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Biomedical subjects

Jianping Xie

Publications and source records attributed to Jianping Xie.

21 records · Page 2Linked to original sources
PubMed2002

[The clinical significance of plasma endothelin measurement in acute organophosphorus pesticide poisoning].

OBJECTIVE: To investigate the clinical significance of plasma endothelin (ET) contents in patients with acute organophosphorus pesticide poisoning (AOPP). METHODS: 69 cases of AOPP were divided into 3 groups: mild poisoning, moderate poisoning and severe poisoning groups. 25 healthy subjects served as controls. The contents of plasma ET of the patients and healthy subjects were determined. RESULTS: No significant difference was noted between the contents of plasma ET of the control and the mild group (50.85 +/- 8.93) ng/L vs (56.18 +/- 12.80) ng/L, P > 0.05. The contents of plasma ET of mild cases were only slightly increased. The contents of plasma ET in the moderate (72.61 +/- 14.21 ng/L) and serve group (110.32 +/- 17.38 ng/L) were significantly higher than those of the control group (P < 0.01, P < 0.01). The contents of plasma ET in the moderate were significantly higher than those of the mild group (P < 0.01). The contents of plasma ET in the serve group were significantly higher than those of the moderate (P < 0.01). CONCLUSION: With the increase of AOPP severity, the contents of plasma ET elevated gradually. Plasma ET may serve as an important index for the clinical course, therapeutic efficacy and prognosis of AOPP. Early regression of the contents of plasma ET may play an active role in preventing and curing multiple system organ failure resulted from AOPP and in improving the prognosis.

Acute Disease↗
PubMed2002

[Characterization of genome of A/Guangzhou/333/99(H9N2) virus].

BACKGROUND: To understand the characterization of genome of a strain of avian influenza A H9N2 virus repeatedly isolated from a child with influenza illness. Thereafter to reveal the origin of this H9N2 virus. METHODS: Viruses were passed in embryonated hen eggs and virion RNA was extracted from allantoic fluid and reverse transcribed to synthesize cDNA. cDNA was amplified by PCR and the PCR product was purified with a purification kit. Afterwards RNA sequence analysis was performed by dideoxynucleotide chain termination and a cloning method. Finally, phylogenetic analysis of the sequencing data was performed with MegAlign (Version 1.03) and Editseg (Version 3.69) softwares. RESULTS: Genome of A/Guangzhou/333/99 (H9N2) virus was closely related to avian influenza A H9N2 virus, but obvious difference from that of A/Duck/Hong Kong/Y439/97(H9N2) virus, as well as its genome did not include any RNA segment derived from human influenza A virus. However, the genes encoding the HA,NA,NP and NS proteins of A/Guangzhou/333/99 virus were derived from those of G9 lineage virus, the rest genes encoding the M and three polymerase (PB2,PB1 and PA) proteins were derived from G1 lineage strain. CONCLUSIONS: A/Guangzhou/333/99 virus was a reassortant derived from reassortment betweenG9 and G1 lineages of avian influenzaA(H9N2) viruses. Therefore, the most possibility is that it is derived from avian influenza A virus directly. The results do not only demonstrate that avian influenza A (H9N2) virus could infect men, but also firstly prove that the genetic reassortment could be occurred between different genetic lineages of avian influenza A (H9N2) viruses in the nature.

Animals↗