Biomedical subjects
Publications and source records attributed to K A Margolius.
We report a case of acute rhabdomyolysis following the abuse of opiates injected intravenously. The patient also developed mild renal failure as well as transient myocarditis. The pathogenesis and management of the condition are discussed.
Two cases of granuloma inguinale detected cytologically on routine Papanicolaou-stained cervical smears are presented; the cytologic and histologic features are described in detail, and the electron microscopic appearances are shown. The suitability of the Papanicolaou stain in the detection of granuloma inguinale is discussed, with emphasis on possible differential diagnoses to be considered. It is concluded that a definitive diagnosis of granuloma inguinale can be made on routine Papanicolaou-stained smears showing the following spectrum of changes: intact capillaries indicative of epithelial and stromal ulceration; a marked inflammatory cell infiltrate consisting predominantly of neutrophils; epithelioid histiocytes representing granuloma formation; and Donovan bodies located in characteristic single or multiple intracytoplasmic vacuoles within large histiocytes. Recognition of this cytologic picture may enable early diagnosis, even in nonendemic areas, of a potentially disfiguring venereal disease.
OBJECTIVE: To present a review of the circumstances of 64 cycling fatalities in Western Australia (WA) during the nine-year period 1984-1992, and the major injuries sustained by the cyclists. DATA SOURCES: The number of deaths was ascertained from lists maintained by the WA Police Department, Forensic Pathology Division of the Health Department and the Coroner's office. Individual case files held by the Coroner's office and Forensic Pathology Division were then examined for details of the circumstances of each incident, epidemiological data, and medical and toxicological findings. DATA SYNTHESIS: Most of the 64 fatalities (59%) occurred in children or young adults less than 20 years of age. Most fatal injuries (54%) were to the head alone. Forty-seven of the deaths involved collision with a motor car. Alcohol was demonstrated in the blood of five of the 30 cases in which analysis of blood alcohol level was performed. On average, 7.8 cyclists died annually in WA before the introduction of legislation for the compulsory wearing of safety helmets while cycling. In the 12-month period following this legislation, there was only one cycling death. CONCLUSIONS: Most cycling deaths occur in children, primarily from head injury resulting from impact with a motor car. The enactment of legislation for the compulsory wearing of cycling helmets has been associated with a fall in cyclist fatalities.
The cytologic picture seen in two cases of rectovaginal endometriosis diagnosed by fine needle aspiration (FNA) cytology is presented in detail. The cell pattern differed considerably from that previously described in fluid specimens and more closely resembled the exfoliation observed in direct endometrial samples. No previous report appears to exist on the diagnosis of rectovaginal endometriosis by FNA.