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Biomedical subjects

Jerry A Shields

Publications and source records attributed to Jerry A Shields.

168 records · Page 10Linked to original sources

Giant nodular posterior scleritis simulating choroidal melanoma and birdshot retinochoroidopathy.

A case of nodular posterior scleritis simulating both a choroidal tumor and birdshot chorioretinopathy is described. Fluorescein angiography, indocyanine green angiography, and ultrasound were performed. Results of laboratory tests were normal, including HLA-A29, erythrocyte sedimentation rate, rheumatoid factor, and antinuclear antibodies. A chest x-ray was normal. A diagnosis of nodular posterior scleritis was made and the minimally symptomatic patient without ocular pain was observed unless symptoms progressed. In this case, certain clinical features led to the proper diagnosis.

Adult↗

Differentiation of pigmented conjunctival squamous cell carcinoma from melanoma.

A 69-year-old man developed a pigmented conjunctival tumor that had a papillomatous vascular configuration but no leukoplakia. Although the pigmentation suggested melanoma clinically, histopathologic study of the resected lesion disclosed squamous cell carcinoma, with scattered dendritic melanocytes in the tumor. Conjunctival squamous cell carcinoma can be pigmented, similar to melanoma. The papillomatous arrangement of blood vessels in such tumors should strongly suggest squamous cell carcinoma despite the absence of leukoplakia.

Aged↗

Enophthalmos as initial manifestation of occult, mammogram-negative carcinoma of the breast.

A patient with enophthalmos was found to have occult metastatic breast carcinoma to the orbit despite normal findings on breast examination and mammogram. Enophthalmos can be a sign of serious systemic disease and should be appropriately investigated. Despite radiologically interpreted normal orbital and breast imaging, the clinician should rule out underlying subclinical malignancy and consider orbital biopsy.

Aged↗

Changing concepts in management of circumscribed choroidal hemangioma: the 2003 J. Howard Stokes Lecture, Part 1.

BACKGROUND AND OBJECTIVE: To review trends in the management of circumscribed choroidal hemangioma (CCH) and to propose treatment guidelines based on review of recent literature and the authors' personal experience with more than 250 METHOD: The English-language literature on the management of CCH was reviewed, with emphasis on changing concepts in recent years. RESULTS: Xenon arc and argon laser photocoagulation and thermotherapy have been used to treat CCH with localized retinal detachment, but there has recently been enthusiasm for photodynamic therapy (PDT) using fluorescein angiography and optical coherence tomography to monitor subretinal fluid and cystoid retinal edema before and after treatment. Tumors with extensive retinal detachment have been managed by surgical attempts at retinal reattachment followed by photocoagulation or cryotherapy, and more recently by radiotherapy. Management currently includes observation, argon laser photocoagulation, transpupillary thermotherapy, PDT, and radiotherapy. Enucleation may be necessary in rare cases. The goal of treatment should be to induce resolution of existing retinal detachment and to improve or stabilize visual loss. CONCLUSIONS: There is increasing use of PDT for CCH with localized retinal detachment and radiotherapy for CCH with more extensive detachment. Although follow-up is short, current methods may achieve better tumor control and better visual outcome. However, caution is advised because long-term follow-up is still not available.

Choroid Neoplasms↗

Resolution of advanced cystoid macular edema following photodynamic therapy for choroidal hemangioma.

A 45-year-old man was referred for 2 months of decreasing vision in his left eye. His visual acuity was 20/200 secondary to a subtle juxtapapillary choroidal hemangioma producing profound cystoid macular edema, with the affected retina measuring 330 microns thick by optical coherence tomography. Due to the severe cystoid macular edema, visual prognosis was judged to be poor. One month following photodynamic therapy to the tumor using verteporfin, the cystoid macular edema completely resolved, foveal anatomy returned to normal, optical coherence tomography thickness was 179 microns, and visual acuity recovered to 20/25. Photodynamic therapy of choroidal hemangioma may be effective in resolving associated cystoid macular edema and improving visual acuity.

Choroid Neoplasms↗

Laser ablation of an enlarging small melanocytic choroidal tumor: 16-year follow-up and rationale for treatment.

Results of laser photocoagulation of a growing pigmented choroidal lesion for which the differential diagnosis included enlarging nevus and small melanoma and the rationale for such treatment are described. A 37-year-old woman underwent ablative laser photocoagulation for a small juxtapapillary pigmented choroidal lesion that was documented photographically to enlarge in diameter from 300 to 1,750 microns after 8 years. Sixteen years after laser photocoagulation, the visual acuity remains 20/20 with no further growth or recurrence of the lesion. Local treatment may be justified for a small pigmented choroidal lesion that is documented to grow.

Adult↗