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Biomedical subjects

K Ayed

Publications and source records attributed to K Ayed.

143 records · Page 8Linked to original sources
PubMedDate not supplied

[IgM multiple myeloma (author's transl)].

A new case of IgM myeloma in a 47-year-old man is reported. Multiple myeloma was diagnosed by serum electrophoresis and immunoelectrophoresis, marrow plasmocytosis and typical skeletal changes by X - Ray the synthesis of the M - component was demonstrated in the plasma cells of the bone marrow by direct immunofluorescence study. A review of literature was done and relation between macroglobulinemia of Waldenström and IgM myeloma was discussed.

Fluorescent Antibody Technique↗
PubMedDate not supplied

[Seroimmunological profile of kala-azar in Tunisia].

165 sera of patients suffering from kala-azar were collected before and after treatment (N-methyl glucamine: Glucantime ) and analysed for anti-leishmania antibodies by the counter immunoelectrophoresis and fluorescent antibody techniques. Serum immunoglobulins G, A, M and Complement C4 and C3 were studied as well; and C reactive protein, rheumatoid factor and anti-nuclear, anti-mitochondrial and anti-smooth muscle antibodies were investigated. Before treatment, counter immuno-electrophoresis was positive in 63.88% and immunofluorescent antibody test in 94.6%. The analysis of immunoglobulins has shown an increase of IgG in nearly all cases, an increase of IgM in 78.26% of sera tested. Little change has been noted with IgA. C reactive protein has been found in 87.67% and rheumatoid factor in 76.4% of sera examined. In 4 patients, anti-smooth muscle antibodies have been found at a relatively weak dilution. A decrease of complement C4 has been observed whereas complement C3 was slightly increased. After treatment (2 cures of Glucantime ) counter immunoelectrophoresis was positive in 23.07% of cases whereas immunofluorescent antibody test was still positive in 84.62%. IgG remained increases in the whole cases and IgM in only 43,48%. C reactive protein and rheumatoid factor have been found in 14.81% and 50% of cases respectively. Complement C4 remained low whereas complement C3 showed normal mean value. The relationship between the serological disturbances observed and the prognosis were discussed.

Antibodies↗
PubMedDate not supplied

Complement studies in BN rats with mercuric chloride-induced immune glomerulonephritis.

Whole complement haemolytic activity (CH50) changes were examined in 71 rats, developing and HgCl2-induced biphasic immune glomerulonephritis. In some rats, serum C4 level was also studied. Whole CH50 level was compared with proteinuria and C3 glomerular deposits. In control rats or in rats injected with low doses of HgCl2, there was no complement decrease. In rats injected with a high dose, after an initial increase (also observed in controls), CH50 level decreased between day 12 and day 20, sometimes dramatically. This decrease, observed during the first phase, was transient, CH50 levels returning to normal before day 30. Serum C4 level varied in accordance with CH50, indicating a classical pathway activation of complement. Fall in CH 50 and proteinuria was correlated: the heavier the proteinuria, the greater the fall in complement (p < 0.01). Whether proteinuria is or is not the consequence of the complement activation, remains to be demonstrated.

Animals↗