Biomedical subjects

K Aragane

Publications and source records attributed to K Aragane.

22 records · Page 2Linked to original sources

PubMed1995

Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats.

In the present study, we investigated the hypocholesterolemic effect of F-1394 ((1s,2s)-2-[3-(2,2-dimethylpropyl)-3-nonylureido]aminocycloh exane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propionate), a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), and the effect on cholesterol absorption via the gut in rats fed a 1% cholesterol diet. Single administration of F-1394 to the cholesterol diet-fed rats at the doses of 3-30 mg/kg, p.o. decreased the serum cholesterol levels by 16-54% 3 hr after the administration. The ACAT activity in the small intestinal mucosa of the rats given orally F-1394 (30 mg/kg) was significantly inhibited 3 hr after the administration. The hypocholesterolemic action of F-1394 had a faster onset than that of DL-melinamide or CL-277,083. The study by the dual isotope ratio method showed that F-1394 (30 mg/kg, p.o.) significantly suppressed the dietary cholesterol absorption. Furthermore, in the determination of cholesterol absorption by using 14C-cholesterol as the oral tracer, the administration of F-1394 (30 mg/kg, p.o.) 1 or 2 hr before or immediately after the application of the oral tracer significantly prevented the appearance of the radioactivity in the circulation by around 90%. These results indicate that oral administration of F-1394 inhibits the ACAT activity in the small intestinal mucosa and subsequently contributes much to the prevention of cholesterol absorption via the gut, resulting in the decrease in serum cholesterol levels in the cholesterol diet-fed rats. Furthermore, the effect of F-1394 appears immediately after its administration in contrast to that of DL-melinamide or CL-277,082.

Administration, Oral↗

PubMed1995

Event-related potential components analysis of cognitive impairment in patients with multiple lacunar infarcts.

We measured the visual event-related potentials (ERPs) and reaction time (RT) in 21 patients with multiple lacunar infarcts and in 8 age-equivalent normal subjects. The N2 latency of the infarct patients was significantly longer than that of the normal subjects, although the NA and the P3 latencies and RT did not differ between the two groups. The N2 latency was negatively correlated with the scores of Mini-Mental State Examination or the Hasegawa's dementia scale. These results suggest that the impairment of cognitive information processing in these patients arises from an uncertainty in the classification of a perceived event. In addition, the N2 latency may be more sensitive in detecting cognitive impairment in multiple infarct patients.

Aged↗

PubMed1995

[Visual event-related potentials and reaction time in Parkinson's disease].

Visual event-related potentials (ERPs) and reaction times in 29 patients with nondemented Parkinson's disease and 19 age-equivalent normal control subjects were measured during the physical and semantic discrimination tasks. The components of the NA, N2 and P3 and simple and choice reaction times were observed in both kinds of discrimination tasks. There were no significant differences in either the latency or amplitude of the ERP components (NA, N2 and P3) between the Parkinson's disease patients and normal subjects during the physical discrimination tasks, but the patients had significantly prolonged choice reaction time compared with the normal controls. During the semantic discrimination tasks, the N2 and P3 latencies and choice reaction time in patients with Parkinson's disease were significantly longer than those of the normal controls, although there were no differences in NA latency between the two groups. There were no significant differences in any of the amplitudes between these groups. These results suggest that motor preparation is delayed in patients with nondemented Parkinson's disease, although the stimulus evaluation process is largely preserved during the physical discrimination tasks. The results obtained from the semantic discrimination tasks are interpreted as electrophysiological signs of disturbance in stimulus classification and attention process in Parkinson's disease. From the automatic/controlled processes, the present results suggest that the automatic processing stage associated with NA may be less impaired than the attention-controlled processing reflected by N2 in patients with Parkinson's disease.

Adult↗

PubMed1993

Chronometrical analysis of event-related potentials and reaction time in patients with multiple lacunar infarcts.

We measured the visual event-related potentials (ERPs) and reaction time (RT) in 31 patients with multiple lacunar infarcts and 18 age-equivalent normal subjects. The N2 and RT latencies of the patients were significantly longer than those of normal subjects, although P2 and P3 latencies did not differ between the two groups. However, the time from N2 to RT did not differ between the two groups. These observations suggest that the impairment of cognitive information processing in these patients arises from an uncertainty in classifying the perceived event, while motor organization time is relatively well preserved. In addition, the N2 latency may be more sensitive in detecting cognitive impairment in such patients.

Aged↗