Search PubMed⌕ Search

Biomedical subjects

Jerzy Szaflik

Publications and source records attributed to Jerzy Szaflik.

At least 19 recordsLinked to original sources
PubMed2006

[Intraocular lens power calculation in patients after keratorefractive surgery--personal experience].

PURPOSE: To assess the efficacy of intraocular lens power calculation in patients with previous corneal refractive surgery. MATERIAL AND METHODS: Retrospective analysis of patients after laser refractive procedures, in whom cataract removal with phacoemulsification method was performed. Corneal power, which in conventional measurements after refractive surgery tends to increase value and results in postoperative hyperopic shift, were calculated with five methods, and the results were compared. To asses IOL power SRK/T formula was used. RESULTS: Mean spherical equivalent three months after procedures according to target refraction in examined patients ranged from -1.00 to +1.75 D. The difference between obtained and target refraction in 55% of patients ranged from -0.50 to +0.50, and in 77% from -0.75D to +0.75D. Best results were obtained in calculations performed with Rossa method. The least effective appeared to be traditional IOL power calculation method without correcting factors. CONCLUSIONS: In patients after laser correction of myopia, value of the measured keratometry should always be corrected. The most effective is Rosa method in combination with SRK/T calculation algorithm.

Adult↗
PubMed2005

[Prevalence of Kayser-Fleischer ring in patients with Wilson's disease].

The aim of the study was to assess prevalence of Kayser-Fleischer ring in children with Wilson's disease. 36 patients aged 7-17 years were enrolled into the study. All of them underwent ophthalmic examination by slit-lamp biomicroscopy. Kayser-Fleischer ring was found in 2 children (5.6%)--16 years old boy and girl with liver insufficiency. In addition, the girl had neurological symptoms. After 2 years of treatment K-F ring was not detected in the girl's eyes. Our data indicate that Kayser-Fleischer ring is rare in children and its absence does not exclude diagnosis of Wilson's disease.

Adolescent↗
PubMed2005

[Intraoperative choroidal hemorrhage in patient with Osler-Rendu syndrome].

UNLABELLED: The authors describe a 79-year-old man with Osler-Rendu-Weber syndrome, who developed intraoperative choroidal hemorrhage in left eye. During phacoemulsification under local anesthesia, shallowing of the anterior chamber was observed. Acetazolamide was administered and peribulbar block performed. Phacoemulsification was continued and intraocular lens implanted. Five months postoperatively resolution of the choroidal hemorrhage was observed. Best corrected visual acuity was 0.5. Patient developed retinal embolism in his right eye 16 years earlier. CONCLUSIONS: (1) Choroidal hemorrhage may occur more commonly in patients with Osler-Rendu-Weber syndrome. Recognition of this possible association and institution of appropriate intraoperative precautions may facilitate a good visual outcome. (2) Paradoxical embolization (stroke, retinal embolism) is the most serious consequence of hereditary hemorrhagic telangiectasia.

Aged↗
PubMed2005

[Retrospective evaluation of risk factors for graft rejection in patients after corneal transplantation performed at the Eye Clinic in the years 2001-2003].

The aim of the study was retrospective evaluation of risk factors for graft rejection in patients after corneal transplantation performed in Department of Ophthalmology in years 2001-2003. 349 cases of penetrating keratoplasty, lamellar, or penetrating with limbal graft, were analyzed. Deep stromal vascularization, anterior synechiae, the use of topical glaucoma medications, previous inflammations in anterior segment of the eye and surgical procedures were evaluated. Period from transplantation to rejection, number of relapses of rejection and changes of visual acuity were also estimated. Corneal graft rejection occurred more frequently in patients with one or more risk factors, particularly deep stromal vascularization, the use of topical glaucoma medications and in young age.

Corneal Transplantation↗
PubMed2005

[Current trends in glaucoma surgery].

The aim of this paper is presentation of new methods of laser and surgery treatment for glaucomatous patients, mainly no perforating operations: deep sclerectomy and viscocanalostomy and new modifications of known very well trabeculectomy.

Glaucoma↗
PubMed2005

[Accuracy of the SRK II, SRK/T, Holladay and Hoffer Q IOL power calculation formulas in hyperopic patients after phacoemulsification].

PURPOSE: Comparison of the SRK II, SRK/T, Holladay and Hoffer Q formulas accuracy, in calculating IOL power in hyperopic patients. MATERIAL AND METHODS: 34 eyes of 22 hyperopic patients, 15 women and 7 men, at the age from 19 to 85 years old, after phacoemulsification with PCIOL implantation, operated between 1998 and 2004 were analysed retrospectively. The power of IOL was calculated using the SRK/T formula and ranged from 28.5 to 35.0 D. The axial length ranged from 19.6 mm to 21.99 mm. The obtained refraction was measured with autorefractometer from 9 days to 37 month after operation, mean 6 month. In addition, the theoretical target refraction for the implanted IOL was calculated using the SRK II, Holladay and Hoffer Q formulas and the differences between the target and obtained refraction for all the formulas were compared. RESULTS: The best accuracy of IOL power calculation was obtained with the Hoffer Q formula. The Holladay, SRK/T and SRK II formulas gave worse results respectively. CONCLUSIONS: For the purpose of IOL power calculation in hyperopic patients the Hoffer Q or Holladay formula should be chosen from those mentioned above. Nevertheless, miscalculation exceeding 3D also happens in case of using them. The use of SRK II and SRK/T is not recommended. To improve the results other formulas utilising precise measurements of the anterior segment should be applied. If it is impossible then attention should be paid to improving traditional biometry measurements.

Adult↗
PubMed2004

Therapeutic use of a silicone hydrogel contact lens in selected clinical cases.

PURPOSE: To evaluate a silicone hydrogel contact lens as a continuous-wear bandage in selected clinical cases, a prospective, open, nonrandomized clinical study was conducted. METHODS: Seventy eyes from 70 patients with anterior segment conditions for which therapeutic lenses were indicated were enrolled in the study. In most patients (47 eyes, 67%), the presenting condition was bullous keratopathy. Patients were fitted with a lotrafilcon A silicone hydrogel lens (Focus Night & Day) that was worn continuously for 7 to 30 days, and the concomitant therapies were used. The corneal condition was assessed, and subjective comfort was recorded for 7 days to 18 months after fitting (mean follow-up, 69 days). RESULTS: Of 70 eyes, 64 (91%) showed improvement in the clinical condition of the eye, and 66 (94%) rated comfort when wearing the lens as very good or good. CONCLUSIONS: The study lens was found to be an effective and well-tolerated bandage lens in these selected patients.

Adult↗
PubMed2004

Therapeutic use of a lotrafilcon A silicone hydrogel soft contact lens as a bandage after LASEK surgery.

PURPOSE: Soft contact lenses may be used as a bandage after corneal refractive surgery. Silicone hydrogel contact lenses offer the advantage of increased oxygen permeability over conventional hydrogel lenses for this application. To evaluate a silicone hydrogel contact lens as a continuous wear bandage applied after laser-assisted sub-epithelial keratomileusis (LASEK). METHODS: We conducted a prospective, open-label, non-randomized clinical trial involving thirty patients treated with unilateral LASEK. Patients were fitted with a lotrafilcon A (Focus NIGHT & DAY; CIBA Vision, Duluth, GA) silicone hydrogel soft contact lens that was worn continuously for 3 to 4 days post-operatively. Lens movement and slitlamp evaluations of conjunctival hyperemia 1, 2, and 3 days after surgery (DAS) were recorded, as was the condition of the corneal epithelium after lens removal. Subjective comfort was rated by the patients along with the presence of symptoms or pain. RESULTS: Post-blink lens movement was evaluated by investigators as "very good" or "good" in 87% of eyes at 1 DAS, in 73% at 2 DAS, and in 60% at 3 DAS. Conjunctival hyperemia was assessed as normal or trace in 96% of eyes at 1 DAS, in 76% at 2 DAS, and in 67% at 3 DAS. An average of 80% of eyes showed normal or trace conjunctival hyperemia during the trial. The condition of the corneal epithelium after contact lens removal was rated as "very good" in 13% or "good" in 73% of eyes. An average of 77% of subjects reported "very good" or "good" comfort during the trial. Symptoms or pain were rated as "absent" or "mild" by all subjects at 1 DAS and 2 DAS and by 96% at 3 DAS. An average of 99% rated symptoms or pain as either "absent" or "mild" during the trial. CONCLUSIONS: The lotrafilcon A lens was found to be an effective and well-tolerated bandage lens after LASEK.

Adult↗
PubMed2004

Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone.

Angiogenesis, the process of new blood vessel formation, is the key event in the mechanism of several pathological processes including diabetic retinopathy. The physiological control of angiogenesis depends on the balance between stimulatory and inhibitory factors. Therefore, a number of anti-angiogenic approaches has been developed, many of them based on the inhibition of the functional activity of pro-angiogenic factors. The aim of the present study was to compare the anti-angiogenic effectiveness of sulindac sulfone and some herbal compounds in the serum-induced angiogenesis test performed in Balb/c mice. Pooled sera from 35 patients with diabetes type 2 and retinopathy were used as pro-angiogenic stimuli. The strongest inhibitory effect was observed for the sulindac sulfone and ursolic acid in the highest concentration of 200 micro g/ml, as well as for the low-dosage concomitant treatment with 2 micro g/ml of epigallocatechin gallate (EGCG, green tea flavanol), ursolic acid (plant-derived triterpenoid), sulindac sulfone and convalamaroside (steroidal saponin). Combination treatment was significantly more effective than monotherapy with medium (20 micro g/ml) or lowest doses of tested compounds. The present study is the first to demonstrate the potent anti-angiogenic effect of the combination therapy comprising of plant-derived extracts and sulindac sulfone, as tested in the in vivo angiogenesis experimental model with sera of non-proliferative diabetic retinopathy patients used as the pro-angiogenic stimuli. We think that it might be the first step toward application of some of these compounds, in the future, in preventive anti-angiogenic therapy of these patients, as well, as in the treatment of later, proliferative stage of this disease.

Angiogenesis Inducing Agents↗
PubMed2004

[Intraoperative use of mitomycin C in glaucoma filtering surgery--indications, results and complications].

PURPOSE: The influence of MMC on the cornea, especially on the corneal endothelium and thickness, were checked. MATERIAL AND METHODS: In one-year-follow up patients after trabeculectomies with or without topical use of mitomycin C were controlled for early and late complications, and levels of intraocular pressure. The progression of glaucomatous neuropathy was obtained by comparing the cup to disc ratio and some parameters of static visual field testing (MD, PSD) progressions, after one year observations. RESULTS: Intraocular pressures were stable and at lower levels in the group of patients after primary trabeculectomies (group C) than in the control group (group A). We obtained good, statistically significant decrease in IOP in all groups during one year follow-up. CONCLUSIONS: We didn't find any toxic effects of MMC, given on a sponge during trabeculectomy, on the morphology and physiology of the corneal endothelium and the central corneal thickness. We also didn't note any differences between groups in the progression of glaucomatous optic nerve damaged and cataract after 1 year follow up.

Adult↗
PubMed2004

[Risk factors for encapsulated filtering bleb after trabeculectomy--own experience].

The aim of the study was to evaluate the incidence of encapsulated filtering bleb at patients after trabeculectomy. We analyzed risk factors, prognosis and treatment in cases of this complication. All 857 cases of trabeculectomies performed in Department of Ophthalmology of Medical University of Warsaw in years 2001-2003 were included in the study. Twenty two cases (2.5% of all trabeculectomies) of encapsulated filtering bleb were analyzed. Twenty patients (91%) underwent surgery procedure and two patients (9%) were treated medically. The encapsulated filtering blebs occurred mainly in patients after previous ocular surgery, in eyes with episodes of earlier ocular inflammation and in patients treated with many antiglaucoma drops.

Aged↗
PubMed2004

[Diode laser cyclophotocoagulation--effect on intraocular pressure in comparison with cyclodiathermy under the scleral flap].

UNLABELLED: The aim of this study was to retrospectively analyze intraocular pressure and state of the eyeball in patients treated with diode laser, and to compare the outcomes with a group of patients after cyclodiahtermy under the scleral flap. We analyzed: visual acuity, IOP, percentage of lowering the IOP from the beginning, subjective patients' feelings of pain and complications. CONCLUSIONS: TSCPC is safe for patients and may be repeated, if needed. Laser cyclodestruction gives new possibilities in noninvasive IOP lowering with less complications than cyclodiahtermy, without changes in patient's visual functions.

Aged↗
PubMed2004

[Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients].

PURPOSE: To establish the efficacy and safety of timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination, each given twice daily, in primary open-angle glaucoma and ocular hypertensive patients. MATERIAL AND METHODS: In this prospective, multicenter, double-masked trial, 37 patients were treated twice daily with timolol for 4 weeks. Then, they were randomized to one of the treatment medications for 6 weeks, after which they were treated with timolol again for 2 weeks before placed on the opposite treatment medication for 6 weeks. RESULTS: A total of 36 patients completed the trial. The mean baseline intraocular pressure (IOP) was 22.3 +/- 3.7 mmHg. Following 6 weeks of treatment, the mean decrease of IOP was 18.0 +/- 2.2 mmHg for timolol/dorzolamide combination and 17.4 +/- 2.0 for timolol/pilocarpine combination. The mean diurnal curve IOP was 18.1 +/- 2.2 mmHg for timolol/dorzolamide group and 16.7 +/- 1.9 mmHg for timolol/pilocarpine group. These differences were statistically significant. Statistically more patients reported ocular pain and diminished vision during use of the timolol/pilocarpine combination. CONCLUSIONS: This study suggest that timolol 0.5%/pilocarpine 2% fixed combination can provide at least similar efficacious reduction in IOP as timolol 0.5 %/dorzolamide 2% fixed combination in patients with primary open-angle glaucoma and ocular hypertension.

Adrenergic beta-Antagonists↗
PubMed2004

[The reasons for the false positive diagnosis of glaucoma].

Glaucoma, if left untreated, leads to blindness, but if detected early, disease progression can be stopped or slowed with drugs or surgical treatment. The development of existing and new diagnostic methods has allowed substantial improvement in the clinical detection of possible glaucoma. But in some cases false positive diagnoses can be undertaken. In this paper we discussed reasons for the wrong evaluation of factors suggesting the diagnosis of glaucoma, with special interest for mistakes in applanation tonometry results caused by thick cornea.

Cornea↗
PubMed2004

[Angiogenic activity and VEGF level in sera of diabetic patients with non-proliferative retinopathy].

Diabetic retinopathy is one of the most common causes of blindness. The majority of studies concerning this problem were performed in patients with late stage of disease, demonstrating proliferative retinopathy, when malformations of retinal vessels became irreversible. Numerous angiogenic factors related to retinal angiogenesis have been described. Among them, VEGF is thought to be the major mediator of proliferative retinopathy. Our present study was performed on sera collected from patients with earlier stage of ocular complications, manifested as background retinopathy. We have believed that the knowledge of the earliest events leading to pathological angiogenesis may be valuable for establishing some prophylactic regimens. Sera of 22 persons with DM1, aged 33-70 years, 37 persons with DM2, aged 37-79 years, 51 healthy people, aged 22-80 years (as controls) were studied. Direct serum-induced cutaneous angiogenesis test in mice (SIA) was applied. VEGF concentration in sera was mesured by ELISA (R & D Systems) test. Angiogenic activity and VEGF concentration of DM1 patients sera were highly statistically lower than these parameters in DM2 patients and controls.

Adult↗
PubMed2004

[Proteinases inhibitors in sera of diabetic patients with non-proliferative retinopathy].

Diabetes is associated with a hypercoagulable state. Eighty percent of patients with diabetes mellitus die due to various thrombotic vascular complications. Disorder of coagulation and fibrynolysis is associated with diabetic retinopathy and nephropathy. Angiogenesis requires degradation of vascular basement membrane prior to migration and proliferation of endothelial cells. Various serine proteases play important role in this process. The homeostatic system is also the source of endogenous inhibitors of angiogenesis. Human serum contains various factors able to induce or suppress formation of new blood vessels. The aim of the present study was to evaluate the activity of some angiogenesis inhibitors, anti-proteases, anti-thrombin III, a1 anti-trypsin and a2 anti-plasmin in sera of patients with diabetes mellitus type 1 and 2 and non-proliferative retinopathy, and to correlate this activity to total angiogenic potential of these sera, measured by mice cutaneous test. Sera of 22 persons with DM1, aged 33-70 years, 35 persons with DM2, aged 37-79 years, and 51 healthy people, aged 22-80 years (as control group) were studied. Direct serum-induced cutaneous angiogenesis test in mice (SIA) was applied. Berichrom (ade Behring) tests and immunoturbidimetric method were used for evaluation of anti-proteases activity. Angiogenic activity of DM1 patients sera was statistically lower than this parameter in DM2 patients and in control group. Levels of anti-proteases were similar in DM1, DM2 and control group, with one exception: anti-thrombin level was lower in DM2 patients' sera than this in the control group. Analysis of correlation revealed important difference in behaviour of DM1 sera, as compared to other groups. Significant negative correlation was observed between angiogenic activity and anti-thrombin, as well as anti-trypsin level of DM1 patients' sera. On the other hand, correlation analysis performed for the sera of control group revealed significant positive correlation between their angiogenic activity and anti-thrombin level. No other correlations were found.

Adult↗
PubMed2004

[The analysis of refractive error in children and adolescents from 6-15 years of age based on 1000 examinations in two major Polish regions].

PURPOSE: The aim of this study is to present the results of screening examinations of refractive errors, taken on 1002 of school children ranging from 6 to 15 years of age. MATERIAL AND METHODS: As the result of Internet screening visual acuity and color perception tests named "I can see..." in 10,021 children from randomly chosen schools in Poland in the year 2002, the group of 1002 children was chosen. In this group, the subjective and objective refractive error examination was taken as well as the visual acuity test, color perception with the use of Ishihara tables and full ophthalmologic examination. RESULTS: Average visual acuity was RE: 0.72 (SD +/- 0.31) and LE: 0.72 (SD +/- 0.31). The prevalence of emmetropia was 34%. In the examined group myopia in 17%, hyperopia in 20%, astigmatism in 5.5% of children was found, and in 24.5% of patients complex errors occur such as myopic and hyperopic astigmatism.

Adolescent↗