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Biomedical subjects

K Aoki

Publications and source records attributed to K Aoki.

At least 901 records · Page 50Linked to original sources
PubMed1980

Heat denaturation of serum albumin monitored by 1-anilino-naphthalene-8-sulfonate.

The process of heat denaturation of serum albumin, and the properties of several denatured components of albumin were studied using 1-anilino-naphthalene-8-sulfonate as a probe dye. Like native albumin, these protein species all induce fluorescence of the dye with maximum emission at 470 nm when excited at 380 nm. However, the affinity of albumin for the dye decreased on denaturation. This fluorescent dye bound competitively to both native and denatured albumin with another probe dye, 2-(4'-hydroxyphenylazo)benzoic acid, has a specific absorption band at about 480 nm on binding with native albumin. Fatty acids, such as lauric acid, inhibited the interaction of 1-anilinonaphthalene-8-sulfonate with native albumin, but had little effect on its binding with denatured albumin.

Anilino Naphthalenesulfonates↗
PubMed1980

A criterion for the establishment of a stable polymorphism of higher order with an application to the evolution of polymorphism.

This note gives some further useful properties of the constant fitness selection model for multiple alleles which pertain to the effects of adding a new allele to n preexisting alleles in stable equilibrium. In particular the conditions are derived for the establishment of a stable equilibrium involving all n + 1 alleles. For 3 alleles (i.e. n = 2) I give a complete qualitative solution, including the case of the replacement of one diallelic polymorphism by another. As an application I discuss a possible mechanism for the evolution of polymorphism using Monte Carlo methods similar to Lewontin, Ginzburg and Tuljapurkar (1978).

Alleles↗
PubMed1980

Eccrine poroma.

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Adenoma, Sweat Gland↗
PubMed1980

Relationships between hypothalamic catecholamines, blood pressure and body temperature in spontaneously hypertensive rats.

Rectal temperature, catecholamine contents in the hypothalamus, and blood pressure were measured in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). SHR had a significantly higher rectal temperature than WKY. Noradrenaline contents were lower in SHR than WKY. Noradrenaline was inversely correlated with the blood pressure and body temperature in SHR. In subgroups of SHR, differences in values of the parameters mentioned above were also observed.

Animals↗
PubMed1980

Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration.

A strain of domestic bacteria, Bifidobacterium bifidum (Lac B), which is nonpathogenic and anerobic, selectively localized and proliferated in several types of mouse tumors following i.v. administration. None of the same bacilli could be detected in the tissues of healthy organs such as the liver, spleen, kidney, lung, blood, bone marrow, and muscle 48 or 96 hr after i.v. administration into tumor-bearing mice. Proliferation of Lac B in the tumor was artifically stimulated by i.p. administration of DDD-H-2s mice of a synthesized disaccharide, lactulose (4-O-beta-D-galactopyranosyl-D-fructofuranose), a sugar which is not metabolized by mammalian tissue cells. Lac B, which survices and proliferates selectively in the tumor following i.v. administration into the tumor-bearing host, should aid in diagnosis and selective therapy for cancer.

Actinomycetaceae↗