Search PubMed⌕ Search

Biomedical subjects

John T Benjamin

Publications and source records attributed to John T Benjamin.

6 recordsLinked to original sources
PubMed2006

FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation.

Many extremely preterm infants continue to suffer from bronchopulmonary dysplasia, which results from abnormal saccular-stage lung development. Here, we show that fibroblast growth factor-10 (FGF-10) is required for saccular lung development and reduced in the lung tissue of infants with bronchopulmonary dysplasia. Although exposure to bacteria increases the risk of bronchopulmonary dysplasia, no molecular target has been identified connecting inflammatory stimuli and abnormal lung development. In an experimental mouse model of saccular lung development, activation of Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) inhibited FGF-10 expression, leading to abnormal saccular airway morphogenesis. In addition, Toll-mediated FGF-10 inhibition disrupted the normal positioning of myofibroblasts around saccular airways, similar to the mislocalization of myofibroblasts seen in patients with bronchopulmonary dysplasia. Reduced FGF-10 expression may therefore link the innate immune system and impaired lung development in bronchopulmonary dysplasia.

Animals↗
PubMed2006

Adult learning.

Explore the source record for details and available documents.

Adult↗
PubMed2005

The incidence, treatment, and follow-up of iron deficiency in a tertiary care pediatric clinic.

To assess the incidence, treatment, and follow-up of iron deficiency in children seen in a tertiary hospital, a retrospective chart review was performed in 2002 of 364 consecutive children screened for iron deficiency with free erythrocyte protoporphyrin and hemoglobin. Sixty-five of the 352 children studied (18.5%) were iron-deficient and 19 patients (5.4%) were anemic. Eighty percent of the affected children were treated with iron, and only 25% had follow-up blood testing done. Iron deficiency is common in children younger than 2 years of age. Whether or not the children had anemia, treatment and follow-up were less than optimal.

Adolescent↗
PubMed2003

Application of capture-recapture methodology to estimate the prevalence of dementia in South Carolina.

PURPOSE: The purpose of this study was to estimate the prevalence of dementia in individuals 65 years of age and older in the state of South Carolina using capture-recapture methodology. METHODS: We linked data from the Department of Mental Health admissions, inpatient admissions, and emergency room visits. Separate log-linear models were used to obtain estimates of the underascertainment-corrected prevalence of dementia in twelve age-gender-race subgroups, which were summed to estimate the prevalence of dementia in the total population. RESULTS: We found an overall prevalence of dementia of 14% in South Carolina for persons 65 years of age and older using capture-recapture methodology. This estimate of persons with dementia is 25% higher than the identified cases of dementia in the South Carolina Alzheimer's Disease Registry (10.5%). CONCLUSIONS: Although capture-recapture methods are prone to limitations, they can be used to more accurately estimate the prevalence of dementia in a geographic area.

Aged↗
PubMed2002

Can accurate immunization rates be determined in a primary care clinic?

Based on the data that we collected in our clinic, we were unable to determine the immunization rates of our patients accurately. Despite multiple telephone calls to families and health departments and an exhaustive chart review, 87 of the 261 families studied could not be contacted, thereby making an analysis of immunization data impossible. Another technique of tracking immunizations, such as a statewide or national registry, is needed to obtain accurate immunization data.

Child↗