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Biomedical subjects

K Antoniades

Publications and source records attributed to K Antoniades.

51 records · Page 3Linked to original sources
PubMed1982

Quantitative estrogen receptor values and growth of carcinoma of the breast before surgical intervention.

Quantitative estrogen receptor (ER) values in patients with breast carcinoma were correlated with the natural history of the disease before surgical intervention. The natural history was expressed as an index of growth. This was determined as a ratio between tumor size (centimeters) and duration of symptoms (weeks). An inverse correlation was found between amount of ER and growth. Tumors with high positive (above 101 fmol/mg/protein) ER values has grown significantly slower (P less than 0.05) than tumors with low positive (below 50 fmol/mg protein) or negative ER values. These two latter groups had a similar natural history. Recognition of the fact that there is slow growth in carcinomas with high ER as well as of the fact that growth is as rapid in carcinomas with low ER levels as it is in carcinomas with negative ER values, demonstrates the importance of quantitative ER determinations, their prognostic value, and their usefulness in planning therapy.

Breast Neoplasms↗
PubMed1979

Correlation of estrogen receptor levels with histology and cytomorphology in human mammary cancer.

Histologic and cytomorphologic features of mammary carcinoma have been correlated with estrogen receptor (ER) levels determined by the dextran-coated charcoal (Scatchard) analysis in 51 primary mammary carcinomas. The results were expressed as follows: ER-positive above and ER-negative below 10 fmol/mg protein and ER-rich above and ER-poor below 250 fmol/g tissue for premenopausal patients (750 fmol for postmenopausal patients). Most lobular carcinomas were ER-positive and ER-rich (84.6%). A similarly high percentage (88.9%) of ER-positive and ER-rich determinations was seen in ductal carcinomas with tubular features, whereas only about half of the remaining ductal tumors were ER-positive or ER-rich. The highest ER values were obtained in the lobular carcinomas and in ductal carcinomas with tubular features. Three cytomorphologic indices independent of variation in tumor histology showed a strong correlation with ER values: maximal epithelial cellularity of the tumor (P less than 0.001); cellular size (P less than 0.05); nuclear size (P less than 0.05).

Adult↗
PubMed1978

Pseudomembranous colitis associated with ampicillin and erythromycin therapy: report of a case.

Pseudomembranous colitis has been observed increasingly often after therapy with several antibiotics. This report describes the case of a patient in whom pseudomembranous colitis developed in association with ampicillin, an extremely rare complication of this drug, and erythromycin, a drug that has not been previously reported to cause the disease. Clinical and pathologic features, pathogenesis, and management are discussed. Early diagnosis and treatment are extremely important to reduce the significant morbidity and mortality associated with this disorder.

Aged↗
PubMed1977

Familial testicular cancer in a father (bilateral seminoma-embryonal cell carcinoma) and son (teratocarcinoma): a case report and review of the literature.

Familial testicular neoplasia is reported in a father and his son. This represents only the fifth published case of father-son testicular cancer. The father had bilateral testicular seminoma with embryonal cell elements while the son had teratocarcinoma. The clinical significance of familial testicular neoplasia is discussed and the subject of father and son testicular cancer is reviewed. This case of father-son testicular neoplasia illustrates the following important points: 1) there is a continuing need to document and describe each case of familial testicular cancer in order to better evaluate the pathogenesis of this familial occurrence; 2) prospective genetic and laboratory studies will be needed to definitively clarify the specific factors involved in the familial clustering or transmission of this type of cancer; and 3) this tendency for testicular cancer to affect multiple kindred must be considered in the proper guidance and counseling of affected patients and their high-risk family members.

Adult↗
PubMed1977

Prophylactic oophorectomy in conjunction with large-bowl resection for cancer: report of two cases.

This report, based on eight cases of our own and a review of the literature, indicates that colonic cancer metastatic to the ovaries has many unusual features and an extremley high mortality rate. Prophylactic bilateral oophorectomy in conjunction with large-bowel resection for cancer in women of all ages is strongly advised to decrease morbidity and improve the quality of survival.

Adenocarcinoma↗
PubMed1976

Conversion of a benign lymphoepithelial salivary gland lesion to lymphocytic lymphoma during dilantin therapy: correlation with dilantin-induced lymphocyte transformation in vitro.

A patient with a classical salivary gland benign lymphoepithelial lesion (BLL) that converted to a lymphoblastic lymphoma (LSA) localized to the salivary glands is described. The malignant transformation of the BLL was preceded by Dilantin anticonvulsant therapy, and in vitro tests subsequent to the development of LSA demonstrated positive Dilantin-induced lymphocyte transformation. The lymphoma was treated successfully by local irradiation, chemotherapy, and discontinuation of Dilantin. The case illustrates the "prelymphomatous" nature of BLL in certain patients, as well as the possible potential danger of Dilantin and other lymphoid-stimulating drugs in discussed. Further study of drugs capable lymphocyte transformation in patients with prelymphomatous disorders is warranted.

Cell Transformation, Neoplastic↗
PubMed1975

Hemoperitoneum from liver cell adenoma in a patient on oral contraceptives.

A case of hemoperitoneum from ruptured benign liver cell adenoma in a young woman with a long history of oral contraceptive use is presented. The importance of recognizing the cause of this intra-abdominal emergency is stressed, and comment is made about the entity occurring in women on contraceptive drugs.

Adult↗
PubMedDate not supplied

Branchio-oto-renal dysplasia associated with tetralogy of Fallot.

Branchio-oto-renal dysplasia in its full expression consists of external ear malformations, cervical fistulas or cysts, preauricular pits, hearing loss of conductive sensorineural or mixed type, and renal anomalies. The syndrome is inherited in an autosomal dominant mode. We present a sporadic case of BOR dysplasia associated with tetralogy of Fallot in a 30-month-old girl. The clinical aspects of the disease are discussed briefly.

Branchial Region↗
PubMedDate not supplied

Agenesis of sphenoid sinus. Case report.

Although the sphenoid sinuses can be identified in sections of the fetus at 4 months, at birth the sinus remains small and is little more than an evagination of the sphenoethmoid recess. After the 3rd year, invasion of the sphenoid bone is more rapid, and by the age of 7, the sinus has extended posteriorly to the level of the sella turcica. By the age of 12, the sphenoid pneumatization reaches its final form and a size equivalent to the adult, although further enlargement into the basisphenoid may occur in the adult. Agenesis of paranasal sinuses is an uncommon clinical sign and refers mainly to the frontal and secondarily to the maxillary sinuses. Agenesis of sphenoid sinuses is a very rare phenomenon in the literature. We present a 32-year-old male patient with agenesis of sphenoid sinuses that was studied by CT.

Adult↗
PubMedDate not supplied

Early extraction of the mandibular third molar in case of eruption disturbances of the second molar.

PURPOSE: General consensus has been reached on extracting mandibular third molars when they are involved in pathologic processes. However, early extraction is advisable in cases of eruption disturbances of the mandibular second molar, before or during orthodontic treatment. METHODS: Thirty-two patients with early extraction of the mandibular third molar before or during orthodontic treatment were examined. RESULTS: In these cases either the presence of the third molar presented an obstacle in the eruption path of the second, or third molar germ removal was considered beneficial to the course of orthodontic treatment. CONCLUSIONS: Early extraction of the mandibular third molar facilitates the eruption of the second molar, especially in cases where evidence of crowding and lack of space in the posterior mandibular region exist. Orthodontic treatment may, in some cases, aggravate eruption disturbances of the second molar.

Adolescent↗