Biomedical subjects

Joël Chavas

Publications and source records attributed to Joël Chavas.

3 recordsLinked to original sources

PubMed2005

Source coding by efficient selection of ground-state clusters.

We analyze the geometrical structure of clusters of ground states which appear in many frustrated systems over random graphs. Focusing on the regime of connectivities where the number of clusters is exponential in the size of the problems, we identify an appropriate generalization of the survey propagation equations efficiently exploring the geometry. The possibility of selecting different clusters has also computational consequences. As a proof of concept here we show how a well-known physical system can be used to perform nontrivial data compression, for which we introduce a unique compression scheme. Performances are optimized when the number of well-separated clusters is maximal in the underlying physical model.

Journal Article↗

PubMed2004

Osmotic tension as a possible link between GABA(A) receptor activation and intracellular calcium elevation.

Intracellular calcium concentration rises have been reported following activation of GABA(A) receptors in neonatal preparations and attributed to activation of voltage-dependent Ca(2+) channels. However, we show that, in cerebellar interneurons, GABA(A) agonists induce a somatodendritic Ca(2+) rise that persists at least until postnatal day 20 and is not mediated by depolarization-induced Ca(2+) entry. A local Ca(2+) elevation can likewise be elicited by repetitive stimulation of presynaptic GABAergic afferent fibers. We find that, following GABA(A) receptor activation, bicarbonate-induced Cl(-) entry leads to cell depolarization, Cl(-) accumulation, and osmotic tension. We propose that this tension induces the intracellular Ca(2+) rise as part of a regulatory volume decrease reaction. This mechanism introduces an unexpected link between activation of GABA(A) receptors and intracellular Ca(2+) elevation, which could contribute to activity-driven synaptic plasticity.

Animals↗

PubMed2003

Coexistence of excitatory and inhibitory GABA synapses in the cerebellar interneuron network.

Functional GABA synapses are usually assumed to be inhibitory. However, we show here that inhibitory and excitatory GABA connections coexist in the cerebellar interneuron network. The reversal potential of GABAergic currents (E(GABA)) measured in interneurons is relatively depolarized and contrasts with the hyperpolarized value found in Purkinje cells (-58 and -85 mV respectively). This finding is not correlated to a specific developmental stage and is maintained in the adult animal. E(GABA) in interneurons is close to the mean membrane potential (-56.5 mV, as measured with a novel "equal firing potential" method), and both parameters vary enough among cells so that the driving force for GABA currents can be either inward or outward. Indeed, using noninvasive cell-attached recordings, we demonstrate inhibitory, excitatory, and sequential inhibitory and excitatory responses to interneuron stimulation [results obtained both in juvenile (postnatal days 12-14) and subadult (postnatal days 20-25) animals]. In hyperpolarized cells, single synaptic GABA currents can trigger spikes or trains of spikes, and subthreshold stimulations enhance the responsiveness to subsequent excitatory stimulation over at least 30 msec. We suggest that the coexistence of excitatory and inhibitory GABA synapses could either buffer the mean firing rate of the interneuron network or introduce different types of correlation between neighboring interneurons, or both.

Action Potentials↗