Ocular adverse effects associated with cyclooxygenase-2 inhibitors.
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Adult↗
Biomedical subjects
Jonathan Solomon
Publications and source records attributed to Jonathan Solomon.
Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion.
We describe unusual ergosterol- and ceramide-rich (ECR) domains in the membrane of yeast peroxisomes. Several key features of these detergent-resistant domains, including the nature of their sphingolipid constituent and its unusual distribution across the membrane bilayer, clearly distinguish them from well characterized detergent-insoluble lipid rafts in the plasma membrane. A distinct set of peroxisomal proteins, including two ATPases, Pex1p and Pex6p, as well as phosphoinositide- and GTP-binding proteins, transiently associates with the cytosolic face of ECR domains. All of these proteins are essential for the fusion of the immature peroxisomal vesicles P1 and P2, the earliest intermediates in a multistep pathway leading to the formation of mature, metabolically active peroxisomes. Peroxisome fusion depends on the lateral movement of Pex1p, Pex6p, and phosphatidylinositol-4,5-bisphosphate-binding proteins from ECR domains to a detergent-soluble portion of the membrane, followed by their release to the cytosol. Our data suggest a model for the multistep reorganization of the multicomponent peroxisome fusion machinery that transiently associates with ECR domains.
ATPases Associated with Diverse Cellular Activitie↗
Geometric superresolution by code division multiplexing.
In many highly resolved optical systems the resolution is limited not by the optics but by the CCD's nonzero pixel size. As a result, overall resolution is decreased. Here we propose a novel approach to enhancing resolution beyond the limit set by the CCD's pixels. This method does not involve additional mechanical elements, such as those used for microscans. In this scheme neither the CCD nor additional elements are moved. The geometric superresolving procedure is based on code-division multiplexing, with all its inherent benefits, such as relative noise immunity to single-tone interference. A setup is proposed for coherent and incoherent illumination, with slight modifications for the latter. A theoretical analysis of the setup is presented and compared with empirical results. This scheme is shown to enhance one-dimensional image resolution with the use of only a simple mask that doubles image resolution. This method can easily be expanded to two-dimensional images and to resolution-enhancement factors greater than 2.
Journal Article↗
Invariant pattern recognition by use of a spatial code division multiplexing approach.
Invariant pattern recognition can be achieved by use of harmonic decomposition, for example circular harmonics are used for rotation invariant recognition. A common problem with such methods is that often only a single term of the harmonic decomposition is used, and it does not contain a sufficient amount of the reference energy. Thus discrimination capability is limited, especially in the presence of noise or other disturbances. By using several terms of the harmonic decomposition together this problem can be solved; this can be achieved by the use of code division filter multiplexing. Several harmonic terms are encoded onto a single filter, and the signal is simultaneously correlated with all of them, hence producing enhanced discrimination capabilities. Here two methods are suggested for such encoding. The first involves multiplexing the filters in the Fourier plane, while the second involves multiplexing in the image plane.
Journal Article↗
Superresolution by use of code division multiplexing.
Traditional methods for superresolution have sacrificed field of view for resolution. These methods multiplexed different parts of signals' spectrum on different carriers, and thus managed to transfer a wider range of frequency, in a manner that is similar to frequency division multiplexing in classical communication. We propose code division multiplexing for such an application, which has been shown to have superior capabilities. To enable such mutiplexing we propose a unique setup that creates an incoherent cosine transform of the image. A theoretical analysis of the setup is obtained and later compared with the empirical results.
Journal Article↗
Filter multiplexing by use of spatial Code Division Multiple Access approach.
The increasing popularity of optical communication has also brought a demand for a broader bandwidth. The trend, naturally, was to implement methods from traditional electronic communication. One of the most effective traditional methods is Code Division Multiple Access. In this research, we suggest the use of this approach for spatial coding applied to images. The approach is to multiplex several filters into one plane while keeping their mutual orthogonality. It is shown that if the filters are limited by their bandwidth, the output of all the filters can be sampled in the original image resolution and fully recovered through an all-optical setup. The theoretical analysis of such a setup is verified in an experimental demonstration.
Journal Article↗
Ocular side-effects associated with imatinib mesylate (Gleevec).
This retrospective case series describes ocular side-effects associated with imatinib mesylate (Gleevec) and the clinical characteristics of these adverse reactions. A chart review of 104 patients on imatinib mesylate therapy from Oregon Health & Science University's Cancer Center were studied with regard to ocular side-effects. In addition, spontaneous reports from the Food and Drug Administration, the World Health Organization, and the National Registry of Drug-Induced Ocular Side-Effects databases were reviewed, including a Medline literature search. Seventy-three (70%) of the patients at OHSU developed periorbital edema and 19 patients (18%) developed epiphora after receiving imatinib mesylate. Average dose was 407.5+/-60 mg. Periorbital edema occurred an average of 68+/-48 days after initiation of therapy. WHO classification of side-effects is as follows: certain: periorbital edema; probable: epiphora; possible: extraocular muscle palsy, ptosis, blepharoconjunctivitis; unlikely: glaucoma, papilledema, retinal hemorrhage, photosensitivity, abnormal vision, and increased intraocular pressure. Periorbital edema and epiphora are the two most common ocular side-effects related to imatinib mesylate therapy. Clinical characteristics of imatinib mesylate induced periorbital edema are described. Management of ocular side-effects is conservative except in very rare cases of visually significant periorbital edema.
Adult↗
Isolation and characterization of mutants of the Bacillus subtilis oligopeptide permease with altered specificity of oligopeptide transport.
Bacterial oligopeptide permeases are members of the large family of ATP binding cassette transporters and typically import peptides of 3 to 5 amino acids, apparently independently of sequence. Oligopeptide permeases are needed for bacteria to utilize peptides as nutrient sources and are sometimes involved in signal transduction pathways. The Bacillus subtilis oligopeptide permease stimulates competence development and the initiation of sporulation, at least in part, by importing specific signaling peptides. We isolated rare, partly functional mutations in B. subtilis opp. The mutants were resistant to a toxic tripeptide but still retained the ability to sporulate and/or become competent. The mutations, mostly in the oligopeptide binding protein located on the cell surface, affected residues whose alteration appears to change the specificity of oligopeptide transport.
ATP-Binding Cassette Transporters↗