On the mechanism of the anti-androgenic effect of medroxyprogesterone acetate.
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Animals↗
Biomedical subjects
K Altman
Publications and source records attributed to K Altman.
Hydrocortisone induction of rat-liver leucyl-transfer RNA and its synthetases.
Within 3 hr after the intraperitoneal administration of hydrocortisone to female rats, a new leucine-accepting tRNA and a new leucyl-tRNA synthetase activity appear in the liver cytosol. The new isoaccepting tRNA can be acylated only with the synthetase derived from livers of hormone-treated animals. Both components are transient; by 12 hr after hydrocortisone administration, the isoaccepting tRNA and its synthetase disappear from livers of treated animals.
Amino Acyl-tRNA Synthetases↗
Induction of hepatic testosterone A-ring reductase by medroxyprogesterone acetate.
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17-Ketosteroids↗
Human hepatic testosterone A-ring reductase activity: effect of medroxyprogesterone acetate.
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Adult↗
The effect of x-irradiation on collagen metabolism in polyvinyl-sponge granulomas.
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Animals↗
Effect of medroxyprogesterone acetate (Provera) on the metabolism and biological activity of testosterone.
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Adult↗
Lack of inhibition by 6-beta-hydroxycortisol and o,p'-DDD on the cortisol mediated induction of rat hepatic tryptophan oxygenase: the corticoid effect of 6-alpha-hydroxycortisol.
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Animals↗
Tryptophan pyrrolase induced in human liver by hydrocortisone: effect on excretion of kynurenine.
Administration of hydrocortisone causes two- to fourfold increase in the level of activity of tryptophan pyrrolase in human liver, as measured in needle-biopsy specimens. Correlation of the higher levels of the enzyme with the amounts of urinary kynurenine suggests that the tryptophan pyrrolase level, which is regulated by adrenocortical hormones, may be the important variable in the increased excretion of tryptophan metabolites that accompanies various diseases.
Adult↗
Correlation of kynurenine excretion with liver tryptophan pyrrolase levels in disease and after hydrocortisone induction.
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Adolescent↗
Lidocaine in refractory status epilepticus: confirmation of efficacy with continuous EEG monitoring.
Lidocaine was efficacious in 2 patients with refractory status epilepticus (RSE) unresponsive to several antiepileptic drugs (AEDs), including high-dose barbiturates. We confirmed the efficacy of lidocaine with, for the first time in adults, continuous EEG monitoring. Lidocaine, when properly used, may be a treatment option in RSE.
Adult↗