Inferior caval occlusion associated with the Budd-Chiari-syndrome: treatment with bypass operation.
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Budd-Chiari Syndrome↗
Biomedical subjects
K Asano
Publications and source records attributed to K Asano.
Aortoatrioplasty with double valve replacement for infective endocarditis.
This is a report of a patient with active infective endocarditis involving both aortic and mitral valve annuli. A new surgical technique which was necessary to replace the infected valves is described in detail. This may be regarded as an application of the Manouguian technique to infective endocarditis.
Adult↗
Clinical experience of Hall-Kaster valve. Operative results and hemodynamic studies.
The Hall-Kaster pivotal disc prosthetic valve (HK valve) was introduced in 1977. Since October 1979, we have used the HK valve in 137 patients for valve replacement. The over-all operative mortality was 5.1%. During 36 months follow-up, there were 3 late deaths due to congestive heart failure, but no valve related death, no mechanical failure and no thromboembolic episode have been encountered. Intraoperative hemodynamic studies revealed its valvular function to be excellent. The mean pressure gradients across the prosthesis were 11.0 +/- 1.6 and 4.2 +/- 2.0 mmHg in aortic and mitral position, respectively. The mean calculated valve areas were 1.7 +/- 0.6 and 3.7 +/- 1.2 cm2 in aortic and mitral position, respectively. Thus, the Hall-Kaster prosthetic valve was found to be an efficient and favorable prosthetic heart valve for aortic and mitral valve replacement.
Adolescent↗
Surgical treatment of syphilitic coronary ostial stenosis with aortic regurgitation.
Syphilitic aortitis leads to involvement of the coronary ostia, aortic annulus and valve leaflets. Aortic valve replacement (AVR) with restoration of coronary blood flow is an essential therapeutic objective. Three different approaches were used for the treatment of syphilitic aortic regurgitation with coronary ostial stenosis; Case 1. AVR and endarterectomy, Case 2. AVR and aorto-coronary saphenous vein bypass graft and Case 3. AVR and endarterectomy using Fogarty catheter and Scanlan Aorta Punch. Special emphasis was given to the technique used in Case 3 as a therapeutic adjunct in the treatment of syphilitic coronary ostial stenosis.
Aortic Valve Insufficiency↗
Postoperative hemolysis and its prevention in corrective surgery of truncus arteriosus.
Two cases of truncus arteriosus type I associated with truncal valve insufficiency were operated upon with the Rastelli's procedure. The first case of 3-year-old boy died from severe hemolysis which was caused by the regurgitant jet from the truncal valve running against the rough-surfaced Dacron patch for the VSD. The second case of 12-month-old girl was treated with a Dacron patch lined with an autologous pericardial pedicle. Her postoperative course was uneventful. The authors discuss the potential risk and prevention of postoperative hemolysis in corrective surgery of the truncus arteriosus with truncal valve insufficiency.
Child, Preschool↗
Effect of Y-25130, a selective 5-hydroxytryptamine3 receptor antagonist, on gastric emptying in mice.
The effect of Y-25130 on gastric emptying of nutrient test meals (solid chow) was examined in mice. In a dose range of 0.01-1 mg/kg, p.o., Y-25130 significantly accelerated gastric emptying of solid meals in a dose-dependent manner, at an ED30 of 0.021 mg/kg. Other 5-hydroxytryptamine3 receptor antagonists and prokinetic agents having 5-hydroxytryptamine3 receptor antagonistic properties accelerated the emptying of solid meals in the following rank order of potency: Y-25130 = granisetron > or = tropisetron > ondansetron > cisapride > metoclopramide. The acceleration of the gastric emptying showed a good correlation with the antagonistic potencies of these compounds on 5-hydroxytryptamine3 receptors, determined by the inhibition test of the von Bezold-Jarisch reflex in anesthetized rats (r2 = 0.99). Domperidone (1 and 10 mg/kg, p.o.) and trimebutine (10 and 100 mg/kg, p.o.) failed to increase the rate of emptying from the stomach. Cisplatin (30 mg/kg, i.p.), a chemotherapeutic agent, significantly delayed the gastric emptying of solid meals, and Y-25130 (0.1-1 mg/kg, p.o.) prevented such a delay in emptying in a dose-dependent manner. These results suggest that Y-25130 accelerates the gastric emptying in mice by antagonism of the 5-hydroxytryptamine3 receptor.
Animals↗
Modulation of cytokine secretion by mesenteric lymph node cells from vitamin A-deficient mice during Hymenolepis nana infection.
The influence of vitamin A deficiency on the development of cellular immune responses was examined using vitamin A-deficient mice (A mice)/Hymenolepis nana system. Mesenteric lymph node cells (MLNC) prepared from both normal BALB/c mice and A mice during H. nana infection proliferated extensively when cultured with soluble egg antigen of H. nana as assessed by 3H-thymidine incorporation. MLNC from normal mice secreted significantly more IL-2 and significantly less IFN-gamma than A mice when the cells were cultured in the presence of soluble egg antigen.
Animals↗
A surgical treatment with an "on-lay" patch for experimental myocardial infarction.
The authors proposed a new operative method for acute myocardial infarction with a prosthetic "on-lay" patch in a dog model, and functional and morphological studies were made in the acute and long survival dogs. In this method, the following advantages were observed: Improvement of cardiac functions, reduction of mortality, prevention of ventricular aneurysm, prevention of the occurrence of arrhythmias and ventricular fibrillation, minimum reduction of the intracardiac capacity and no suture dehiscence resulting in cardiac rupture. It is shown that this surgical method can be applied securely to the emergent cases of acute myocardial infarction failing to respond to medical therapy.
Acute Disease↗
Changes of IgE production in senescence-accelerated mice SAMP8.
The IgE production and proliferation activity of spleen B cells were studied in vivo in 2 approximately 3-month-old (designated as young) and 12 approximately 13-month-old (designated as old) senescence-accelerated mice (SAMP8) employing age-matched AKR mice, the origin of the SAM strain, as controls. After the secondary immunization with 2,4-dinitrophenylovalbumin conjugate (DNP-OVA) with aluminum hydroxide gel (alum) as an adjuvant, the serum IgE levels were significantly reduced in old SAMP8 compared to young SAMP8 mice, but there were no changes in AKR. However, old SAMP8 mice had a proliferative activity of spleen B cells comparable to that found in young SAMP8; proliferative activity was measured by 3H-thymidine incorporation into the spleen after stimulation with water extract from wood chips of coniferous splash pine (pine wood extract) as a mitogen. These data indicate that a decline in IgE production is a characteristic phenomenon of SAMP8 mice and was not due to the functional deficiency of B cells with aging.
Aging↗
Mode of action of FK-506 on protective immunity to Hymenolepis nana in mice.
FK-506 (Tacrolimus) has been shown to block T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially interleukin (IL)-2, but little direct evidence is available to support the view that the immunosuppressive effects of FK-506 in vivo are mediated by a similar inhibition of lymphokine cascade. To investigate the mechanisms of FK-506-induced immunosuppression, the effects of FK-506 on cell-mediated immunity to Hymenolepis nana were examined in mice. FK-506 administration into BALB/c mice daily at a dose of 10.0 mg/kg (but not 5.0 mg/kg) for 5 days caused suppression of protective immunity against H. nana challenge infection. During the infection of mice with H. nana, IL-2 and interferon (IFN)-gama were produced by mesenteric lymph node (MLN) cells with a time course corresponding to that of MLN T cell proliferation. These responses were completely suppressed by repeated administration of FK-506 for 5 days at a dose of 10.0 mg/kg/day (but not 5.0 mg/kg/day). In contrast to the effects of FK-506 on IL-2 and IFN-gamma productions in MLN, IL-1 and tumor necrosis factor-alpha in the intestinal wall, which were enhanced by H. nana infection, were not completely decreased as a result of 10.0 mg/kg FK-506 treatment. The reverse transcriptase-PCR revealed complete inhibition of IL-2 and IFN-gamma mRNA expression on mesenteric L3T4+ cells that were induced by H. nana infection, when mice were given 10.0 mg/kg/day FK-506 for 5 days. These results strongly suggest that FK-506 affects cell-mediated immunity in vivo with mechanisms similar to those observed in vitro.
Animals↗
Induction of apoptotic cell death in human leukemic cell line, HL-60, by extremely low frequency electric magnetic fields: analysis of the possible mechanisms in vitro.
The influence of extremely low frequency electric magnetic fields. (ELF EMFs) on apoptotic cell death was examined using a human leukemic cell line, HL-60 and normal human peripheral blood leukocytes. When HL-60 cells were exposed to 45 mT ELF EMFs, apoptotic cell death, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that were multiples of 180-200 base pairs, were induced. The minimum periods required apoptotic HL-60 cell death was 1.0 hour. However, exposure to ELF EMFs could not produce detectable DNA fragmentation in human peripheral blood leukocytes. Static magnetic fields could not induce apoptotic cell death in HL-60 cells, even when the cells were exposed to 180 mT of magnetism for 3.5 hours. We further examined whether hyperthermia induced by induction current in ELF EMFs produced apoptosis in HL-60 cells. Induction current in ELF EMFs enhanced temperature of culture medium to 40.3 degrees C at 3.0 hours of exposure. However, this level of temperature could not induced apoptotic cell death in HL-60 cells, even when cells were cultured for 3.5 hours. These results suggest that induction current produced by ELF EMFs may be one of main mediator in apoptosis in HL-60 cells.
Apoptosis↗
Rapid determination of ascorbate by ESR spectroscopy.
Optimal conditions for the determination of ascorbate, based on the detection of its radical by ESR spectroscopy, were established. The optimal pH for the measurement of the ascorbate radical was 10, whereas that for the gallate and caffeate radical was much higher. This was due to the liability of the ascorbate radical at higher pH. When the radical intensity of ascorbate vs. concentration was plotted double logarithmically, a linear correlation was established between these two parameters within the ascorbate concentration of 0.03-10 mM. ESR analysis of the homogenates under alkaline condition demonstrated that ascorbate is distributed in various mouse organs and that the ascorbate radical is unstable at neutral pH in the brain and liver, suggesting the presence of metabolizing substances. The present study suggests the applicability of the present technique for the study of ascorbate metabolism and identification of physiological factors which regulate the radical intensity of ascorbate.
Animals↗
Effect of physiological fluids on radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate.
The effect of various physiological fluids on the radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated using ESR spectroscopy. Blood from various animals did not significantly affect the radical intensity of both ascorbates, whereas the corresponding plasma fractions significantly enhanced the radical intensity. This suggests that some populations of blood cells might modify the interaction between plasma components and ascorbates. Saliva contained labile substance(s) which effectively reduced the ascorbate radical intensity. HPLC demonstrated the presence of endogenous ascorbate in rat liver and brain homogenates. When sodium ascorbate or SBA was incubated with any of these homogenates, their radical intensity was synergistically enhanced, but abruptly declined without any apparent ascorbate degradation. Incubation with homogenates elevated the radical intensity of SBA up to the level significantly higher than that of sodium ascorbate. The present data suggest that antitumor action of SBA might be mediated via the accelerated production of ascorbate radical in the target organ.
Animals↗
Role of hydrogen peroxide for cell death induction by sodium 5,6-benzylidene-L-ascorbate.
The role of hydrogen peroxide in the induction of cell death in human promyelocytic leukemic HL-60 cells by sodium 5,6-benzylidene-L-ascorbate (SBA) and its degradation product, ascorbic acid, was investigated. Millimolar concentrations of these compounds induced cell death, characterized by cell shrinkage, nuclear and internucleosomal DNA fragmentation, disappearance of microvilli and condensation of chromatin near the nuclear membrane. Catalase significantly reduced the cytotoxic activity of these compounds, whereas superoxide dismutase, nitric oxide (NO) generator, NO scavenger and NO synthase inhibitor were inactive, suggesting the possible role of H2O2. Determination of H2O2 with the peroxyoxalate chemiluminescence demonstrated that sodium ascorbate and SBA produced H2O2 in amounts necessary for cell death induction.
Antineoplastic Agents↗
Role of hydrogen peroxide in antitumor activity induction by sodium 5,6-benzylidene-L-ascorbate.
Role of hydrogen peroxide (H2O2) in the induction of antitumor activity against chemically-induced rat hepatocellular carcinoma by sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated. ESR spectroscopy demonstrated that rat liver homogenate of cancerous tissue significantly enhanced the radical intensity of SBA more potently than that of precancerous or normal tissue. The peroxyoxalate chemiluminescence method demonstrated that SBA significantly enhanced the production of H2O2-derived chemiluminescence intensity in the liver homogenates, and the effect of SBA was greater in cancerous tissue than in precancerous or normal tissue. Addition of ascorbic acid, a degradation product of SBA, showed similar but slightly weaker stimulation effects. These data suggest that antitumor activity of SBA in vivo might, at least in part, be due to H2O2 production.
Animals↗
Antipyretic action of peripheral stimulation with electroacupuncture in rats.
The present study was designed to investigate the antipyretic action of peripheral stimulation with electroacupuncture (EA) in SD rats. EA stimulation was applied for 30 min to the peripheral muscle where the equivalent Quchi (LI11) acupoint is located. We first examined the effects of EA stimulation on fever induced by either lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta) or prostaglandin E2 (PGE2). Intraperitoneal injection of LPS at a dose of 100 micrograms/kg caused a high rectal temperature, which was suppressed by EA stimulation. EA stimulation also inhibited the development of fever induced by IL-1 beta injection either intravenously or into the preoptic area (POA). The rats that received administration of PGE2 into POA developed rapid and high fevers, which were attenuated by EA stimulation. In the second part of the experiment, we investigated the levels of cytokines and PGE2 during the development of fever. The concentrations of IL-6 and PGE2 but not IL-1 beta, in brain and serum were increased by intraperitoneal injection of 100 micrograms/kg LPS. EA stimulation reduced PGE2 levels in both brain and serum in LPS-injected rats, but failed to change the levels of IL-6. Intravenous injection of IL-1 beta produced high brain and serum PGE2 levels, which were also significantly suppressed by EA stimulation. The results suggest that EA stimulation possesses an antipyretic effect through the inhibition of the action of PGE2 in rats.
Acupuncture Therapy↗