[Pharmacogenetic reaction to succinyldicholine: therapy of prolonged apnea].
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Adult↗
Biomedical subjects
K Altland
Publications and source records attributed to K Altland.
Pseudocholinesterase-variants in Thailand and Japan.
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Cholinesterases↗
Transthyretin Leu 68 in a form of cardiac amyloidosis.
A form of transthyretin (TTR)-related cardiac amyloidosis was previously described in a German patient. Electrophoretic analysis of plasma TTR showed the presence of an electrically neutral variant. We have now characterized the variant transthyretin by comparative peptide mapping, aminoacid and DNA sequencing procedures. A new mutation in TTR with a substitution of leucine for isoleucine at position 68 of the monomer is described.
Amino Acid Sequence↗
[The apolipoprotein E gene and Alzheimer disease phenotype].
The relevance of the apolipoprotein E epsilon 4 allele as risk factor for Alzheimer's disease is independent of age. This was demonstrated in 126 patients and 72 healthy controls. The age in both groups varied between 44 and 95 years. An earlier onset of symptoms among carriers of the epsilon 4 allele, however, was observed only in the oldest patients. This may reflect a selection bias which is due to the association of the epsilon 4 allele with two competitive age-dependent risks: for Alzheimer's disease and for coronary heart disease. In a subsample of 64 patients who had participated in a longitudinal study no relationship was found between the apolipoprotein E genotype and clinical symptoms or symptom progression.
Adult↗