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Biomedical subjects

K Aabo

Publications and source records attributed to K Aabo.

42 records · Page 3Linked to original sources
PubMed1981

Distribution of intrapulmonary megakaryocytes.

The distribution of intrapulmonary megakaryocytes is equal in healthy persons, but altered in diseased persons, the highest counts being found in superior lobes (p = 0.0027). This may be explained by the altered blood supply to the lungs of diseased persons lying in bed. We recommend that lung sections should be taken from central areas of the superior lobes in order to standardize the sections and to compare results of future investigations on intrapulmonary megakaryocytes.

Cell Count↗
PubMed1980

Feminization in hepatocellular carcinoma corrected by chemotherapy: a case report.

A 17-year-old boy with metastatic hepatocellular carcinoma and feminization became asymptomatic after administration of antineoplastic agents. Serum estradiol level, urine estrogens, and tumor estrogen receptors were changed after the treatment. Achievement of partial remission resulted in normalization of the serum sex hormone profile and disappearance of the feminization in spite of the presence of residual tumor. Thus, serum hormone levels alone cannot be used as tumor markers for control of therapy. This suggests that chemotherapy may have altered the biological behavior of the tumor, which resulted in loss of its ability to synthesize estrogen estrogen receptors.

Adolescent↗
PubMed1979

Response of pulmonary (circulating) megakaryocytes to experimentally induced consumption coagulopathy in rabbits.

The effects of slow temporary infusion of a tissue thromboplastin solution into the superior vena cava on pulmonary as well as circulating megakaryocytes were studied in 40 rabbits (2-48 hours after infusion) and related to 6 noninfused and 7 infused with normal saline. This is a simple and specific method of inducing a fall in blood platelet levels and thereby an activation of thrombocytopoiesis and megakaryocytopoiesis. The induced intravascular coagulation is probably counterbalanced by an activated fibrinolysis allowing the animals to survive the infusion and thereby offering the possibility of studying the long-term effects. An increase to about 300% of the normal values in circulating as well as pulmonary megakaryocytes was found 20 and 24 hours after the onset of the infusions respectively. The number of circulating and pulmonary megakaryocytes, showing great individual variations, however, dropped to normal levels within 28 hours after onset of the infusions, which means that megakaryocytes remain detectable for less than eight hours in the lungs. No increase was found in pulmonary megakaryocytes in the control (saline infused) group. In our opinion the entrance of megakaryocytes from the bone marrow into the blood circulation in an incidental event, the number in the circulation reflecting the activity of megakarycocytopoiesis. This experiment supports our suggestion that intravascular coagulation is one of the major pathophysiological mechanisms leading to an increase in pulmonary megakaryocytes.

Animals↗
PubMed1979

New aspects of the morphology of circulating megakaryocytes in rabbits.

Circulating cytoplasmatic megakaryocytes, isolated from central venous blood of rabbits by a saponinhaemolysis leuco-concentration technique, were found to have two morphological appearances: a globular and an oblong form, referring to the shape of the cells as a whole as well as to the shape of the nuclei. The nucleus was either centrally or peripherally located. Of the megakaryocytes observed, 40% were cytoplasmatic and 60% naked nuclei. Regressive changes in the residual nucleus was observed, only 1.5% showing karyorrhexis or karyolysis. Megakaryoblasts and promegakaryocytes were never encountered. The average megakarycyte content per ml central venous blood was 3.8 (range: 0-10). A not previously described cytoplasmatic-ligating process, in which the nucleus seemed to move out of the cytoplasm, forming a naked nucleus and leaving the total cytoplasm intact, was observed. We call this phenomenon "nucleus escape". The function and fate of the intravascular megakaryocytes are briefly discussed.

Animals↗
PubMed1978

Megakaryocytes in pulmonary blood vessels. 2. Relations to malignant haematological diseases especially leukaemia.

In a study of 71 autopsies in patients with malignant haematological disorders (55 leukaemias and 16 multiple myelomas) we found an increased number of megakaryocytes in the lung capillaries in only one of 55 cases of leukaemia (43 acute and 12 chronic leukaemias) with a mean value of 3 megakaryocytes per cm2. The incidence of pulmonary megakaryocytes in 16 cases of multiple myeloma was identical to that in an unselected, consecutive series of hospital autopsies. The discrepancy between the increased megakaryocytopoiesis and previously reported high number of circulating megakaryocytes in chronic myeloid leukaemia, and the few megakaryocytes in the pulmonary blood vessels of histological sections of autopsy specimens is discussed.

Acute Disease↗