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Biomedical subjects

K A Frank

Publications and source records attributed to K A Frank.

20 records · Page 2Linked to original sources
PubMedDate not supplied

Type A behavior and blood pressure during general surgery.

The Type A behavior pattern (TABP) has been demonstrated as a risk factor for the development of coronary heart disease (CHD). Psychophysiologic studies suggest that the TABP may be associated with autonomic hyperreactivity to a variety of stressors. Recent studies report an association of TABP with autonomic hyperreactivity in patients under general anesthesia for coronary artery bypass surgery. The present study did not find a significant correlation between the TABP and intraoperative rise in blood pressure for 44 noncardiac patients undergoing anesthesia for elective general surgical procedures. Suggestive associations were found in sub-samples with family history of CHD or age greater than 60 years. Thus, the TABP may be correlated with heightened physiologic response under anesthesia only in selected populations.

Adult↗
PubMedDate not supplied

Psychologic treatment for the type A behavior pattern and for coronary heart disease: a meta-analysis of the literature.

The Type A behavior pattern (TABP) is a recognized risk factor for coronary heart disease (CHD), and yet treatments aimed at its modification are not in widespread use. We reviewed the literature of controlled studies (N = 18) of the psychologic treatment of the TABP and of CHD with the statistical method of "meta-analysis." The results of each study were converted to a standardized "Effect Size" (ES). The mean ES for TABP measures was 0.61 +/- 0.20 (95% confidence interval) (p less than 0.001), indicating that after treatment subjects across all studies reduced their TABP scores by half a standard deviation. The combined significance probability (pc) across studies for reduction in 3-year combined mortality and myocardial infarction was pc less than 0.0001, corresponding to a reduction in coronary events of roughly 50% after psychologic treatment. This finding must be approached with caution because it is based on only two studies. The analysis suggested that a combination of treatment techniques is most effective in reducing TABP and CHD recurrences. The literature was critiqued, and limitations of the findings are discussed. We conclude that psychologic intervention to reduce TABP may improve clinical outcome of CHD and that this deserves further study and preliminary clinical application.

Adult↗