Biomedical subjects

John L Go

Publications and source records attributed to John L Go.

8 recordsLinked to original sources

PubMed2006

Imaging of primary central nervous system lymphoma.

Primary central nervous system lymphoma (PCNSL) is an aggressive neoplastic process that occurs in both immunocompetent and immunocompromised patients. Over the past 30 years there has been a steady increase in the number of cases in both patient populations. The imaging features for the disease and demographic characteristics within these patient populations vary, and in this article the authors describe the salient features of these two groups.

Brain Neoplasms↗

PubMed2005

MRI evaluation of neurofibromatosis 2 patients: a standardized approach for accuracy in interpretation.

OBJECTIVE: To determine the level of agreement between local radiologists' and an experienced neuroradiologist's measurements of vestibular schwannomas. STUDY DESIGN: Prospective study with uniform magnetic resonance acquisition protocol parameters and reporting instructions across 30 magnetic resonance imaging facilities worldwide. SETTING: Multicenter natural history study of neurofibromatosis Type 2. SUBJECTS: One hundred fifteen magnetic resonance imaging examinations of 57 neurofibromatosis Type 2 patients older than 5 years of age. INTERVENTIONS: Thin-slice, postcontrast cranial magnetic resonance imaging. MAIN OUTCOME MEASURES: Spearman's rho interobserver association coefficient of vestibular schwannoma linear measurements. RESULTS: The local and experienced radiologist measurements and identification of tumors agreement was fair (kappa = 0.77). Discordant interpretations were adjudicated by another experienced neuroradiologist. CONCLUSION: The least interobserver variability was found in measurements of thin-slice postcontrast magnetic resonance imaging scans obtained at neurofibromatosis Type 2 centers in patients without previous operations and moderately sized tumors. If the schwannoma was difficult to assess, because of magnetic resonance imaging acquisition protocol, postoperative changes, or tumors smaller than 5 mm in greatest diameter, the neuroradiologist provided a more thorough assessment. The authors suggest uniform reporting criteria for vestibular schwannoma assessments to ensure clinically relevant information is communicated regarding vestibular schwannoma size.

Adolescent↗

PubMed2005

MRI of cranial nerve enhancement.

OBJECTIVE: In this pictorial essay, we review the MR appearance of cranial nerve enhancement in a variety of entities including neoplastic, infectious, and idiopathic diseases. CONCLUSION: MRI with contrast enhancement is a valuable tool for detecting and characterizing disease of the cranial nerves. Abnormal cranial nerve enhancement on MRI may sometimes be the first or only indication of an underlying disease process.

Contrast Media↗

PubMed2003

Imaging of the pituitary and parasellar region.

The pituitary is part of a chain of enormous biologic amplification, which is regulated by a small amount of releasing factors in the portal blood from the hypothalamus. The pituitary is a master gland that regulates a number of hormones. A subtle abnormality in the pituitary can cause significant changes in body metabolism. Because the pituitary glands are small structures, high-resolution imaging techniques are required to satisfactorily evaluate the gland. It is imperative for the radiologist to be familiar with the anatomy, physiology, and pathology of the pituitary gland, which provides a solid foundation for accurate interpretation of the imaging studies of the pituitary gland.

Adenoma↗

PubMed2002

Cranial nerve XII: the hypoglossal nerve.

The hypoglossal nerve, cranial nerve XII, is the motor supply of the tongue. An understanding of the intracranial and extracranial components is fundamental in the evaluation of hypoglossal pathology. The following discussion of the evaluation of the hypoglossal nerve will involve the embryology, anatomy, clinical basis, and imaging techniques with pathologic correlations.

Humans↗

PubMed2002

Imaging of sequelae of head trauma.

The imaging of head trauma has been one of the fundamental cornerstones of neuroradiology. As the practice of neuroimaging has matured, great strides have been made in the diagnostic as well as prognostic armamentarium available to physicians. Given the vast diversity of trauma mechanisms and clinical pathways, new advanced imaging technologies have had a lasting impact on the detection, description, and depiction of head trauma. Furthermore, these new tools are allowing the imaging specialist to function not only as an interpreter of what is seen but as a 21st century radiographic oracle. We present a comprehensive review of the imaging findings of sequlae of traumatic brain injury and the growing correlation of new neuroimaging techniques and neurotraumatic outcomes.

Arachnoid Cysts↗

PubMed2002

Radiographic assessment of cranial gunshot wounds.

Though advances in MRI will undoubtedly increase its use, particularly in the subacute period, CT will likely continue its primary role in the management of these injuries in the foreseeable future. The spectrum of imaging features of cranial gunshot injuries is vast, because they encompass all of the findings encountered in closed head injury in addition to the wide variety of problems associated with penetration. Thus, only a brief summary of the many varied aspects of this complex problem is presented here as a review of the more salient issues.

Brain↗

PubMed2002

Orbital trauma.

Assessment of the orbit for orbital trauma is best achieved expeditiously with CT in the determination of extent of injury and the presence of foreign body. MR imaging has a limited role but is valuable in examining the optic nerve and globe for injury and has proven to be an adjunct modality in the assessment of orbital injury.

Eye Foreign Bodies↗