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Biomedical subjects

K Adams

Publications and source records attributed to K Adams.

At least 91 records · Page 5Linked to original sources
PubMed1981

Simultaneous bilateral radiation for advanced bilateral retinoblastoma.

A retrospective review of 1,424 cases of retinoblastoma disclosed 34 patients with advanced bilateral retinoblastoma whose sole initial treatment was simultaneous bilateral radiation. All patients had a combination of bilateral group IV or V retinoblastoma. Mean age at diagnosis was 13.1 months. Five-year survival of patients was 88% (28/32). In two (7%) of 28 surviving patients, a second nonocular tumor developed: one inside and one outside the field of radiation. Of the 64 eyes treated, 44 ultimately were enucleated. Of ten eyes requiring a second course of radiation, nine were enucleated. In only one eye was enucleation due to radiation complications. Eleven patients required additional treatment with light coagulation, cryopexy, or cobalt plaques.

Adolescent↗
PubMed1979

Normal neuropsychological abilities of alcoholic men in their late thirties.

The neuropsychological performance of alcoholic men in their late 30s (mean age, 37 years), some of whom has been abstinent for 3 weeks and others for 18 months, was compared with that of a group of men who drank occasionally. There were no differences between the alcoholic groups and the comparison group that could not be attributed to normal aging. The number of years of alcoholism or estimated lifetime alcohol use, dietary adequacy, and medical or blackout history did not relate to neuropsychological impairment. The authors suggest that a simple "dose-effect" relationship between alcohol use and cognitive decline cannot be assumed.

Adult↗
PubMed1979

Lung damage in C57B1 mice following thoracic irradiation: enhancement by chemotherapy.

C57Bl mice were treated with thoracic irradiation to doses in the range 12.0 to 18.9 gray. Few deaths were observed in the period 80--160 days after irradiation (an end-point of lung damage used by other investigators) and the median survival times ranged from 200 to 310 days. CBA mice treated under identical conditions predominantly died between 80--160 days and it is therefore concluded that C57Bl mice show unusually prolonged survival following this treatment. Six chemotherapeutic agents were given to C57Bl mice together with thoracic irradiation, in most cases two weeks beforehand. Adriamycin, bleomycin and cyclophosphamide enhanced the mortality of the mice. Most agents had little effect on radiation-induced skin damage.

Animals↗
PubMed1979

Bureau of Support Services.

Explore the source record for details and available documents.

Centers for Medicare and Medicaid Services, U.S.↗
PubMed1978

Computed tomography after psychosurgery.

The computed tomography scans of patients who had frontal leukotomy show bilateral cysts in the frontal lobes that have attenuation values similar to cerebrospinal fluid, and are not contrast enhanced.

Adult↗
PubMed1977

Influence of granulation liquid flow rate on particle-size distribution in spray-granulate products.

Granulations were made at various air speeds and various rates of addition of granulating liquid in a spray-granulatin assembly. The ensuring particle sizes were log-normal, and the data substantiate that the process is of the nature previously described. The mean diameter obtained was approximately proportional to the liquid flow rate squared but was independent of air rate. The standard deviation was independent of both parameters.

Drug Compounding↗
PubMed1977

Clonogenic assays in the B16 melanoma: response to cyclophosphamide.

The survival of clonogenic cells in the B16 melanoma has been studied simultaneously by 3 methods: an in vitro assay in soft agar, a lung-colony assay, and the end-point dilution technique. Details of the first 2 methods have previously been reported, but those of the third are described here. The 3 methods have agreed well in investigations of the response of the B16 melanoma to cyclophosphamide.

Cell Count↗
PubMed1977

Enhancement by cytotoxic agents of artificial pulmonary metastasis.

The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.

Animals↗