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Biomedical subjects

K Aspegren

Publications and source records attributed to K Aspegren.

49 records · Page 3Linked to original sources
PubMed1978

Quantitative lymphoscintigraphy for detection of metastases to the internal mammary lymph nodes. Biokinetics of 99Tcm-sulphur colloid uptake and correlation with microscopy.

Dymanic quantitative activity determination and accurate scintigraphic localization of parasternal lymph nodes were obtained from antero-posterior measurements with a scintillation camera. The scintigraphic observations were compared with microscopy of the nodes removed at operation. The 99Tcm-sulphur colloid indicated a high frequency (7/16) of absent uptake in normal lymph nodes. However, the technique used indicates that a similar technique with smaller particle size may be a useful method for proper classification of the clinical stage of carcinoma of the breast.

Breast Neoplasms↗
PubMed1977

In vitro effects of prolactin and hydrocortisone on 7,12-DMBA-induced mammary tumour and virus-induced sarcoma in the rat.

The in vitro effect of prolactin and hydrocortisone, singly or in combination, on the DMBA-induced mammary tumour in the rat was investigated by organ cultures. Prolactin had a stimulating effect on the DNA synthesis in one out of five tumours. Hydrocortisone induced lobulo-alveolar differentiation but reduced the DNA synthesis or failed to affect it. The addition of prolactin to hydrocortisone did not alter this response. Virus induced rat sarcomas were studied as control tissue. Prolactin inhibited growth of one sarcoma. Hydrocortisone stimulated growth of sarcomas. The relevance of these findings in relation to similar in vitro experiments is discussed.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1977

In vitro responsiveness of human gastric carcinoma to pentagastrin.

The influence of pentagastrin on thymidine incorporation of five human gastric carcinomas was studied by an in vitro short-term cell suspension technique. Two of the five tumours reacted with stimulation of incorporation to the treatment. Five tumours of other aetiology did not react to similar treatment. The possibility of gastric carcinoma as a hormone-sensitive tumour is discussed.

Breast Neoplasms↗
PubMed1976

Hormone effects on human mammary cancer in organ cultures.

Specimens of human breast cancers and fibrosarcomas were incubated for 4 to 72 hours as organ cultures. The effect of various concentrations of testosterone, progesterone, and 17-beta-estradiol on cell survival and multiplication was measured as changes in incorporation of H3-TdR into DNA. Both types of tumor reacted to the hormones; both stimulations and inhibitions were recorded. Statistical analysis of data demonstrated possible influence of factors other than hormone treatment. The specificity of hormone sensitivity assays in vitro is questioned.

Adenocarcinoma, Scirrhous↗
PubMed1976

Heterogeneity in in vitro response to progesterone and melphalan of mammary tumours induced in the rat by 7,12-DMBA.

Five mammary tumours induced in rats by 7, 12-DMBA were each divided into four sections, and studied as cell suspensions in vitro for response to melphalan or progesterone measured as H3-thymidine incorporation. Heterogeneity towards melphalan and progesterone was found within all five tumours, but the mode of reaction of the two drugs differed. The biological relevance of these findings is discussed.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1976

Specificity of hormonal responsiveness in vitro. Effect of sex steroids on non-malignant rat cells compared with the effect on cells from rat tumours.

Since mammary tumours and sarcomas in the rat both have been shown to be sensitive to steroid hormone in vitro, a search for a non-steroid sensitive rat tissue was made. Neonatal cerebellar medulloblasts in the rat did not respond to high concentrations of steroids if cultured as organ culture. The relevance of this finding to the specificity of steroid response assays in vitro is discussed.

Animals↗
PubMed1975

7,12-DMBA induced rat mammary tumour studied for hormonal responsiveness in vitro. 2. Organ cultures.

Specimens of DMBA-induced mammary tumour, DMBA-induced subcutaneous sarcomas, and virus induced sarcomas in the rat were incubated for 24-72 hours as organ cultures. The effect of various concentrations of testosterone, progesterone, and 17-beta-oestradiol on cell survival and multiplication was measured as changes in incorporation of H3-TdR into DNA. All three types of tumour reacted to the hormones. Statistical analysis of data demonstrated possible influence of factors other than hormone treatment. The specificity of hormone sensitivity assays in vitro is questioned.

Animals↗
PubMedDate not supplied

Combined therapy for undifferentiated giant and spindle cell carcinoma of the thyroid.

Undifferentiated giant and spindle cell carcinoma is an unusual and high-grade malignant type of cancer of the thyroid. The results of surgical and/or radiotherapeutic treatment have been discouraging. Only a few patients respond to therapy, usually for a short time. Recently, a few reports have been published on the effect of chemotherapy or a combined treatment of surgery, radiotherapy and chemotherapy. In the present paper the results of combining radiotherapy and chemotherapy, 5-FU and cyclophosphamide, are reported. For the future a more aggressive approach is discussed. The therapy should include surgical resection of the main bulk of the tumour, followed by radiotherapy and concomitant chemotherapy and thereafter prolonged adjuvant chemotherapy.

Aged↗
PubMedDate not supplied

Survival in breast cancer and age at start of oral contraceptive usage.

In general, findings in studies on oral contraceptives (OCs) and breast cancer have not indicated prognosis to be worse among users of OCs. In few studies, however, has age at the start of OC usage been considered as a prognostic factor. In the present study, prognosis in breast cancer is compared with OC usage, particularly with age at the start of OC usage, among 193 consecutive patients at the Department of Oncology, University Hospital, Lund. An earlier series of 193 breast cancer patients at Malmö General Hospital is included for comparisons. In the Lund series, five-year survival was 62% among women who started to use OCs before the age of 20.78% among those who started to use OCs between the ages of 20 and 25, and 86% among non-users and those who started to use OCs after the age of 25 (p = 0.009, test for homogeneity). Although age was found to be a prognostic factor in the Lund series (RR = 0.90, p = 0.001), this was not so in the earlier (older) Malmö series. The relationship with age differed significantly between the two series (p = 0.003), suggesting the apparent effect of age at diagnosis to be a cohort effect due to the introduction of OCs during the 'sixties. The age-specific relationship between survival and OC usage would seem to indicate the presence of a biological mechanism in which OCs may participate during precancerous and early stages of breast cancer.

Adult↗
PubMedDate not supplied

Increased plasma prolactin levels in a group of men with breast cancer--a preliminary study.

Gonadal and hypophyseal hormones were investigated in 15 males with breast cancer and 15 tumour referents, on average 1 month postoperatively. Plasma prolactin was found to be significantly more often elevated in men with breast cancer compared with referents (p less than 0.005). Another group of men with breast cancer disclosed a tendency for lower S-FSH levels compared with the referents (p less than 0.01). No significant difference was seen between cases and referents regarding S-LH, p-estradiol or p-testosterone. The size of the primary breast tumour was correlated with a higher prolactin level. The findings lend support to a theory implicating prolactin and possibly prolactinomas as a risk factor for the disease in males.

Aged↗