Biomedical subjects

Jeong Sook Park

Publications and source records attributed to Jeong Sook Park.

13 recordsLinked to original sources

PubMed2006

The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder.

This study examined the possibility of using a tissue cultured root of wild Panax ginseng (tcwPG) as a fertility agent. The effect of tcwPG on spermatogenesis was studied using male rats. The tcwPG crude powder was administered orally to 7-week-old rats over a 6-week period. The number of sperm in the testes and epididymides was significantly higher than the control. A histological examination did not reveal any morphological changes in the testes from the tcwPG powder treated rats. Moreover, there were no significant differences in the weights of the heart, spleen, liver, kidney, brain, testes and epididymides. Oligospermia was also induced by administering 2,3,7,8-tetrachlorodaibenzo-p-dioxin (TCDD) to the rats in order to estimate the feasibility of using tcwPG as treatment for infertility caused by spermatogenic disorders. After exposing the rats to TCDD, the tcwPG saponin fraction treated rats showed some improvement in the body weight, sperm number and testis morphology. It was estimated that tcwPG had feasibility as a therapeutic agent on spermatogenic disorder.

Animals↗

PubMed2006

[The effects of Dogbi(ST35) & Sulan moxibustion on knee joint pain, range of motion and discomfort during ADL in the aged].

PURPOSE: The purpose of this research was to test the effects of ST35 & Sulan moxibustion on knee joint pain, range of motion, and discomfort during Activies of Daily Living (ADL) in elderly with knee joint pain. METHOD: A nonequivalent control group pre-post test research design was used. Thirty four elderly who had knee joint pain were studied. Of them, sixteen were in the experimental group and eighteen the control group. The instruments used for this study were NRS, goniometer, and a modified ADL questionnaire developed by Lee. RESULT: The pain scores of right & left knee joint after moxibustion were significantly different between the experimental group and the control group (Right: F=26.27, p=0.000, Left: F=20.77, p=0.000). Right and left knee ROM scores were significantly different between the experimental group and the control group after moxibustion (Right: F=10.74, p=0.003, Left: F=9.239, p=0.005). Discomfort during ADL scores were significantly different between the experimental group and the control group after moxibustion (F= 32.31, p=0.000). CONCLUSION: It is necessary that nurses provide the elderly with knee joint pain with moxibustion to reduce joint pain and to increase knee ROM as an alternative therapy.

Activities of Daily Living↗

PubMed2006

[The effect of an exercise program on body composition and physical fitness in obese female college students].

PURPOSE: This study was done to analyze the effects of an exercise program on body composition and physical fitness of obese female college students. METHOD: Data was collected from September 29, 2003 to December, 29, 2003. The research design was a randomized control group pretest-posttest experimental design. The subjects were college nursing students at K University. Forty four students, 20 in the experimental group and 24 ina control group, with more than 30% body fat were randomly assigned. The subjects in the experimental group participated in an exercise program for 12 weeks, sixty minutes per session, five times per week. Body composition and physical fitness was measured by a body composition analyzer, cardiovascular endurance, muscle endurance, muscle strength(grip strength, back strength), flexibility, balance, agility(whole body reaction time) and power(standing long jump). RESULT: Body weight(F=4.76, p=0.035), body fat(kg)(F=5.68, p=0.022) and body mass index(F=5.73, p=0.021) of the experimental group were significantly different from the control group, but there were no significant differences in body fat(%), lean body mass, muscle mass and WHR. Back strength(F=6.50, p=0.015), flexibility(F=14.62, p=0.000), muscle endurance(F=7.98, p=0.007), power(F=5.76, p=0.021) and balance(F=2.46, p=0.018) of the experimental group were significantly different from the control group, but there were no significant differences in cardiovascular endurance, grip strength or agility. CONCLUSION: The exercise program was effective in improving body weight, body fat(kg), body mass index, back strength, muscle endurance, flexibility, balance and power of obese female college students.

Adolescent↗

PubMed2006

[Development and application of an online alternative therapy and health promotion class].

PURPOSE: This study was to develop an online "alternative therapy and health promotion" class for university students and to evaluate its changes. METHOD: The online class was developed based on the Instructional Systems Development (ISD) model and model of Web-Based Instruction (WBI) developmental process. This was a quasi- experimental, one group pretest-posttest design. The subjects of this study were 130 students in 3 universities, and they were provided the cyber class for 16 weeks. Data was analyzed by descriptive and plural answer statistics, and paired t-test. RESULTS: The cyber class was developed in five steps: analysis, design, data collection and reconstruction, programming and publishing, and evaluation. The results of program evaluation were positive, which included learning 3.47, system 3.57, and learning satisfaction 3.64 on the scale of 5. The posttest scores of cognition and reliability of alternative therapy were higher than pretest scores. The posttest scores of health promoting lifestyle (t=-5.051, p=.000) and perceived health status (t=2.979, p=.003) were significantly higher than those of the pretest. CONCLUSION: These results suggest that the cyber class is a positive method in increasing a cognition, reliability of alternative therapy, and is effective to improve a health promotion lifestyle and perceived health status for the university students.

Complementary Therapies↗

PubMed2006

Knowledge discovery in nursing minimum data set using data mining.

PURPOSE: The purposes of this study were to apply data mining tool to nursing specific knowledge discovery process and to identify the utilization of data mining skill for clinical decision making. METHODS: Data mining based on rough set model was conducted on a large clinical data set containing NMDS elements. Randomized 1,000 patient data were selected from year 1998 database which had at least one of the five most frequently used nursing diagnoses. Patient characteristics and care service characteristics including nursing diagnoses, interventions and outcomes were analyzed to derive the meaningful decision rules. RESULTS: Number of comorbidity, marital status, nursing diagnosis related to risk for infection and nursing intervention related to infection protection, and discharge status were the predictors that could determine the length of stay. Four variables (age, impaired skin integrity, pain, and discharge status) were identified as valuable predictors for nursing outcome, relieved pain. Five variables (age, pain, potential for infection, marital status, and primary disease) were identified as important predictors for mortality. CONCLUSIONS: This study demonstrated the utilization of data mining method through a large data set with standardized language format to identify the contribution of nursing care to patient's health.

Adult↗

PubMed2006

[Comparison of glass particle contamination according to method of ampule cutting and needle aspiration].

PURPOSE: Glass particle contamination of the contents of single-dose glass ampules can occur upon opening. Different aspiration techniques, different sizes of needles, different sizes of ampules, and different cutting methods were studied to determine if they had any effect on glass particle contamination. METHOD: Different aspiration techniques(with filter, without filter), different sizes of needles(18G, 25G), different sizes of ampules(2 ml, 20 ml), and different cutting methods (with cotton, without cotton) were evaluated. METHOD: Twenty ampules were randomly assigned in each group. Three slides containing glass particles for each ampule were made and counted under a microscope by 3 study blind persons. RESULT: The number of glass particle contamination is much less when using a filter rather than without a filter. The number of glass particle contamination is much less when using a 25G needle rather than on 18G needle. The number of glass particle contamination is much less when using 2 ml ampules rather than 20 ml ampules. The number of glass particle contamination is much less when using cotton rather than without cotton. CONCLUSION: It was shown that using a filter, a small size needle, smaller sized ampules and using cotton when cutting the ampule will decrease the risk of parenteral injection of glass particles.

Drug Contamination↗

PubMed2006

[Evaluation of a virtual class on lifelong health care for women].

PURPOSE: This study was to evaluate a virtual class, 'lifelong health care for women', for female university students. METHOD: The research design was one group pre-post design. A pretest and posttest were conducted to measure CMI, perceived health status, health promoting lifestyle, and knowledge related to women's health. The subjects of this study were 74 female students in 3 universities, and they were provided with the virtual class by K university consortium for 16 weeks. Data was analyzed by descriptive and paired t-test. RESULTS: There were statistically significant differences in CMI (t=3.367, p=.001), perceived health status (t=-2.788, p=.007), and knowledge related to women's health (t=-10,432, p=.000) between the pretest and posttest. However, there was not a statistically significant difference in a health promoting lifestyle (t=-1.431, p=.157) between the pretest and posttest. CONCLUSION: These results suggest that a virtual class on lifelong health care for women is an effective method in decreasing health problems, and improving perceived health status and knowledge related to women's health by female university students.

Adult↗

PubMed2005

[The effects of a health promotion program in rural elderly on health promotion lifestyle and health status].

PURPOSE: The purpose of this study was to identity the effects of a health promotion program for rural elderly on health promotion lifestyle and health status. METHOD: The study was a nonequivalent control group pre-post experimental design. Data collection was performed from April 12th, 2003 to August 2nd, 2003. The subjects were selected at Mari Myun Geochang Gun in Korea. 44 elders were in the experimental group and 45 elders were in the control group. The 16-week health promotion program was given to the experimental group. Data was analyzed by descriptive statistics, chi(2)-test, t-test, and ANCOVA test with SPSS/Win 10.0 program. RESULT: The experimental group showed higher scores of a health promotion lifestyle and perceived health status than the control group. In addition, systolic BP, heart rate, body fat and glucose of the experimental group were lower than the control group. Waist flexibility, left hand grip power, back strength and leg strength of the experimental group were higher than the control group. However, there were no significant differences in diastolic BP, total cholesterol and right hand grip power between the two groups. CONCLUSION: This health promotion program for rural elderly can be recommended as an effective nursing intervention in rural communities.

Aged↗

PubMed2004

[The effect of drug abuse prevention program for elementary school students].

PURPOSE: This study is to evaluate the effects of drug abuse prevention program for elementary school students. METHOD: The design of this study is nonequivalent control group pretest-posttest design. The subjects of experimental group were 27 students and the subjects of control group were 25 students in fifth grade of elementary school in C City, Gyeongsangbuk-do. The experimental group had Drug Abuse Prevention Program, which was two days per week program, for 5 weeks. And post-test was carried out in the same way as the pre-test. Data analysis was done using frequency, percentage, mean, standard deviation, Chi-square test, t-test, Paired Samples t-test using with SPSS WIN 11.0. RESULT: the experimental group, to which drug abuse prevention program was given, was improved in knowledge of drug and unacceptable attitude of drug compared to the control group, but there were no significant differences of self-esteem and assertiveness between two groups. CONCLUSION: The drug abuse prevention program was effective to increase knowledge and attitude of drug in elementary school students.

Child↗

PubMed2004

[The effects of an elderly health promotion program on health promotion lifestyles, health status and quality of life in the elderly].

PURPOSE: The purpose of this research was to identify the effect of an elderly health promotion program on health promotion lifestyles, health status, and quality of life in the elderly. METHOD: The research design was a nonequivalent control group pre post experimental design. Thirty two elderly persons were in the experimental group and the other thirty two elderly were in the control group. A 16 week health promotion program was given to the experimental group. The measurement tools were HPLP II, grip strength, back lift strength, flexibility, body fat percentile, blood sugar, serum cholesterol, and quality of life. RESULT: The experimental group showed a higher score of health promoting lifestyles, flexibility, grip strength, back lift strength, and quality of life. There were no differences in body fat percentiles, blood sugar and serum cholesterol between the experimental and control group. CONCLUSION: This health promotion program for elderly can be recommended as an effective nursing intervention for elderly in a community.

Aged↗

PubMed2003

Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor.

The present study was to investigate the feasibility of oral delivery of recombinant human epidermal growth factor (rhEGF). Polyethylene glycol (PEG)-coated liposomes containing rhEGF was prepared and evaluated for their stability and permeability in Caco-2 cells. In the animal study, we also determined plasma concentration and gastric ulcer healing effect after oral administration of rhEGF liposomes or the solution. Encapsulation of rhEGF into liposomes, suppressed the degradation in Caco-2 cell homogenate compared with the solution. The flux of rhEGF from dipalmitoylphosphatidylcholine (DPPC) liposome across Caco-2 cell monolayer from the apical to basolateral side was three times greater than that from phosphatidylcholine (PC) liposome or the solution. After oral administration of rhEGF liposomes or the solution in rats, the area under the concentration-time curve (AUC) of rhEGF increased 1.7- and 2.5-fold for PC and DPPC liposomes, respectively. The gastric ulcer healing effect was significantly increased in DPPC liposome compared with PC liposome and the solution. The enhanced curative ratio of rhEGF encapsulated into DPPC liposome may be due to the resistance to enzyme degradation, higher permeability and increased plasma AUC. Therefore, PEG-coated liposomes containing rhEGF could be used as an oral delivery formulation with enhanced encapsulation efficiency.

Acute Disease↗

PubMed2003

Buccal mucosal ulcer healing effect of rhEGF/Eudispert hv hydrogel.

We have studied the effect of rhEGF on the buccal mucosal ulcer healing. rhEGF was rapidly degraded upon incubation with the hamster buccal mucosal homogenates; The degradation of rhEGF was significantly inhibited by sodium lauryl sulfate (SLS). Eudispert hv hydrogel and Polycarbophil 974P hydrogel were prepared for rhEGF delivery and their mucoadhesiveness was measured by the Instron method. The mucoadhesive force of Eudispert hv was significantly greater than that of Polycarbophil 974P. Moreover, rhEGF in Eudispert hv hydrogel remained stable for about 2 months. To evaluate the ulcer healing effect of rhEGF, the buccal mucosal ulcer was induced in golden hamsters using acetic acid. At 24 h after administration of rhEGF/Eudispert hv hydrogel, the ulcerous area was decreased compared with rhEGF solution and, as a result, the curative ratio was 36.8 +/- 5.68%. By the addition of SLS (0.5%) to Eudispert hv hydrogel, the curative ratio increased 1.5 times. The mechanism of the action was probably due to a combination of protection of the drug against proteases present in mucosa and prolongation of the release of rhEGF from the formulation at the site of action.

Acetic Acid↗

PubMed2002

rhEGF/HP-beta-CD complex in poloxamer gel for ophthalmic delivery.

The purpose of the present study is to prepare chemically and physically stable rhEGF/poloxamer gel and to investigate its possibility of ophthalmic delivery. The rhEGF/HP-beta-CD complex markedly increased rhEGF stability compared with rhEGF solution at 4 degrees C. The poloxamer gel was composed of poloxamer 407 (16%) and poloxamer 188 (14%). Additive of rhEGF/HP-beta-CD complexes increased the gelation temperature and 0.5% rhEGF/HP-beta-CD complex exhibited a suitable gelation temperature (35.5 degrees C). The gel strength and bioadhesive force decreased by increasing the rhEGF and HP-beta-CD ratio from 1:4 to 1:20 in the complex. The in vitro release of rhEGF from poloxamer gel containing 1:4 rhEGF/HP-beta-CD complex was much slower than that of rhEGF solution and faster than that of 1:20 rhEGF/HP-beta-CD complex. After ocular administration of poloxamer gels in the rabbit, the concentration of rhEGF in tear declined at a first-order elimination. The poloxamer gel containing rhEGF/HP-beta-CD complex increased the area under the concentration-time curve (AUC) of rhEGF in tear fluid compared with gel containing rhEGF solution. 1:20 ratio of rhEGF/HP-beta-CD exhibited high AUC, indicating that rhEGF may be retained in the pre-corneal area for prolonged period. Therefore, the poloxamer gel could be applicable for the development of effective ophthalmic delivery.

2-Hydroxypropyl-beta-cyclodextrin↗