Biomedical subjects

Josep Brugada

Publications and source records attributed to Josep Brugada.

60 records · Page 4Linked to original sources

PubMed2002

Fever unmasking the Brugada syndrome.

This case report describes a 66-year-old woman with severe polymorphic ventricular tachycardia and syncope during a febrile state. The electrocardiogram revealed a right bundle branch block and pattern of elevated ST segment in the anterior and inferior leads similar to the Brugada syndrome. These electrocardiographic anomalies disappeared when the temperature returned to normal. The administration of procainamide reproduced the electrocardiographic changes. An electrophysiological study using two extrastimuli induced ventricular tachycardia. An automatic defibrillator was implanted.

Aged↗

PubMed2002

Radiofrequency catheter ablation of an incessant supraventricular tachycardia in a premature neonate.

A 32-week, premature neonate with incessant supraventricular tachycardia and hemodynamic compromise who failed to respond to antenatal and postnatal antiarrhythmic therapy underwent successful radiofrequency catheter ablation (RCA) of a concealed left free-wall accessory pathway when the infant was 4-days-old and weighed only 1,840 grams. At follow-up performed 60 days after the procedure, the infant remained free of any drug, in sinus rhythm, and in normal hemodynamic condition.

Adult↗

PubMed2002

Accessory pathway localization by QRS polarity in children with Wolff-Parkinson-White syndrome.

INTRODUCTIONS: Location of the accessory pathway (AP) in Wolff-Parkinson-White (WPW) syndrome can be determined accurately by the QRS polarity on resting ECG. These ECG characteristics may be different in children, and no algorithm has yet been tested. METHODS AND RESULTS: A total of 153 resting ECGs of symptomatic children with WPW syndrome were retrospectively analyzed. The anatomic AP location had been established fluoroscopically at eight possible sites during radiofrequency catheter ablation. Two independent observers predicted AP location on blinded ECGs with a QRS polarity algorithm for adults using leads II, III, aVL, V1, and V2. Subsequently, the QRS polarity for all individual ECG leads was evaluated and a new algorithm for children was devised. With the adult algorithm, the observers correctly predicted only 55% to 58% of AP locations. The septal and right-sided pathways often were inseparable, and mid-septal and parahisian pathways were missed. In the new children's algorithm, left lateral, left posteroseptal, and posteroseptal pathways shared a positive or intermediate QRS polarity on V1, with the left lateral pathway separated by a positive QRS polarity on lead III. Negative QRS polarity on lead V1 and positive QRS polarity on lead V3 were shared by right posteroseptal, mid-septal, parahisian, and anteroseptal pathways, with the latter two having a positive QRS polarity on lead aVF. Right lateral pathways had negative QRS polarity on lead V1 and negative or intermediate QRS polarity on lead V3. Overall accuracy for these five regions was 90%. CONCLUSION: AP characterization by QRS polarity in children with WPW syndrome is more diverse than in adults and requires other ECG leads to establish five AP regions.

Adolescent↗

PubMed2002

Relevance of atrial fibrillation classification in clinical practice.

Use of different classifications for atrial fibrillation reflects the complexity of the arrhythmia and the difficulty in grouping its different aspects. Current classifications are based on clinical presentation, etiology, substrates, mechanisms, etc. From the clinical point of view, the most relevant probably should be one directed at classifying patients in terms of therapeutic options. In this article, a review of known classifications is given, together with an attempt at a new classification based on the possibility of offering a nonpharmacologic treatment to patients.

Anti-Arrhythmia Agents↗

PubMedDate not supplied

[Radiofrequency ablation of late ventricular tachycardia in patients with corrected Tetralogy of Fallot].

We present the cases of two patients with surgical repaired Tetralogy of Fallot and late ventricular tachycardia. In one patient, the ventricular tachycardia had a right bundle branch block pattern, and in the other, a left bundle branch block pattern. In both patients a macroreentrant circuit in the right ventricular outflow tract was documented; radiofrequency ablation was effective in both cases. This suggests that the morphology of the ventricular tachycardia in these patients could depend of the direction of the circuit into the right ventricular outflow tract and that mapping of this zone allows to localize the appropriate site for effective ablation.

Adult↗

PubMedDate not supplied

[Current concepts on sudden death].

Sudden death is defined as the death occurring less than one hour before the onset of the patient's symptoms. It is a severe condition considered a public health issue in several countries and in ours, it accounts for 33 000 to 53 000 annual deaths mainly related to ischemic heart disease. The main cause of sudden death are severe ventricular arrhythmias, but determining what patients are at risk for such an episode is complex, that is why risk stratification is usually a low cost-effective intervention. In the present study, we describe different sudden death risk-stratification strategies. Different sudden death treatment strategies regarding general population have different success rates in different countries, nevertheless, among select high risk populations; the best therapy currently available is the automatic implantable cardioverter-defibrillator. We also discuss other treatment options. In Mexico it is deemed necessary to do an important effort for the early detection, prevention and treatment of sudden death in order to limit the consequences of this problem.

Clinical Trials as Topic↗