Biomedical subjects

Julie C Kiefer

Publications and source records attributed to Julie C Kiefer.

7 recordsLinked to original sources

PubMed2006

microRNAs under the microscope.

Once regarded as a biological anomaly, microRNAs (miRNAs) have since been recognized as a prevalent RNA species that regulates a wide array of biological processes, from fat storage and insulin secretion, to apoptosis and cell growth. Recent studies show that miRNAs are expressed at precise times and locations in embryonic development. Moreover, disruption of miRNA processing triggers widespread developmental defects. These findings bolster the idea that miRNAs also regulate multiple aspects of embryonic development. This primer focuses on the emerging roles of miRNAs in development. The basics of miRNA biogenesis and miRNA and mRNA target identification are covered, with an emphasis on miRNA function in development. The primer also features a dialog about current topics in the field.

Animals↗

PubMed2006

Emerging developmental model systems.

This primer briefly describes four emerging animal model systems that promise to provide insights into specific aspects of developmental biology. Highlighted here are two relatively well-characterized model systems, Gasterosteus aculeatus (three-spine stickleback fish) and Schmidtea mediterranea (planarian), as well as two organisms on which research is in its infancy, Carollia perspicillata (short-tailed fruit bat), and the basal metazoan, Trichoplax adhaerens. Scientists who helped develop these species into model systems discuss why they chose to research these animals.

Animals↗

PubMed2005

The somite segmentation clock: it takes a licking and keeps on ticking.

This primer describes molecular mechanisms critical for somite segmentation clock function. In addition, two investigators of the segmentation clock, Olivier Pourquie, and Yun-Jin Jiang, give their perspectives on current research and on the future of the field.

Animals↗

PubMed2005

Planar cell polarity: heading in the right direction.

Epithelial cells are patterned not only along their apical-basolateral axis, but also along the plane of the epithelial sheet; the latter event is regulated by the planar cell polarity (PCP) pathway. PCP regulates diverse outputs, such as the distal placement of a hair in all cells of the Drosophila wing, and convergent extension movements during gastrulation in the vertebrate embryo. This primer describes the molecular mechanisms that initiate and establish PCP, as well as biochemical pathways that translate PCP signaling to cell type-specific patterning events. The primer concludes with a discussion of current topics in the field with two PCP researchers, Matt Kelley, Ph.D., and Helen McNeill, Ph.D.

Animals↗

PubMed2005

Pro-neural factors and neurogenesis.

The role of pro-neural factors in specifying neuronal progenitors and in promoting neuronal differentiation is conserved from Drosophila to vertebrates. This primer discusses the basic functions of pro-neural factors in neurogenesis, mechanisms of pro-neural factor function, and models for how pro-neural factors generate neuronal subtypes. The primer also features a dialog about current topics and future directions in the field between two experts in neurogenesis: Andrew Jarman, Ph.D., and Jane Johnson, Ph.D.

Animals↗

PubMed2004

The Tbx-files: the truth is out there.

T-box factors are critical regulators of embryonic development and have been implicated in several human diseases. This primer describes the basics of how T-box factors work and features a discussion of the state of T-box gene research with three experts in the field.

Animals↗

PubMed2003

Molecular mechanisms of early gut organogenesis: a primer on development of the digestive tract.

Creating an organ poses unique challenges in embryogenesis, including establishing an organ primordium and coordinating development of different tissues in the organ. The digestive tract (gut) is a complex organ system, posing the interesting question of how the development of a series of organs is coordinated to establish an organ system with a common function. Although gut development has been the focus of much research, the molecular mechanisms that regulate these events are just beginning to be understood. This primer will first outline the basic anatomy of the digestive tract and then focus on molecular mechanisms that drive vertebrate gut organogenesis. Deciphering mechanisms underlying gut organogenesis also provides insights into understanding the development of other organs.

Animals↗