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Biomedical subjects

Jean-Marc Vanden-Broeck

Publications and source records attributed to Jean-Marc Vanden-Broeck.

3 recordsLinked to original sources

Gravity capillary waves in fluid layers under normal electric fields.

We study the formation and dynamics of interfacial waves on a perfect dielectric ideal fluid layer of finite depth, wetting a solid wall, when the region above the fluid is hydrodynamically passive but has constant permittivity, for example, air. The wall is held at a constant electric potential and a second electrode having a different potential is placed parallel to the wall and infinitely far from it. In the unperturbed state the interface is flat and the normal horizontally uniform electric field is piecewise constant in the liquid and air. We derive a system of long wave nonlinear evolution equations valid for interfacial amplitudes as large as the unperturbed layer depth and which retain gravity, surface tension and electric field effects. It is shown that for given physical parameters there exists a critical value of the voltage potential difference between electrodes, below which the system is dispersive and above which a band of unstable waves is possible centered around a finite wavenumber. In the former case nonlinear traveling waves are calculated and their stability is studied, while in the latter case the instability leads to thinning of the layer with the interface touching down in finite time. A similarity solution of the second kind is found to be dominant near the singularity, and the scaling exponents are determined using analysis and computations.

Journal Article↗

Monte Carlo simulation of an inhomogeneous dielectric continuum model for B-DNA.

Thermodynamic and structural properties of the counterion atmosphere surrounding B-DNA are calculated by Monte Carlo simulation in a spatially inhomogeneous, but piecewise uniform, dielectric continuum cell model - the "barbarous" model. A boundary element formulation is implemented to study the sensitivity of these properties with respect to perturbations in the location of discontinuous dielectric boundaries relative to fixed and mobile charges. High concentrations are considered corresponding to the liquid crystalline hexagonally ordered phase of DNA. Primitive model results are verified against other simulation reports and a comparison of barbarous model predictions with experimental data is discussed. The internal energy, osmotic coefficient, radial distributions and the population ratio of counterions in the geometrically resolved major and minor grooves are all found to strongly depend on the dielectric boundary position. This suggests that a self-consistent development of the model should consider a free surface problem where the boundary is not specified a priori.

Computer Simulation↗

Steady two-layer flows over an obstacle.

Nonlinear waves in a forced channel flow of two contiguous homogeneous fluids of different densities are considered. Each fluid layer is of finite depth. The forcing is due to an obstruction lying on the bottom. The study is restricted to steady flows. First a weakly nonlinear analysis is performed. At leading order the problem reduces to a forced Korteweg-de Vries equation, except near a critical value of the ratio of layer depths which leads to the vanishing of the nonlinear term. The weakly nonlinear results obtained by integrating the forced Korteweg-de Vries equation are validated by comparison with numerical results obtained by solving the full governing equations. The numerical method is based on boundary integral equation techniques. Although the problem of two-layer flows over an obstacle is a classical problem, several branches of solutions which have never been computed before are obtained.

Computer Simulation↗