Biomedical subjects

Juan-Ignacio Alós

Publications and source records attributed to Juan-Ignacio Alós.

3 recordsLinked to original sources

PubMed2004

Evaluation of Granada agar plate for detection of Streptococcus agalactiae in urine specimens from pregnant women.

The Granada agar plate (GAP; Biomedics SL, Madrid, Spain) was evaluated for the detection of group B streptococci (GBS) in urine specimens from pregnant women submitted for testing for asymptomatic bacteriuria and was compared with blood agar (BA [Columbia agar with 5% sheep blood]; bioMérieux, Marcy l'Etoile, France). The GAP detected 103 out of 105 GBS, whereas BA detected only 50. Use of the GAP could be a good method for the detection of GBS in urine specimens from pregnant women.

Agar↗

PubMed2003

[Quinolones].

Quinolones act by inhibiting enzymes (topoisomerases), which are indispensable to DNA synthesis. Their bactericidal activity is concentration-dependent. Their spectrum has become broader, especially since the introduction of a fluorine atom at position 6 (fluoroquinolones). They are used as the treatment of choice or as alternative therapy in a wide variety of infections, both in the hospital and non-hospital setting. Depending on the compound, they are used in urinary tract infections, sexually transmitted diseases, chronic osteomyelitis, respiratory tract infections, and severe systemic infections, among others. The upsurge and extent of quinolone resistance has limited the use of these agents in some cases and in future may determine their use in others. There are strategies to minimize the spread of resistance. Quinolones are safe and well tolerated. The most frequent adverse effects are gastrointestinal and those affecting the central nervous system.

4-Quinolones↗

PubMed2002

Increase in resistance to new fluoroquinolones from 1998 to 2001 in the Bacteroides fragilis group.

Susceptibility to anti-anaerobic agents in the Bacteroides fragilis group varies according to the geographical region studied. In recent years there has been a reduction in the susceptibility of such isolates, especially to certain antibiotics such as clindamycin and cefoxitin. The antimicrobial susceptibilities of 200 strains of the B. fragilis group isolated in 1998 (100) and 2001 (100) from faecal samples of healthy people to anti-anaerobic agents were determined. Meropenem, metronidazole and chloramphenicol showed excellent activity against all isolates. The efficacy of cefoxitin was low, with only 43% of strains isolated in 2001 showing susceptibility. A high prevalence of resistance to clindamycin, reaching 56% of recent isolates, was observed. A significant increase in resistance to new fluoroquinolones, from 0% in 1998 to 12% in 2001, was detected.

Anti-Infective Agents↗