Bacillary angiomatosis of the skin and bone marrow in a patient with HIV infection.
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Adult↗
Biomedical subjects
K Anthony
Publications and source records attributed to K Anthony.
An analysis of the relationship of gender and age to MMPI scores of patients with chronic pain.
This study investigated the relationship of age and gender to the MMPI scores of patients with chronic pain; 1,766 patients with musculoskeletal lumbar and/or cervical pain were evaluated, using the MMPI. Multivariate analysis of variance (p < .001) revealed main effects for gender and age group variables; no interaction effects were found. For the age group variable, significant differences were found on two validity and seven clinical scales. Subjects in the 70- to 90-year age group produced the lowest scores on all scales except L, F, and MF. Linear declines across age groups, and quadratic effects were found on some scales. The authors hypothesize that developmental transitions may account in part for these findings.
Adaptation, Psychological↗
Mood and behaviour problems following the relocation of elderly patients with mental illness.
A prospective case-controlled study was carried out to evaluate the effect of an enforced move of elderly dementia sufferers from a large psychiatric hospital to smaller units in two general district hospitals. Changes in behaviour and nursing dependency, and mortality rate were used as outcome variables. The main finding was that a large proportion of the sample showed significant depressive behaviour following transfer. A significant degree of disturbed behaviour and disorientation remained 3 months after the move. There was some increase in the mortality rate of the group transferred relative to a comparison group but this did not reach statistical significance.
Affect↗
Abnormal development of genetically normal fetal hematopoietic stem cells in steel mutant mouse fetuses.
The role and possible transplantability of the early hematopoietic microenvironment was investigated by transplacental inoculation of fetal liver cells from normal donors into steel mutant early fetuses. Donor hematopoietic stem cells were able to lodge in the livers of recipients and to progress to the bone marrow postnatally. However, self-renewal of stem cells and production of differentiated blood cells was very limited in extent and duration after transplantation into mildly anemic steel as compared with Wv/+ heterozygotes. The microenvironmental defect known to exist (albeit undefined) in steel and not in W mutants thus adversely affects proliferation and differentiation of stem cells from the very inception of hepatic hematopoiesis and is not correctable by introducing normal stromal cells under the conditions of the experiment.
Anemia, Macrocytic↗
Monoclonal derivation of mouse myeloid and lymphoid lineages from totipotent hematopoietic stem cells experimentally engrafted in fetal hosts.
Mutant mouse fetuses with a hematopoietic stem cell defect were injected with a mixture of two normal strains of fetal liver cells to test the possibility of seeding with single stem cells and of deriving all hematopoietic lineages clonally. Recipients were either Wf/Wf, with a mild endogenous defect offering only marginal selective advantage to a normal donor cell, or W/W, with a severe defect. Among 11 Wf/Wf animals with long-term grafts, 8 had only one or the other of the donor strains. Some of these individuals must have been seeded by only a single donor cell (P = 0.1); the frequency of this event was at least 20% (90% confidence) and most likely 50% of the cases. Cell-specific strain markers in myeloid and lymphoid lineages reinforced the likelihood that renewal and differentiation had occurred from a totipotent hematopoietic stem cell. In a smaller W/W group, some hosts were seeded by at most two cells (P = 0.1), and single-cell seeding could not be ruled out. The experiment allows stem cell pedigrees to be examined during the normal developmental progression. In both groups observed here, some mice displayed a regular and complementary rise and fall in proportions of cells of different genotypes, thereby suggesting clonal succession in a hierarchy of stem cell compartments. This transplant system also offers advantages for future experiments on regulated expression in vivo of genes transferred (in vitro) into totipotent hematopoietic stem cells.
Animals↗