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Documentation↗
Biomedical subjects
K A Lyon
Publications and source records attributed to K A Lyon.
Ration digestibilities and ruminal characteristics in steers fed chickpeas.
Twenty-four Holstein steers were used in a 5-d digestion trial to evaluate chickpeas as a substitute for corn and soybean meal. Total mixed diets contained (dry basis) 51% concentrate mix, 33% corn silage, and 16% alfalfa hay. Concentrate mixes contained 0, 50, and 100% chickpeas in place of corn and soybean meal. Ad libitum intakes of DM were not different between diets. Digestibilities of DM, NDF, ADF, hemicellulose, cellulose, lignin, and gross energy were not different among diets. Digestibilities of protein, fat, and ash were greater for steers fed 100% chickpeas than 0% chickpeas. Fecal N was lower and absorbed N was higher for steers fed 100% chickpeas. Ruminal acetate and acetate:propionate ratio were lower and ruminal propionate was higher for all steers fed diets containing chickpeas. Ruminal ammonia and pH were similar for all treatments.
Animal Feed↗
Assay methodology for quantification of the ester and ether glucuronide conjugates of diflunisal in human urine.
Diflunisal is a salicylate derivative with analgesic and anti-inflammatory properties. It is excreted in the urine as an ether glucuronide, a 1-O-acyl glucuronide and as unchanged drug. The 1-O-acyl glucuronide rearranges to isomeric esters of glucuronic acid under neutral to alkaline pH conditions. The development of a urine assay for the conjugates enables the elucidation of diflunisal non-linear pharmacokinetics. The assay quantitates the ether and ester glucuronides and free diflunisal in urine at 0.5-1.0 micrograms/ml. Analysis of the glucuronides does not require authentic standards.
Chromatography, High Pressure Liquid↗