Biomedical subjects

John Kingston

Publications and source records attributed to John Kingston.

3 recordsLinked to original sources

PubMed2005

Environmentally stratified sampling design for the development of Great Lakes environmental indicators.

Understanding the relationship between human disturbance and ecological response is essential to the process of indicator development. For large-scale observational studies, sites should be selected across gradients of anthropogenic stress, but such gradients are often unknown for apopulation of sites prior to site selection. Stress data available from public sources can be used in a geographic information system (GIS) to partially characterize environmental conditions for large geographic areas without visiting the sites. We divided the U.S. Great Lakes coastal region into 762 units consisting of a shoreline reach and drainage-shed and then summarized over 200 environmental variables in seven categories for the units using a GIS. Redundancy within the categories of environmental variables was reduced using principal components analysis. Environmental strata were generated from cluster analysis using principal component scores as input. To protect against site selection bias, sites were selected in random order from clusters. The site selection process allowed us to exclude sites that were inaccessible and was shown to successfully distribute sites across the range of environmental variation in our GIS data. This design has broad applicability when the goal is to develop ecological indicators using observational data from large-scale surveys.

Animals↗

PubMed2005

The development of the EASE model.

The estimation and assessment of substance exposure (EASE) model has been under development and in use since the early 1990s. It is a general model that can be used to predict workplace exposure to any substance hazardous to health. The current EASE model (version 2.0) has been used widely in the risk assessment of new and existing chemicals by the UK Health and Safety Executive (HSE) and other regulatory agencies. EASE has also been distributed globally to over 200 users and therefore may have been used for many other purposes. Despite widespread use of the model, neither the development of its structure nor its underlying concepts and principles have been published in the open literature. Using surviving documentary evidence and discussions with key personnel, the creation and development of the model from 1992 to 2002 is described. The role of the HSE's National Exposure Database (NEDB) as the principal data source for the development of the model output exposure ranges is described. A number of problems and limitations of the model have been identified and the description of the model's development provides some explanation of their presence.

Expert Systems↗

PubMed2003

Learning foreign vowels.

Two hypotheses have recently been put forward to account for listeners' ability to distinguish and learn contrasts between speech sounds in foreign languages. First, Best's Perceptual Assimilation Model and Flege's Speech Learning Model both predict that the ease with which a listener can tell one non-native phoneme from another varies directly with the extent to which these sounds assimilate to different native phonemes (Best, 1994; also Best, McRoberts, & Goodell, 2001; Flege, 1991). Second, Logan, Lively, & Pisoni (1991) have argued that training listeners to identify non-native phonemes teaches them sets of exemplars rather than more abstract distinctive feature values. I report here the results of three sets of experiments designed to test these hypotheses, in which American English listeners were trained to categorize German nonlow vowels. The first set of experiments show that some instances of the same contrast between German vowels are more easily discriminated than others, a result incompatible with the predictions of either Best's or Flege's models, but compatible with the alternative category recognition interpretation. The second set of experiments reveals effects of contextual and speaker variation on listeners' ability to learn [tense] but not [high] contrasts between foreign vowels, and are thus at least partly compatible with an exemplar model of foreign category learning (Pisoni, Lively, & Logan, 1994; also Nosofsky, 1986). The third set of experiments compares the predictions of Nosofsky's (1986) selective attention exemplar model of category learning with those of a feature learning model in tests of listeners' learning the natural classes to which the German vowels belong. The results are mixed: listeners learned the features that define the natural classes of [+/- high] and [+/- back] vowels, but could have learned either the feature that defines the natural classes of [+/- tense] vowels or sets of [+/- tense] exemplars. Natural classes defined by abstract distinctive feature values are thus learnable, even if their membership is phonetically polymorphous.

Adult↗