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Biomedical subjects

Jovan G Brankov

Publications and source records attributed to Jovan G Brankov.

2 recordsLinked to original sources

Tomographic image reconstruction based on a content-adaptive mesh model.

In this paper, we explore the use of a content-adaptive mesh model (CAMM) for tomographic image reconstruction. In the proposed framework, the image to be reconstructed is first represented by a mesh model, an efficient image description based on nonuniform sampling. In the CAMM, image samples (represented as mesh nodes) are placed most densely in image regions having fine detail. Tomographic image reconstruction in the mesh domain is performed by maximum-likelihood (ML) or maximum a posteriori (MAP) estimation of the nodal values from the measured data. A CAMM greatly reduces the number of unknown parameters to be determined, leading to improved image quality and reduced computation time. We demonstrated the method in our experiments using simulated gated single photon emission computed tomography (SPECT) cardiac-perfusion images. A channelized Hotelling observer (CHO) was used to evaluate the detectability of perfusion defects in the reconstructed images, a task-based measure of image quality. A minimum description length (MDL) criterion was also used to evaluate the effect of the representation size. In our application, both MDL and CHO suggested that the optimal number of mesh nodes is roughly five to seven times smaller than the number of projection bins. When compared to several commonly used methods for image reconstruction, the proposed approach achieved the best performance, in terms of defect detection and computation time. The research described in this paper establishes a foundation for future development of a (four-dimensional) space-time reconstruction framework for image sequences in which a built-in deformable mesh model is used to track the image motion.

Algorithms↗

Multiple-image radiography.

Conventional radiography produces a single image of an object by measuring the attenuation of an x-ray beam passing through it. When imaging weakly absorbing tissues, x-ray attenuation may be a suboptimal signature of disease-related information. In this paper we describe a new phase-sensitive imaging method, called multiple-image radiography (MIR), which is an improvement on a prior technique called diffraction-enhanced imaging (DEI). This paper elaborates on our initial presentation of the idea in Wernick et al (2002 Proc. Int. Symp. Biomed. Imaging pp 129-32). MIR simultaneously produces several images from a set of measurements made with a single x-ray beam. Specifically, MIR yields three images depicting separately the effects of refraction, ultra-small-angle scatter and attenuation by the object. All three images have good contrast, in part because they are virtually immune from degradation due to scatter at higher angles. MIR also yields a very comprehensive object description, consisting of the angular intensity spectrum of a transmitted x-ray beam at every image pixel, within a narrow angular range. Our experiments are based on data acquired using a synchrotron light source; however, in preparation for more practical implementations using conventional x-ray sources, we develop and evaluate algorithms designed for Poisson noise, which is characteristic of photon-limited imaging. The results suggest that MIR is capable of operating at low photon count levels, therefore the method shows promise for use with conventional x-ray sources. The results also show that, in addition to producing new types of object descriptions, MIR produces substantially more accurate images than its predecessor, DEI. MIR results are shown in the form of planar images of a phantom and a biological specimen. A preliminary demonstration of the use of MIR for computed tomography is also presented.

Absorptiometry, Photon↗