Biomedical subjects
Publications and source records attributed to Joanna Goździk.
A case of multiple brain tuberculosis in 32-year-old men was described. The diagnosis was made on the result of histopathological examination of excised tuberculoma. Basing on the described case, current possibilities of tuberculoma diagnostic difficulties, caused by unspecific clinical manifestation and atypical radiological lesions, was drawn.
Frédéric Chopin--a great Polish composer and pianist--suffered from a chronic disease. Both during his life and after death physicians disagreed on the subject of Chopin's diagnosis. His contemporaries accepted the diagnosis of a disease common in the 18th century--tuberculosis. Description of new clinical entities provoked new dilemmas in the 20th century. In our opinion the most tenable seems to be the diagnosis of cystic fibrosis. In this work we present F. Chopin's case history and discuss cons and pros for cystic fibrosis as the cause of F. Chopin's suffering and death.
Immotile cilia syndromes is a cause of recurrent infection of the airways and recurrent bronchopneumonias. Among the ciliary abnormalities are found changes in the structure of the microtubules, unco-ordinated ciliary movements caused by the absence of inner or outer or both dynein arms, and abnormalities of the kinetosomes and/or rete ridges. In patients with ciliary dyskinaesia bronchitis occurs early in life (during infancy) and usually has a recurrent tendency, so that bronchial biopsy is frequently undergone for diagnostic purposes. In this study we include 127 bronchial biopsies from patients (from 2 months to 49 years) unsuccessfully treated for recurrent respiratory tract infections. When performing regular diagnostic procedures on the light and electron microscopic level, we have looked for cilia abnormalities and also focused on changes within the mucosa and submucosa. The most common abnormality recorded was absence of the inner dynein arms, but in 40 cases neither of the dynein arms were present. Only a few patients had classical Kartagener's syndrome. Special attention is drawn to biopsies from elderly patients, in whom long-standing infections were followed by extensive damage to the bronchial epithelium, including even a total absence of ciliated cells. In some cases enhanced regenerative processes and some foci of squamous metaplasia were found. In two cases even foci of low-grade dysplasia were diagnosed.
Mechanisms that connect immunoinflammatory disturbances with enhanced bone resorption in patients with rheumatoid arthritis and potential methods of prevention and management of bone involvement in these patients are reviewed.