be concluded that the cellular immune response to the unspecific DNCB skin test correlates quite well with the survival time. With the quantification of the test reaction in after-testings comparisons may be rendered, so that by this means already pretty early conclusion may be made on the further course of the disease. For a definitive judgment, however, the numbers of cases got up to now are still too small.
The clinical control of patients with T1--T3, N0--M0 prostatic carcinomas allows us to draw the following conclusions regarding the grading. (1) The grading of the primary tumor is of great help in establishing the prognosis. (2) The results of the various applied treatments, like radical prostatectomy, radiation, and heterosexual hormone therapy, depend on the primary grade. The use of cytostatics in badly or undifferentiated prostatic carcinomas deserves on the contrary, better attention. (3) The changing of the grading at the various check-ups is of great therapeutical significance.