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Biomedical subjects

Jesse Weinberger

Publications and source records attributed to Jesse Weinberger.

24 records · Page 2Linked to original sources

Prevention of Ischemic Stroke.

The primary risk factors for stroke are known, and attention to primary care of these disorders should reduce the incidence of stroke significantly. Control of hypertension, diabetes, and hyperlipidemia have all been shown to reduce the rate of stroke. Identification of potential cardioembolic sources of stroke, particularly atrial fibrillation, can prevent stroke with appropriate application of anticoagulation. Duplex Doppler B-mode sonography can establish the extent of carotid artery disease in patients with cervical bruit or risk factors for atherosclerosis, and indicate which conditions should be managed medically or surgically. Patients with a history suggestive of transient ischemic attacks can also be screened noninvasively with duplex sonography to determine if they have a critical carotid stenosis and require carotid endarterectomy. New advances in platelet antiaggregant therapy with ticlopidine, clopidogrel, and the combination of aspirin with dipyridamole have also reduced the rate of stroke to a greater degree than standard treatment with aspirin. The incidence of this devastating illness could possibly be reduced by 50% with attentive primary care management. The cardiologist is often involved in the treatment of patients at risk for stroke, and is in an ideal position to provide this care.

Journal Article↗

Noninvasive imaging of atherosclerotic plaque in the arch of the aorta with transcutaneous B-mode ultrasonography.

Atherosclerotic plaque at the arch of the aorta has been identified as a potential source for atheroembolic stroke. Imaging of aortic arch plaque can be performed with transesophageal echocardiography (TEE), but TEE is an invasive procedure. A new noninvasive method has been developed to image aortic arch plaque employing transcutaneous real time B-mode ultrasonography with color flow duplex Doppler. B-mode imaging has an 86% accuracy for identifying complex aortic arch plaques as compared with TEE. Noninvasive imaging of the aortic arch can be employed in diagnosing the etiology of cerebrovascular disease in patients with stroke or transient ischemic attack in conjunction with duplex B-mode sonography of the extracranial carotid arteries. It also provides a noninvasive method for studying atherosclerotic plaque in the aortic arch which is applicable for investigational studies of the mechanisms of atherosclerosis and evaluation of pharmacological agents designed to treat atherosclerotic disease.

Aorta, Thoracic↗

Stroke and TIA. Prevention and management of cerebrovascular events in primary care.

Stroke is a major cause of death and disability in the United States. Control of risk factors--particularly hypertension, diabetes, elevated serum lipids, and atrial fibrillation--can significantly reduce the incidence of stroke. Platelet antiaggregant therapy has a role in primary and secondary stroke prevention. Patients with transient ischemic attacks presenting with carotid stenosis > 70% can be managed surgically, whereas those with less stenosis can be treated with platelet antiaggregant therapy. Acute stroke is a medical emergency. Thrombolytic therapy with tissue plasminogen activator within 3 hours of event onset can significantly improve outcomes in selected ischemic stroke patients. Patients with intracerebral hemorrhage usually present with acute onset of identifiable neurologic deficits.

Aged↗

Drug therapy of neurovascular disease.

Recent advances in the prevention and pharmacotherapy of cerebrovascular disease have provided more favorable clinical outcomes. For the treatment of an acute ischemic stroke, the early use of thrombolytic agents can reduce the degree of brain damage while improving functional outcomes. However, trials evaluating various classes of other neuroprotective agents have not shown benefit to date. For the prevention of second stroke, the use of antiplatelet drugs, HMG-CoA reductase inhibitors, and angiotensin-converting enzyme inhibitors with a diuretic have shown benefit in reducing new events. In patients with underlying heart disease or atrial fibrillation, warfarin appears to be the drug of choice in preventing stroke. Early treatment of hemorrhagic stroke with calcium channel blockers can improve the functional outcome. Innovative therapies are now available for the treatment of migraine and vascular dementia. Primary prevention of stroke remains the optimal therapeutic strategy and includes treatment of systemic hypertension and hypercholesterolemia.

Adult↗