Clinical inquiries. Is sputum evaluation useful for patients with community-acquired pneumonia?
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Community-Acquired Infections↗
Biomedical subjects
Jon Neher
Publications and source records attributed to Jon Neher.
Clinical inquiries. Does furosemide decrease morbidity or mortality for patients with diastolic or systolic dysfunction?
No large-scale randomized, placebo-controlled trials evaluate furosemide's effect on mortality and long-term morbidity in diastolic or systolic dysfunction. In short-term studies, furosemide reduces edema, reduces hospitalizations, and improves exercise capacity in the setting of systolic dysfunction (strength of recommendation [SOR]: B, based upon low-quality randomized controlled trials). Furosemide and other diuretics reduce symptomatic volume overload in diastolic and systolic dysfunction (SOR: C, based on expert opinion). There is potential morbidity with the use of high-dose loop diuretics (volume contraction, electrolyte disturbances, and neuroendocrine activation). Use of high-dose loop diuretics for systolic dysfunction is associated with increased mortality, sudden death, and pump failure death (SOR: B, based on retrospective analyses of large-scale randomized controlled trials). However, diuretic resistance or disease severity may explain these latter findings.
Diuretics↗
Clinical inquiries. Do imaging studies aid diagnosis of acute sinusitis?
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Anti-Bacterial Agents↗