Biomedical subjects

John M Pearce

Publications and source records attributed to John M Pearce.

10 recordsLinked to original sources

PubMed2003

Distinct patterns of hippocampal formation activity associated with different spatial tasks: a Fos imaging study in rats.

Fos levels were measured in rats trained in one of two qualitatively different spatial memory tasks in a water maze. In one task, ( landmark condition) rats found a submerged platform that was always 25 cm south of a visible landmark, the absolute position of the platform and landmark changing after every trial. In the other task ( place condition), rats swam to a platform that remained in the same absolute position on every session, but changed session to session, with this task relying on the memory of allocentric cues. Despite matched swim times, the landmark condition resulted in higher levels of Fos in a wide range of cortical and subcortical sites, including the hippocampus and its connections. Structural equation modelling revealed two different patterns of hippocampal function. In the allocentric place task there was a significant association between Fos activity in the entorhinal cortices and the hippocampus proper, while in the non-allocentric landmark task this relationship was not present, but was replaced by a connection from the entorhinal cortices to the subiculum. Thus, the two different tasks engage two different modes of hippocampal activity as demonstrated by Fos expression.

Animals↗

PubMed2003

Discrimination of structure: II. Feature binding.

In 3 experiments, pigeons acquired a discrimination between patterns comprising the same features. Thus vertical green bars beside horizontal red bars might have signaled food, and horizontal green bars beside vertical red bars might have signaled no food. The solution of this discrimination can be explained by assuming each pattern is represented either by a template or by structural features that are sensitive to combinations of color and line orientation. The 1st explanation predicts subjects should react to a training pattern rotated 90 degrees in the same way as the pattern on which it is based. The 2nd explanation predicts these patterns should be treated as if they signal opposing outcomes. The experiments confirmed the 2nd of these predictions.

Animals↗

PubMed2003

Visual search asymmetry in pigeons.

Pigeons received an odd-item search task that involved an array of 12 patterns containing 11 similar distractors and a single target. Pecks to the target resulted in the delivery of food. Accuracy was greater on trials when a distinctive feature was located in the target but not in the distractors, rather than when the feature was in the distractors but not in the target. This search asymmetry was influenced by the similarity of the target to the distractors. The results are similar to those obtained with humans.

Animals↗

PubMed2003

Facilitation of extinction by an increase or a decrease in trial duration.

Five experiments examined the effects of altering the duration of a conditioned stimulus (CS) for extinction. For the first 3 experiments, rats received conditioning with a 10-s CS before different groups received extinction with a CS that was either the same duration or longer than that used for conditioning. For the remaining 2 experiments, conditioning was conducted with a 60-s CS before different groups received extinction with a CS of either the same duration or a shorter duration than that used for conditioning. In all experiments, extinction progressed more readily when the CS duration was different for the 2 stages than when it was constant. The results are discussed in terms of rate expectancy theory and associative learning theory.

Animals↗

PubMed2003

Absence of overshadowing and blocking between landmarks and the geometric cues provided by the shape of a test arena.

In three experiments rats were required to escape from a pool of water by swimming to a submerged platform. The position of the platform was determined by the shape of the pool, which was either rectangular or triangular. A landmark that was located on the surface of the pool near the platform failed to overshadow (Experiment 1) or block (Experiment 2) learning about the position of the platform with reference to the shape of the pool. Experiment 3 revealed a similar outcome with cues outside the pool, which could be used, in addition to the shape of the pool, to identify the location of the platform. These findings imply that theories of learning that assume that stimuli must compete with each other for the control that they acquire may not apply to spatial learning based on the shape of the environment.

Association Learning↗

PubMed2002

Summation: further assessment of a configural theory.

when A+ B+ training was conducted in the absence of CD+ trials. A further failure to observe abnormally strong responding during AB was found in Experiment 3 for which the training trials with A+ B+ CD+ were accompanied by trials in which C and D were separately paired with food. The results are explained in terms of a configural theory of conditioning, which assumes that responding during a compound is determined by generalization from its components, as well as from other compounds to which it is similar.

Acoustic Stimulation↗

PubMed2002

The effects of using stimuli from three different dimensions on autoshaping with a complex negative patterning discrimination.

In two experiments pigeons received a complex negative patterning discrimination, using autoshaping, in which food was made available after three stimuli if they were presented alone (A, B, C), or in pairs (AB, AC, BC), but not when they were all presented together (ABC). Subjects also received a positive patterning discrimination in which three additional stimuli were not followed by food when presented alone (D, E, F), or in pairs (DE, DF, EF), but they were followed by food when presented together (DEF). Stimuli A and D belonged to one dimension, B and E to a second dimension, and D and F to a third dimension. For both problems, the discrimination between the individual stimuli and the triple-element compounds developed more readily than that between the pairs of stimuli and the triple-element compound. The results are consistent with predictions that can be derived from a configural theory of conditioning.

Analysis of Variance↗

PubMed2002

Evaluation and development of a connectionist theory of configural learning.

A configural theory of associative learning is described that is based on the assumption that conditioning results in associations between the unconditioned stimulus and a representation of the entire pattern of stimulation that was present prior to its delivery. Configural theory was formulated originally to account for generalization and discrimination in Pavlovian conditioning. The first part of the article demonstrates how this theory can be used to explain results from studies of overshadowing, blocking, summation, and discrimination learning. The second part of the article shows how the theory can be developed to explain a broader range of phenomena, including mediated conditioning, reinforcer devaluation effects, the differential outcomes effect, acquired equivalence, sensory preconditioning, and structural discriminations.

Animals↗

PubMed2002

Summation in autoshaping is affected by the similarity of the visual stimuli to the stimulation they replace.

Pigeons received autoshaping with 2 stimuli, A and B, presented in adjacent regions on a television screen. Conditioning with each stimulus was therefore accompanied by stimulation that was displaced from the screen whenever the other stimulus was presented. Test trials with AB revealed stronger responding if this displaced stimulation was similar to, rather than different from, A and B. For a further experiment the training just described included trials with A and B accompanied by an additional, similar, stimulus. Responding during test trials with AB was stronger if the additional trials signaled the presence rather than the absence of food. The results are explained with a configural theory of conditioning.

Animals↗

PubMed2002

Acquisition of superexcitatory properties by an irrelevant background stimulus.

Six appetitive conditioning experiments with rats demonstrated that an irrelevant X accompanying a negative patterning discrimination (XA+, XB+, XAB-) acquires extraordinarily high levels of conditioned excitation. Responding to X was similar to that evoked by 2 excitors in combination (Experiment 1) and was greater than responding to a separately reinforced Y (Experiments 2-5). Superexcitatory properties were not acquired by X in the nonpatterning discriminations of Experiments 2-4. Experiment 5 found that A and B, if anything, were weakly excitatory. Making them more strongly excitatory after conditioning did not interfere with retention of the original discrimination (Experiment 6). Results support a counterintuitive prediction of associative theories that, under carefully arranged conditions, irrelevant stimuli may acquire superexcitatory properties.

Animals↗