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Biomedical subjects

K Asakura

Publications and source records attributed to K Asakura.

At least 199 records · Page 11Linked to original sources
PubMed1984

Cyclic nucleotide levels of nasal secretions in allergic patients and control subjects.

Cyclic nucleotides (CND) levels of nasal secretions were studied in allergic rhinitis patients and control subjects. In methacholine-induced nasal secretion, allergic rhinitis patients had lower cAMP levels, higher cGMP levels and a lower cAMP/cGMP ratio than the control subjects. A close relationship was found between CND levels and the severity of daily symptoms in both methacholine-induced and antigen-induced nasal secretions.

Cyclic AMP↗
PubMed1984

Nasal responsiveness to methacholine stimulation in allergic rhinitis patients.

We examined the nasal responsiveness to topical methacholine application in allergic rhinitis and non-allergic chronic rhinitis patients, and in control subjects. Methacholine responsiveness was significantly higher in allergic rhinitis patients than in non-allergic patients and control subjects. In perennial rhinitis, methacholine responsiveness correlated with the severity of daily nasal symptoms and those provoked by specific allergen challenge tests. Among nasal symptoms, hyper-rhinorrhoea was found to be closely related to methacholine responsiveness. As a result of these findings, the possibility of cholinergic hyper-reactivity in allergic rhinitis patients is discussed.

Administration, Topical↗
PubMed1984

[Application of radiofrequency hyperthermia for treating advanced urinary bladder cancer--a case report].

A patient with advanced urinary bladder cancer treated with a combination of radiation and hyperthermia, using short-wave radiofrequency (RF) and intravesical irrigation with warm water is reported. The tumor temperature was successfully maintained at 43 degrees to 44.6 degrees by external application of 13.56 MHZ RF when the bladder was irrigated with heated saline (intravesical temperature: 43 degrees) Hyperthermia was performed for 30 min immediately after each course of external bladder irradiation (Linac: 400 rad, twice a week; total 5 weeks exposure of 4000 rad). The tumor disappeared completely (CR) after the completion of the combination therapy.

Aged↗
PubMed1982

Ultrastructure and chloride cytochemistry of the hindgut epithelium in the larvae of the seawater mosquito, Aëdes togoi Theobald.

The hindgut of Aëdes togoi larvae adapted to various external salinities was studied by light and electron microscopy. The larvae's pyloric chamber and the ileum of the hindgut are surrounded by a thick muscular layer and lined with a very thin unspecialized epithelium. There is no detectable difference in the ultrastructural organization of the epithelium between seawater-adapted and freshwater-adapted larvae. The rectum and the anal canal are greatly dilated and densely tracheated and have a very thick, highly specialized epithelium. The rectal epithelium is characterized by shorter apical and longer basal infoldings closely associated with mitochondria, and a particulate coating on the apical infoldings. The intercellular spaces and the basal channels are tightly closed in the rectal epithelium of freshwater-adapted larvae, whereas widely dilated in that of 100 to 200% seawater-adapted larvae. The rectum seems to reabsorb water from excretory fluid when larvae are in hyperosmotic media. The anal canal epithelium possesses well-developed apical infoldings, which are coated with small particles an intimately associated with mitochondria. The basal infoldings are short. No perceptible difference in the ultrastructural organization of the epithelium was observed between seawater-adapted and freshwater-adapted larvae. The lumina of the apical infoldings of the anal canal epithelium in seawater-adapted larvae, however, demonstrated a strongly positive reaction to the cytochemical assay for chloride ions, whereas the reaction was very weak in freshwater-adapted larvae. Unlike salt-water-mosquito larvae of the other species, in which the rectum is considered to be concerned with the formation of hyperosmotic urine, the anal canal in A. togoi larvae seems to play an important role in excretion of excess ions in the haemolymph when adapted to hyperosmotic media.

Aedes↗
PubMed1980

cAMP and cGMP in the human parotid saliva.

Human parotid saliva was revealed to contain considerable amounts of cAMP and cGMP. On sour lemon drop stimulation, the salivary cyclic nucleotides concentration decreased and the cyclic nucleotides secretory rate increased in close relationship with the salivary flow rate in control subjects. On feeding, both cAMP concentration and secretory rate increased significantly in control subjects. Parotid saliva from a patient of Sjögren's syndrom was revealed to have a significantly higher of cGMP concentration than those from control subjects. Saliva derived from the malignant tumor of the parotid gland was revealed to have a higher cGMP concentration and a lower cAMP concentration than the healthy site. From these findings, the possibilities of the clinical usefulness of studying salivary cyclic nucleotides were discussed.

Adult↗
PubMed1979

Metabolism of cyclic nucleotides in allergic rhinitis: studies on lymphocytes, granulocytes, and plasma level.

The effect of isoproterenol on the cyclic nucleotide level in peripheral lymphocytes and granulocytes with allergic rhinitis patients and normal subjects has been studied. Responsiveness to 10(-5) M isoproterenol of lymphocytes decreased in the case of allergic rhinitis patients. When asthma was complicated to perennial rhinitis, a more significant depression was noted. In granulocytes the same tendency as with lymphocytes was noted although the difference was not significant. Basal level and responsiveness to 5 X 10(-3) M theophylline of both lymphocytes and granulocytes were similar in allergic rhinitis patients to normal subjects. The ratio of plasma cAMP to cGMP concentration was lower in the allergic rhinitis patients although the difference was not significant.

Adolescent↗