Search PubMed⌕ Search

Biomedical subjects

John C Gore

Publications and source records attributed to John C Gore.

At least 37 records · Page 2Linked to original sources
PubMed2005

Temperature dependence of nuclear magnetization and relaxation.

The temperature dependences of nuclear magnetization and relaxation rates are reviewed theoretically and experimentally in order to quantify the effects of temperature on NMR signals acquired by common imaging techniques. Using common sequences, the temperature dependences of the equilibrium nuclear magnetization and relaxation times must each be considered to fully understand the effects of temperature on NMR images. The temperature dependence of the equilibrium nuclear magnetization is negative because of Boltzmann's distribution for all substances at all temperatures, but the combined temperature dependences of the equilibrium magnetization and relaxation can be negative, weak or positive depending on the temperature (T), echo time (T(E)), repetition time (T(R)), and the temperature dependences of the relaxation times T(1)(T) and T(2)(T) in a pulse sequence. As a result, the magnitude of the NMR signal from a given substance can decrease, increase or stay somewhat constant with increasing temperature. Nuclear thermal coefficients are defined and predictions for spin echo and other simple sequences are verified experimentally using a number of substances representing various thermal and NMR properties.

Animals↗
PubMed2005

Computer simulation studies of the effects of dynamic shimming on susceptibility artifacts in EPI at high field.

Dynamic shimming in multi-slice imaging aims to achieve optimal magnetic field homogeneity by updating the shim coil currents for each slice in real time. Dynamic shimming may reduce the signal loss and geometric distortion caused by magnetic susceptibility variations between tissues and is likely to be valuable for fast T2*-sensitive imaging techniques like EPI. A computer simulation of dynamic shimming using real image data has been developed to demonstrate the effectiveness of higher order dynamic shimming for echo planar imaging at high magnetic field, and to investigate the potential benefits of different orders of shim coil. Geometric distortions and signal intensities for different degrees of dynamic shimming were simulated and the results are compared with the images obtained with a conventional shimming technique. These results demonstrate the effectiveness, necessity and difficulty of high order dynamic shimming.

Artifacts↗
PubMed2005

Computing the B1 field of the toroidal MRI coil.

We present an analytic solution for the B1 field produced in a gapped toroidal cavity resonator designed as a probe for high field MRI. This resonator supports standing TEM waves, so its electric and magnetic fields are identical to those produced by a stationary planar current source with the same (constant) cross-section multiplied by a complex exponential propagation factor. An explicit expression for the field may therefore be found by solving Laplace's equation for the static potential, which is accomplished with a two-dimensional logarithmic conformal transformation algorithm. The equipotential curves are also the contours of the field strength B, and the B (vector) field at any point is directed along the contour passing through that point. With this information, we construct the solution by computing the angle made by the equipotential curve with the horizontal axis at each point, using this angle to analyze the B field into its x and y components, and adding the contributions from the current sources to obtain the magnitude and direction of B at each point in the region of interest. Some proposed extensions of this algorithm are also discussed.

Algorithms↗
PubMed2005

Quantification of multiple sclerosis lesion load and brain tissue volumetry using multiparameter MRI: methodology and reproducibility.

Quantitative characterization of multiple sclerosis (MS) lesion load is of considerable interest to clinical follow-up studies. Based on fuzzy clustering of multiparameter magnetic resonance images, we have developed a computer-assisted system for volumetric quantification of brain tissue. Tests on patient data show that the system is very efficient, and volumetric measurements characterized are highly reproducible. The high reproducibility and efficiency offer the potential of routine laboratory and clinical use for quantification of MS lesion load.

Algorithms↗
PubMed2005

Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model.

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can assess tumor perfusion, microvascular vessel wall permeability and extravascular-extracellular volume fraction. Analysis of DCE-MRI data is usually based on indicator dilution theory that requires knowledge of the concentration of the contrast agent in the blood plasma, the arterial input function (AIF). A method is presented that compares the tissues of interest (TOI) curve shape to that of a reference region (RR), thereby eliminating the need for direct AIF measurement. By assigning literature values for Ktrans (the blood perfusion-vessel permeability product) and v(e) (extravascular-extracellular volume fraction) in a reference tissue, it is possible to extract the Ktrans and v(e) values for a TOI without knowledge of the AIF. The operational RR equation for DCE-MRI analysis is derived, and its sensitivity to noise and incorrect assignment of the RR parameters is tested via simulations. The method is robust at noise levels of 10%, returning accurate (+/-20% in the worst case) and precise (+/-15% in the worst case) values. Errors in the TOI Ktrans and v(e) values scale approximately linearly with the errors in the assigned RR Ktrans and v(e) values. The methodology is then applied to a Lewis Lung Carcinoma mouse tumor model. A slowly enhancing TOI yielded Ktrans=0.039+/-0.002 min-1 and v(e)=0.46+/-0.01, while a rapidly enhancing region yielded Ktrans=0.35+/-0.05 min-1 and v(e)=0.31+/-0.01. Parametric Ktrans and v(e) mappings manifested a tumor periphery with elevated Ktrans (>0.30 min-1) and v(e) (>0.30) values. The main advantage of the RR approach is that it allows for quantitative assessment of tissue properties without having to obtain high temporal resolution images to characterize an AIF. This allows for acquiring images with higher spatial resolution and/or SNR, and therefore, increased ability to probe tissue heterogeneity.

Algorithms↗
PubMed2005

fMRI activation of the fusiform gyrus and amygdala to cartoon characters but not to faces in a boy with autism.

Abnormal hypoactivation in the amygdala and fusiform gyrus, brain areas that participate in face processing and social cognition, has consistently been demonstrated in persons with autism. We investigated activity in these areas in a boy with autism, DD, who had a special interest in "Digimon" cartoon characters. DD individuates Digimon faster than familiar faces and objects, but he individuates familiar faces no faster than objects. In contrast, a typically developing boy with an interest in "Pokemon" cartoon characters is equally fast at individuating faces and Pokemon and faster at individuating faces and Pokemon than objects and Digimon. In addition, using functional magnetic resonance imaging (fMRI), we show that DD activates his amygdala and fusiform gyrus for perceptual discriminations involving Digimon but not for those involving familiar or unfamiliar faces. This pattern of activation is not seen in the typically developing control with an interest in Pokemon or in a second comparison case who has autism but no interest in Digimon. These results have important implications for our understanding of autism, cortical face specialization, and the possible role of the amygdala in the development of perceptual expertise.

Amygdala↗
PubMed2004

Functional MRI changes before and after onset of reported emotions.

The social nature of emotion is evident in the importance of facial and vocal displays in emotion-related behavior. This is the first brain-imaging study to use simulated face-to-face social interactions to evoke emotional responses and to compare valence-related activations before and after subjective onset of emotional response. Videotapes were prepared with actresses who described happy or unhappy experiences. Functional magnetic resonance imaging (fMRI) at 1.5 T was used to acquire BOLD images in 21 healthy young adults before, after, and during viewing of the happy and sad tapes. Subjects pushed buttons to indicate the onset of subjective emotional responses. Group data were analyzed by a bootstrap randomization method after anatomical normalization. Significant activation was detected in frontal and sensory regions prior to the reported onset of emotional response, and this activity showed a marked decrease after the report of conscious emotional experience. Significant differences between happy and sad conditions were evident in multiple brain regions both before and after the reported onset of emotional response, including the middle and superior temporal gyri, the middle frontal gyrus, the caudate, and the hippocampus. Socially relevant emotional stimulation is feasible and evokes robust responses. The neural correlates of the evoked emotion are multiple, widely distributed, and inclusive of areas important in many cognitive tasks. Positive and negative emotional responses include activation of common and distinctive brain regions.

Adult↗
PubMed2004

Physiological basis of muscle functional MRI: predictions using a computer model.

Muscle functional MRI (mfMRI) has been proposed as a tool for noninvasively measuring the metabolic and hemodynamic responses to muscle activation, but its theoretical basis remains unclear. One challenge is that it is difficult to isolate individually those variables affecting the magnitude and temporal pattern of the mfMRI response. Therefore, the purpose of this study was to develop a computer model of how physiological factors altered during exercise affect the mfMRI signal intensity time course and then predict the contributions made by individual factors. A model muscle containing 39,204 fibers was defined. The fiber-type composition and neural activation strategies were designed to represent isometric contractions of the human anterior tibialis muscle, for which published mfMRI data exist. Sustained isometric contractions at 25 and 40% maximum voluntary contraction were modeled, as were the vascular (capillary recruitment, blood oxygen extraction) and metabolic (lactate accumulation, phosphocreatine hydrolysis, pH) responses. The effects on the transverse relaxation of MRI signal were estimated, and the mfMRI signal intensity time course was measured from simulated images. The model data agreed well qualitatively with published experimental data, and at long exercise durations the quantitative agreement was also good. The model was then used to predict that NMR relaxation effects secondary to blood volume and oxygenation changes, plus the creatine kinase reaction, dominate the mfMRI time course at short exercise durations (up to approximately 45 s) and that effects secondary to glycolysis are the main contributors at later times.

Animals↗
PubMed2004

Changes in functional connectivity of human MT/V5 with visual motion input.

The neural basis of human mental function is characterized by interactions between brain regions. Temporal correlations in MR signals between areas may provide one method for investigating these interactions. This approach was used to examine functional connectivity in the motion processing system of the human brain. Correlations between MT/V5 and other brain regions were examined in a resting state (without visual stimulation) and in an active state produced by viewing moving concentric circles. A network of regions consistent with the known functional anatomy of visual processing was correlated with MT/V5 during rest. When subjects were viewing motion, a more limited network was correlated with MT/V5, suggesting MT/V5 was acting in concert with a smaller network specific to the task.

Brain Mapping↗
PubMed2004

Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention.

BACKGROUND: A range of neurobiological investigations shows a failure of left hemisphere posterior brain systems to function properly during reading in children and adults with reading disabilities. Such evidence of a disruption in the normal reading pathways provides a neurobiological target for reading interventions. In this study, we hypothesized that the provision of an evidence-based, phonologically mediated reading intervention would improve reading fluency and the development of the fast-paced occipitotemporal systems serving skilled reading. METHODS: Functional magnetic resonance imaging was used to study the effects of a phonologically based reading intervention on brain organization and reading fluency in 77 children aged 6.1-9.4 years (49 with reading disability and 28 control subjects). Children comprised three experimental groups: experimental intervention (n = 37), community intervention (n = 12), and community control subjects (n = 28). RESULTS: Immediately after the year-long intervention, children taught with the experimental intervention had made significant gains in reading fluency and demonstrated increased activation in left hemisphere regions, including the inferior frontal gyrus and the middle temporal gyrus; 1 year after the experimental intervention had ended these children were activating bilateral inferior frontal gyri and left superior temporal and occipitotemporal regions. CONCLUSIONS: These data indicate that the nature of the remedial educational intervention is critical to successful outcomes in children with reading disabilities and that the use of an evidence-based phonologic reading intervention facilitates the development of those fast-paced neural systems that underlie skilled reading.

Child↗
PubMed2004

Simultaneous event-related potential and near-infrared spectroscopic studies of semantic processing.

Near-infrared optical topography (NIROT) signals and event-related potentials (ERPs) were measured simultaneously during a semantic processing task to evaluate the ability of these techniques to detect hemodynamic and electrophysiologic responses generated by semantic anomalies and to compare these results to earlier independent functional magnetic resonance imaging (fMRI) and ERP measurements. Candidate brain regions were first identified from activations detected by NIROT during a simple block-design task (in this case reading sentences vs. passive viewing), and defined regions (corresponding to Broca's and Wernicke's areas) were used for guiding the localization of optodes and electrodes for recording during tasks involving semantic anomalies. In five of six subjects, ERP measurements showed the characteristic N400 wave, whereas event-related NIROT showed results that agreed with previous fMRI studies. There were transient hemodynamic signals recorded in specific optodes that corresponded to activation in Broca's area, but slightly anterior to the region activated during the simple reading task, and in Wernicke's area, but slightly inferior to that for the simple reading task. A between-subject correlation of the ERP and NIRS data was also employed to identify areas of activation. The highest correlations were obtained in Broca's area, centered more anterior than for the reading task and in Wernicke's area, slightly inferior to that for the reading task. This study confirms that event-related studies are feasible using NIROT and produce results similar to those obtained with fMRI. Even though the spatial resolution is lower in NIROT than in fMRI, small differences in the locations of activation centers could be detected with NIROT. This, together with the feasibility of simultaneous ERP recording, makes NIROT attractive as a new approach to studying language function in healthy subjects as well as in those with functional abnormalities.

Adult↗
PubMed2004

New approach for correcting distortions in echo planar imaging.

A new method is described that can correct the distortions due to multiple off-resonance effects in echo planar imaging, including those caused by B(0) field inhomogeneities, eddy currents, and gradient waveform imperfections. The proposed method uses a phase encoded acquisition and is as effective as the method of Chen and Wyricz (Chen and Wyricz, Magn Reson Med 1999;41:1206-1213) in correcting for distortions. Unlike Chen and Wyricz's approach, this new method works directly in distorted space and requires fewer scans. It also avoids the difficulties of phase unwrapping inherent in field mapping methods. Results using this new method with phantoms and human head scans at 3.0 T demonstrate the efficacy of the method in correcting distortions in both spin echo echo planar imaging (EPI) and gradient echo EPI.

Artifacts↗
PubMed2004

Parametric design and correlational analyses help integrating fMRI and electrophysiological data during face processing.

Face perception is typically associated with activation in the inferior occipital, superior temporal (STG), and fusiform gyri (FG) and with an occipitotemporal electrophysiological component peaking around 170 ms on the scalp, the N170. However, the relationship between the N170 and the multiple face-sensitive activations observed in neuroimaging is unclear. It has been recently shown that the amplitude of the N170 component monotonically decreases as gaussian noise is added to a picture of a face [Jemel et al., 2003]. To help clarify the sources of the N170 without a priori assumptions regarding their number and locations, ERPs and fMRI were recorded in five subjects in the same experiment, in separate sessions. We used a parametric paradigm in which the amplitude of the N170 was modulated by varying the level of noise in a picture, and identified regions where the percent signal change in fMRI correlated with the ERP data. N170 signals were observed for pictures of both cars and faces but were stronger for faces. A monotonic decrease with added noise was observed for the N170 at right hemisphere sites but was less clear on the left and occipital central sites. Correlations between fMRI signal and N170 amplitudes for faces were highly significant (P < 0.001) in bilateral fusiform gyrus and superior temporal gyrus. For cars, the strongest correlations were observed in the parahippocampal region and in the STG (P < 0.005). Besides contributing to clarify the spatiotemporal course of face processing, this study illustrates how ERP information may be used synergistically in fMRI analyses. Parametric designs may be developed further to provide some timing information on fMRI activity and help identify the generators of ERP signals.

Adult↗
PubMed2004

Neuronal representation of occluded objects in the human brain.

Occluding surfaces frequently obstruct the object of interest yet are easily dealt with by the visual system. Here, we test whether neural areas known to participate in motion perception and eye movements are regions that also process occluded motion. Functional magnetic resonance imaging (fMRI) was used to assess brain activation while subjects watched a moving ball become occluded. Areas activated during occluded motion included the intraparietal sulcus (IPS) as well as middle temporal (MT) regions analogous to monkey MT/MST. A second experiment showed that these results were not due to motor activity. These findings suggest that human cortical regions involved in perceiving occluded motion are similar to regions that process real motion and regions responsible for eye movements. The intraparietal sulcus may be involved in predicting the location of an unseen target for future hand or eye movements.

Adolescent↗
PubMed2004

Separable neural components in the processing of black and white faces.

In a study of the neural components of automatic and controlled social evaluation, White participants viewed Black and White faces during event-related functional magnetic resonance imaging. When the faces were presented for 30 ms, activation in the amygdala-a brain region associated with emotion-was greater for Black than for White faces. When the faces were presented for 525 ms, this difference was significantly reduced, and regions of frontal cortex associated with control and regulation showed greater activation for Black than White faces. Furthermore, greater race bias on an indirect behavioral measure was correlated with greater difference in amygdala activation between Black and White faces, and frontal activity predicted a reduction in Black-White differences in amygdala activity from the 30-ms to the 525-ms condition. These results provide evidence for neural distinctions between automatic and more controlled processing of social groups, and suggest that controlled processes may modulate automatic evaluation.

Adult↗
PubMed2004

A nonmusical paradigm for identifying absolute pitch possessors.

The ability to identify and reproduce sounds of specific frequencies is remarkable and uncommon. The etiology and defining characteristics of this skill, absolute pitch (AP), have been very controversial. One theory suggests that AP requires a specific type of early musical training and that the ability to encode and remember tones depends on these learned musical associations. An alternate theory argues that AP may be strongly dependent on hereditary factors and relatively independent of musical experience. To date, it has been difficult to test these hypotheses because all previous paradigms for identifying AP have required subjects to employ knowledge of musical nomenclature. As such, these tests are insensitive to the possibility of discovering AP in either nonmusicians or musicians of non-Western training. Based on previous literature in pitch memory, a paradigm is presented that is intended to distinguish between AP possessors and nonpossessors independent of the subjects' musical experience. The efficacy of this method is then tested with 20 classically defined AP possessors and 22 nonpossessors. Data from these groups strongly support the validity of the paradigm. The use of a nonmusical paradigm to identify AP may facilitate research into many aspects of this phenomenon.

Adult↗