Biomedical subjects

Jie Kang

Publications and source records attributed to Jie Kang.

At least 19 recordsLinked to original sources

PubMed2026

Constipation and Psychiatric Disorders: A Bidirectional Mendelian Randomization Study.

BACKGROUND: Observational studies have shown a link between constipation (CN) and psychiatric disorders, including Schizophrenia (SP), Bipolar disorder (BD), Schizoaffective disorder (SD), and Parkinson's disease (PD). However, it is still unknown whether CN affects the occurrence and development of psychiatric disorders or whether psychiatric disorders cause the occurrence and development of CN. Therefore, this study used Mendelian randomization (MR) analysis to evaluate the relationship between CN and psychiatric disorders. METHOD: We used genome-wide association studies (GWAS) to assess the relationship between constipation (N = 411, 623) and four psychiatric disorders, including SP ( N = 77, 096), BD (N = 51, 710), SD ( N = 210, 962), PD (N = 482, 730 ), using bidirectional MR analysis. Inverse variance weighting (IVW), MR Egger (ME) and Weighted median (WM) were used as causal analysis methods. Cochran's Q test, funnel plot, MR Egger intercept test and Leave.one.out analysis were used to detect sensitivity. Confounding factors were analyzed and eliminated by LDtrait to avoid influencing the final MR Analysis result. RESULTS: The results of positive MR analysis indicated that there was no evidence of influence of constipation on SP (OR 1.043, 95%CI 0.946 - 1.149, P value = 0.398), BD (OR 1.114, 95%CI 0.995 - 1.248, P value = 0.062), SD (OR 0.934, 95%CI 0.674 - 1.294, P value = 0.682) and PD (OR 1.118, 95%CI 0.918 - 1.361, P value = 0.269) under gene prediction. Reverse MR analysis suggested that SP (OR 1.030, 95% CI 1.001-1.060, P value = 0.042) had a causal relationship with constipation. BD (OR 0.993, 95% CI 0.962-1.025, P value = 0.664), SD (OR 1.021, 95% CI 0.984-1.059, P value = 0.265) and PD (OR 1.004, 95% CI 0.974-1.035, P value = 0.790) were not associated with CN. CONCLUSION: There was a positive association between SP and CN. CN may have no exact causal relationship with BD, SD and PD, and the interaction mechanism between these diseases needs to be further explored.

Constipation↗

PubMed2006

Five new diels-alder type adducts from the stem and root bark of Morus mongolica.

Five new Diels-Alder type adducts, mongolicins A - E, and nine known compounds, mongolicin F, chalcomoracin, mulberrofuran T, mulberrofuran G, mulberrofuran F, albanol B, kuwanon O, mulberrofuran H and kuwanon H, were isolated from the stem and root bark of Morus mongolica. Their structures were determined by spectroscopic analysis and chiroptical methods. Among them, compounds and showed potent anti-inflammatory activities (inhibition of release of beta-glucuronidase from rat PMNs induced by PAF) with inhibitory ratios of 80.4% (P<0.05) and 77.0% (P<0.001) at a concentration of 10(-5) mol L-1. Compounds and were active as antioxidatives (inhibition of liver microsomal lipid peroxidation induced by Fe2+-Cys system) with inhibitory ratios of 83.6% (P<0.05), 86.0% (P<0.05), and 63.0% (P<0.05) at a concentration of 10(-5) mol L-1.

Anti-Inflammatory Agents↗

PubMed2006

Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes.

The effects of creatine and creatine plus beta-alanine on strength, power, body composition, and endocrine changes were examined during a 10-wk resistance training program in collegiate football players. Thirty-three male subjects were randomly assigned to either a placebo (P), creatine (C), or creatine plus beta-alanine (CA) group. During each testing session subjects were assessed for strength (maximum bench press and squat), power (Wingate anaerobic power test, 20-jump test), and body composition. Resting blood samples were analyzed for total testosterone, cortisol, growth hormone, IGF-1, and sex hormone binding globulin. Changes in lean body mass and percent body fat were greater (P < 0.05) in CA compared to C or P. Significantly greater strength improvements were seen in CA and C compared to P. Resting testosterone concentrations were elevated in C, however, no other significant endocrine changes were noted. Results of this study demonstrate the efficacy of creatine and creatine plus beta-alanine on strength performance. Creatine plus beta-alanine supplementation appeared to have the greatest effect on lean tissue accruement and body fat composition.

Adult↗

PubMed2006

Validation of Omni scale of perceived exertion during prolonged cycling.

PURPOSE: The present investigation was conducted to validate the OMNI ratings of perceived exertion (RPE) scale during prolonged cycle exercise when subjects were supplemented with either carbohydrate or placebo. METHODS: Fifteen trained cyclists cycled for 2.5 h at approximately 60% maximal watts on two occasions while receiving 4 mL x kg(-1) x 15 min(-1) carbohydrate (6%) (C) or placebo (P) beverages in a randomized, counterbalanced design. Concurrent and construct validity was established by evaluating perceptual responses with both the OMNI and Borg RPE scales every 20 min throughout the trials. RESULTS: The pattern of change in RPE over time was significantly different between C and P ingestion (P < 0.05), with an attenuated RPE response in C found at the hundredth minute for both the OMNI and Borg scales. The pattern of change in the respiratory exchange ratio and carbohydrate oxidation rates were significantly greater (P < 0.001) in the C than P condition. RPE-OMNI was positively and linearly related to the RPE-BORG; r = 0.60-0.98 (P < 0.01) throughout exercise for both the C and P conditions. CONCLUSIONS: Concurrent and construct evidence supports the use of the OMNI-cycle scale by adult men to estimate RPE during prolonged cycle exercise under differing conditions of carbohydrate supplementation.

Adult↗

PubMed2006

[Effect of rolling needle therapy on quality of life in the patient of non-organic chronic insomnia: a randomized controlled trial].

OBJECTIVE: To probe therapeutic effect of rolling needle therapy on insomnia and standardize the therapeutic program. METHODS: Multi-central randomized blind controlled trials were used, and 180 cases were randomly divided into a rolling needle group and a medication group, 90 cases in each group. The rolling needle group were treated with rolling needle therapy at the Urinary Bladder Channel line 1 and 2 at the back and the Governor Vessel, and the medication group with clonopin 4-6 mg, for 4 weeks. Effective rates for sleep disturbance improvement and Spitzer index of life quality were evaluated after 4 weeks' treatment and 3 months' follow-up. RESULTS: The effective rate was 82.2% in the rolling needle group and 60.0% in the medication group with a significant difference between the two groups (P < 0.05), and with a significant difference between the two groups in Spitzer index of life quality (P < 0.05). After 3 months' follow-up, the effective rate was 40.0% in the rolling needle group and 30.3% in the medication group with no significant difference between the two groups (P > 0.05), and there was a significant difference between the two groups in Spitzer index of life quality. CONCLUSION: Rolling needle therapy can treat chronic insomnia and increase life quality of the patient.

Acupuncture Therapy↗

PubMed2005

A new isopimarane-type diterpene and a new natural atisane-type diterpene from Excoecaria agallocha.

From the woods of Excoecaria agallocha, a new isopimarane-type diterpene, 3alpha,11beta-dihydroxy-ent-isopimara-8(14),15-dien-2-one and a new natural atisane-type diterpene, 16beta-hydroxy-ent-atisan-3-one were isolated together with three known compounds, ribenone, ent-labda-8(17),13E-diene-3beta,15-diol, and ent-3beta-hydroxybeyer-15-ene-2,12-dione. Their structures were determined by spectral data and x-ray crystallography evidence.

Diterpenes↗

PubMed2005

Metabolic and perceptual responses during Spinning cycle exercise.

PURPOSE: The present investigation was undertaken to compare metabolic and perceptual responses between exercise performed at constant intensity (CON) and with a Spinning protocol of variable intensity (VAR). METHOD: Fifteen subjects, including seven males and eight females (23 +/- 5 yr, 72 +/- 17 kg, and 171 +/- 10 cm), underwent two experimental trials. During each trial, subjects performed a 30-min cycle exercise protocol that was followed by a 30-min recovery period. Exercise was performed at 67 +/- 3% (means +/- SD) of HR(max) in CON. In VAR, the similar intensity (68 +/- 4% HR(max)) was also achieved, although the protocol entailed alternating phases of both higher and lower intensity arranged similarly to what is designed for a typical Spinning workout. Oxygen uptake (VO2) and HR were measured at rest and throughout both exercise and recovery, whereas RPE were recorded during exercise only. Plasma lactate concentrations [La] were determined at rest, the end of exercise, and the end of recovery. RESULTS: No differences in average VO2, HR, and RPE were found during exercise between CON and VAR. However, average VO2 and HR were higher (P < 0.05) in VAR than CON (0.33 +/- 0.03 vs 0.26 +/- 0.02 L x min(-1) and 91 +/- 3 vs 80 +/- 2 beats x min(-1), respectively). [La] was higher (P < 0.05) at the end of exercise in VAR than CON (7.2 +/- 0.8 vs 2.7 +/- 0.3 mmol x L(-1)), but became similar at the end of recovery. CONCLUSION: An exercise regimen in which intensity varies exerts no added effect on metabolic and perceptual responses during exercise as long as the average intensity is kept the same. However, VAR resulted in a greater [latin capital V with dot above]O2 after exercise, and this augmented postexercise oxygen consumption may be mediated in part by elevated plasma [La].

Adult↗

PubMed2005

Biochemical and hormonal responses during an intercollegiate football season.

PURPOSE: Changes in biochemical indices of muscle damage and hormonal markers of stress were examined during a competitive intercollegiate football season. METHODS: Twenty-one members of an NCAA Division III football team volunteered to serve as subjects. Eleven of these subjects were starters (ST) and 10 were non-starters (NS). All subjects reported to the Human Performance Laboratory on five separate occasions for blood draws. The first testing session (T1) occurred 1 d before the start of pre-season training camp, the second testing session (T2) occurred at the end of training camp (10 d later), and the other three testing sessions occurred at weeks 3 (T3), 7 (T4), and 11 (T5) of the competitive season. RESULTS: Significant elevations in creatine kinase (CK) were seen from T1 to T2 in both ST and NS. ST had significantly higher CK concentrations at T2 than NS. CK concentrations for both groups returned to baseline levels by T3 and remained constant for the rest of the season. No significant between-group differences were seen in myoglobin (MB), testosterone (TE), cortisol (C), or the testosterone/cortisol ratio (T/C) during the season. A significant main effect for time was seen for C and T/C. C concentrations were significantly lower at T2 than at T1, T3, T4, and T5. Similar changes were also seen for T/C. CONCLUSION: CK elevations seen during T2 appear to reflect the high intensity and physical nature of training camp. However, biochemical and endocrine responses during a season of intercollegiate football competition suggest a degree of sensitization (contact adaptation) of the muscles relating to the repeated traumas occurring during the season.

Adult↗

PubMed2005

Evaluation of physiological responses during recovery following three resistance exercise programs.

The present study was conducted to examine (a) whether there is an association between maximal oxygen uptake (Vo(2)max) and reduction in postexercise heart rate (HR) and blood lactate concentrations ([La]) following resistance exercise and (b) how intensity and Volume of resistance exercise affect postexercise Vo(2). Eleven regularly weight-trained males (20.8 +/- 1.3 years; 96.2 +/- 14.4 kg, 182.4 +/- 7.3 cm) underwent 4 sets of squat exercise on 3 separate occasions that differed in both exercise intensity and volume. During each testing session, subjects performed either 15 repetitions.set(-1) at 60% of 1 repetition maximum (1RM) (L), 10 repetitions.set(-1) at 75% of 1RM (M), or 4 repetitions.set(-1) at 90% of 1RM (H). During each exercise, Vo(2) and HR were measured before (PRE), immediately post (IP), and at 10 (10P), 20 (20P) 30 (30P), and 40 (40P) minutes postexercise. The [La] was measured at PRE, IP, 20P, and 40P. Decrease in HR (DeltaHR) was determined by subtracting HR at 10P from that at IP, whereas decrease in [La] (Delta[La]) was computed by subtracting [La] at 20P from that at IP. A significant correlation (p < 0.05) was found between Vo(2)max and DeltaHR in all exercise conditions. A significant correlation (p < 0.05) was also found between Vo(2)max and Delta[La] in L and M but not in H. The Vo(2) was higher (p < 0.05) during M than H at IP and 10P, while no difference was seen between L and M and between L and H. These results indicate that those with greater aerobic capacity tend to have a greater reduction in HR and [La] during recovery from resistance exercise. In addition, an exercise routine performed at low to moderate intensity coupled with a moderate to high exercise volume is most effective in maximizing caloric expenditure following resistance exercise.

Adaptation, Physiological↗

PubMed2005

The effect of a competitive collegiate football season on power performance and muscle oxygen recovery kinetics.

Ten intercollegiate football players were tested within 3 days prior to (T1) and the day following the end (T2) of football preseason training camp and during weeks 7 (T3) and 11 (T4) of the competitive season. During each testing session, subjects performed a 30-second Wingate anaerobic power test. Near-infrared continuous wave spectroscopy was used to measure muscle deoxygenation during exercise. No changes in any power performance measures were seen during the competitive football season. A significant (p < 0.05) decrease in the extent of deoxygenation during exercise was observed between T2 (72.6 +/- 19.4%) and T4 (50.2 +/- 14.2%). A 30 and 29% difference (p < 0.05) in the onset of reoxygenation was observed between T1 and T3 and T4, respectively. A 51% decrease (p < 0.05) in halftime recovery was observed between T2 and T3. Results indicate that the extent of muscle deoxygenation is reduced during high-intensity exercise and that muscle oxygen recovery kinetics improves over the duration of a competitive season of football.

Adult↗

PubMed2005

Effect of low-dose, short-duration creatine supplementation on anaerobic exercise performance.

To examine the efficacy of a low-dose, short-duration creatine monohydrate supplement, 40 physically active men were randomly assigned to either a placebo or creatine supplementation group (6 g of creatine monohydrate per day). Testing occurred before and at the end of 6 days of supplementation. During each testing session, subjects performed three 15-second Wingate anaerobic power tests. No significant (p > 0.05) group or time differences were observed in body mass, peak power, mean power, or total work. In addition, no significant (p > 0.05) differences were observed in peak power, mean power, or total work. However, the change in the rate of fatigue of total work was significantly (p < 0.05) lower in the creatine supplementation group than in the placebo group, indicating a reduced fatigue rate in subjects supplementing with creatine compared with the placebo. Although the results of this study demonstrated reduced fatigue rates in patients during high-intensity sprint intervals, further research is necessary in examining the efficacy of low-dose, short-term creatine supplementation.

Adult↗

PubMed2005

Comparison of loaded and unloaded jump squat training on strength/power performance in college football players.

The purpose of this study was to explore the effects of 5 weeks of eccentrically loaded and unloaded jump squat training in experienced resistance-trained athletes during the strength/ power phase of a 15-week periodized off-season resistance training program. Forty-seven male college football players were randomly assigned to 1 of 3 groups. One group performed the jump squat exercise using both concentric and eccentric phases of contraction (CE; n = 15). A second group performed the jump squat exercise using the concentric phase only (n = 16), and a third group did not perform the jump squat exercise and served as control (CT; n = 16). No significant differences between the groups were seen in power, vertical jump height, 40-yd sprint speed and agility performance. In addition, no differences between the groups were seen in integrated electromyography activity during the jump squat exercise. Significant differences between the CE and CT groups were seen in Delta 1RM squat (65.8 and 27.5 kg, respectively) and Delta 1RM power clean (25.9 and 3.8 kg, respectively). No other between-group differences were observed. Results of this study provide evidence of the benefits of the jump squat exercise during a short-duration (5-week) training program for eliciting strength and power gains. In addition, the eccentric phase of this ballistic movement appears to have important implications for eliciting these strength gains in college football players during an off-season training program. Thus, coaches incorporating jump squats (using both concentric and eccentric phases of contraction) in the off-season training programs of their athletes can see significant performance improvements during a relatively short duration of training.

Adult↗

PubMed2005

Carbohydrate supplementation and perceived exertion during resistance exercise.

The purpose of the present study was to investigate the relationship between carbohydrate energy substrate and the perception of exertion during resistance exercise. Thirty strength-trained subjects were randomized to a carbohydrate group (C) or a placebo group (P), and lifted weights for 2 hours (4 sets; 10 repetitions maximum; 10 exercises; 2-3-minute rest intervals). Subjects ingested 10 ml.kg(-1).h(-1) of 6% carbohydrate or placebo beverages during the resistance-training bout. The 15-category Borg Perceived Exertion Scale was used to assess overall body (RPE-O) and active muscle (RPE-AM) perceived exertion after completion of the last repetition in each set for each exercise. No significant differences were found between the C and P groups for either RPE-O or RPE-AM, with the exception of RPE-O for the upright row and back squat (p < 0.05). Carbohydrate supplementation exerted no attenuating effect on ratings of perceived exertion (RPE) during resistance training.

Adult↗

PubMed2005

[Studies on chemical constituents in the mycelia from fermented culture of Flammulina velutipes].

OBJECTIVE: To study the chemical constituents from the mycelia of Flammulina velutipes. METHOD: The compounds were isolated with silica gel column chromatography and their structures were elucidated on the basis of chemical evidences and spectral analysis (IR, EI-MS, 1H-NMR, 13C-NMR). RESULT: Five compounds were identified as 5alpha,8alpha-epidioxy-(22E,24R)-ergost-6,22-dien-3beta-ol (1), ergosta-4,6,8(14),22-tetraen-3-one (2), sterpuric acid (3), mannitol (4), ribitol (5). CONCLUSION: The compounds (2)-(5) were isolated for the first time from the mycelia of Flammulina velutipes.

Agaricales↗

PubMed2005

[A systematic evaluation of randomized controlled trials for acupuncture and moxibustion treatment of insomnia].

OBJECTIVE: To assess the therapeutic effect of acupuncture on insomnia. METHODS: A systematic evaluation of all relevant randomized controlled trials (RCT) about acupuncture and moxibustion treatment of insomnia was carried out. The data were statistically analyzed with a special software RevMan 4.1. RESULTS: Six papers of RCT including 585 patients met the enrolled criteria. All of the trials were of lower in methodological quality without using blind method; Meta-analysis indicated that odds ratio was 3.55, 95% confidence interval [2.50, 5.05], P < 0.0001, as acupuncture group compared with drug group. CONCLUSION: Acupuncture is possibly effective for insomnia. However, because of lower methodological quality of all the trials, this conclusion has no enough evidence.

Acupuncture↗

PubMed2004

RNA interference: PCR strategies for the quantification of stable degradation-fragments derived from siRNA-targeted mRNAs.

mRNA targeted by siRNA is endogeneously cleaved into a 5'- and a 3'-fragment and finally degraded in cells. Little is known about the relative stability and degradation kinetics of these 5'- and 3'-fragments after the siRNA mediated first cut. We present a qRT-PCR protocol which allows the determination of the optimal time point for mRNA analyses, helping to avoid the generation of false positive effects in downstream experiments, such as microarray analysis, which may be caused by undegraded fragments of a siRNA-targeted mRNA.

Gene Silencing↗

PubMed2004

Carbohydrate supplementation and perceived exertion during prolonged running.

PURPOSE: The purpose of this study was to investigate the relationship between carbohydrate energy substrate and hormonal regulation on the perception of exertion during prolonged running. METHODS: Sixteen experienced marathoners ran on treadmills for 3 h at approximately 70% VO2max on two occasions while receiving 1 L x h carbohydrate (C) or placebo (P) beverages. Blood and vastus lateralis muscle biopsy samples were collected before and after exercise. RESULTS: The pattern of change in ratings of perceived exertion (RPE) over time was significantly different between C and P ingestion (P < 0.01) with attenuated RPE responses found in the latter part of the 3 h run. The pattern of change in the respiratory exchange ratio and carbohydrate oxidation rates were significantly greater (P < 0.01) in the C than P condition. Change in muscle glycogen content did not differ between C and P (P = 0.246). C relative to P ingestion was associated with higher plasma levels of glucose, insulin, and lactate and lower levels plasma cortisol. CONCLUSIONS: These data indicate that a lower RPE was associated with a higher carbohydrate oxidation, plasma glucose, and insulin levels, and lower plasma cortisol during prolonged running after C supplementation as compared with P feeding despite no differences in muscle glycogen content. These findings support a physiological link between RPE and carbohydrate substrate availability as well as selected hormonal regulation during prolonged running.

Adult↗

PubMed2004

Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training.

Twenty-six members of a collegiate football team were randomly assigned to either a supplement (S) (3 g of beta-hydroxy beta-methylbutyrate [HMB] per day) or placebo (P) group. Testing occurred before (PRE) and at the end of 10 days of preseason football training camp (POST). During each testing session, subjects performed an anaerobic power test, and blood samples were obtained for testosterone, cortisol, creatine kinase, and myoglobin analysis. No differences in anaerobic power were seen between PRE and POST in either group. Cortisol concentrations were significantly decreased from PRE (333 +/- 81 nmol.L(-1)) to POST (246 +/- 79 nmol.L(-1)), and a sixfold increase was seen in creatine kinase concentrations at POST. However, no significant differences between the groups were seen. No significant time or group effects were observed in testosterone or myoglobin concentrations. Results suggest that short duration HMB supplementation does not provide any ergogenic benefit in collegiate football players during preseason training camp.

Administration, Oral↗