Biomedical subjects
Publications and source records attributed to John P Hulme.
The replica molding and embossing of DNA texture has been achieved using a conventional polyurethane mold. The final process requires no additional or separate extraction phases. The polyurethane replica is stable up to 150 degrees C and possesses a good longevity and a capacity to emboss a biological entity into a thermosetting plastic such as poly(ethylene terephthalate).
This paper describes two fabrication procedures that makes it possible to design, fabricate and injection mold a microfluidic system with an on board coupling element or an optical array platform in less than four hours. Epoxy masters for the array and a single diffractive element were produced using conventional soft lithography techniques and a commercially available UV curable epoxy. The fabrication of the master for the integrated microfluidic device utilized the surface chemistry of polyester and its interaction with the anionic surfactant sodium dodecyl sulfate (SDS), to selectively inhibit the adhesion between the epoxy and the polyester film during the curing reaction. The transfer of a microfluidic design and the required coupling element (632 nm holographic grating) along the base of the channel was completed in a single step. The turnaround time from design to injection molded device whether a microchannel or array was 3.5 h.