Biomedical subjects

Jean-Jacques Daudin

Publications and source records attributed to Jean-Jacques Daudin.

4 recordsLinked to original sources

PubMed2005

Alcohol and atherosclerotic vascular disease risk factors in French men: relationships are linear, J-shaped, and U-shaped.

BACKGROUND: Although it is well admitted that alcohol displays a U-shaped relationship with atherosclerotic vascular disease, individual relationships between alcohol and atherosclerosis risk factors may be different and have not been determined precisely for several of them. METHODS: A cross-sectional study within the SU.VI.MAX French cohort study was performed to assess the curve of potential relationships between alcohol and atherosclerosis risk factors in 2126 healthy men. Mean daily alcohol intake was derived from 37 alcoholic beverages in twelve 24-hr dietary recalls. Logistic models were adjusted for age. RESULTS: Apolipoprotein B (ApoB), fasting glucose, body mass index, waist-to-hip ratio, and waist circumference displayed a linear relationship with alcohol. The odds ratios and 95% confidence intervals associated with abnormal values of the markers for the highest quintile of alcohol intake were 1.45 (1.06-1.97) for ApoB, 1.98 (1.40-2.80) for fasting glucose, and 1.74 (1.30-2.34) for body mass index. An inverse J-shaped relationship was assumed for ApoA1 and ApoB/ApoA1 ratio, whereas a U-shaped relationship was observed for serum triglycerides and mixed hyperlipidemia. Only the highest quintile of alcohol was associated with hypertension, although the test for linearity was also significant. No association was observed for Lp(a) or homocysteine. Associations were unmodified by further adjustment for carbohydrates, fiber, lipids, tobacco, or exercise. CONCLUSIONS: The aggregate of the disparate alcohol risk factor relationships suggests probable net benefit at 15 to 25 g of alcohol/day.

Alcohol Drinking↗

PubMed2004

Spotting effect in microarray experiments.

BACKGROUND: Microarray data must be normalized because they suffer from multiple biases. We have identified a source of spatial experimental variability that significantly affects data obtained with Cy3/Cy5 spotted glass arrays. It yields a periodic pattern altering both signal (Cy3/Cy5 ratio) and intensity across the array. RESULTS: Using the variogram, a geostatistical tool, we characterized the observed variability, called here the spotting effect because it most probably arises during steps in the array printing procedure. CONCLUSIONS: The spotting effect is not appropriately corrected by current normalization methods, even by those addressing spatial variability. Importantly, the spotting effect may alter differential and clustering analysis.

Animals↗

PubMed2004

Drinking patterns in French adult men--a cluster analysis of alcoholic beverages and relationship with lifestyle.

BACKGROUND: Establishing patterns of alcohol consumption may be useful for investigating the relationship between alcohol and diseases. METHODS: We used a hierarchical agglomerative clustering method to describe the intake of eight types of alcoholic beverages and to determine drinking patterns in a cohort of 1797 men enrolled in a French 8-year intervention study involving nutritional doses of vitamins and minerals, the SU.VI.MAX study. RESULTS: Cluster 1, referred to as 'abstainers', was defined a priori and included 329 men who drank less than 5 g of alcohol per day. Six drinking patterns were defined in alcohol drinkers, with increasing mean alcohol intake: cluster 2, 'low drinkers', included 670 subjects, who drank little of any type of alcoholic beverage; cluster 3, 'high quality wines', included 584 men with a high intake of champagne, high quality wines, and high-alcohol aperitifs; cluster 4, 'beer and cider', included 190 subjects with a high intake of beer and cider; cluster 5, 'digestives', included 54 men with a specifically high consumption of digestive beverages; cluster 6, 'local wines', included 238 subjects with a high intake of local wines and low-alcohol aperitifs; cluster 7, 'table wines', included 61 men with a high intake of table wines and high-alcohol aperitifs. These clusters were significantly associated with socioeconomic and lifestyle variables such as place of residence, occupation, mean caloric intake and distribution of energy intake throughout the day, body mass index, and smoking habits. CONCLUSIONS: They will be useful in future studies of the relationship between alcohol intake and medical conditions or risk factors.

Alcohol Drinking↗

PubMed2003

Homogeneity check of agricultural and food industries samples using near infrared spectroscopy.

Samples distributed in proficiency testing schemes (PTS) need to be homogeneous in order to be sure that if a laboratory has a result different from the other laboratories, its error can be attributed to its analysis method and not to its sample. This control must be done according to the ISO 13528 draft standard before sending the samples to the laboratories. It can be done by determining homogeneity targets by sub-contracting to accredited laboratories using reference methods, but this engenders logistic and financial problems. That is why a homogeneity check using Near Infrared Spectroscopy (NIR) has been developed for agricultural and food industries samples prepared for PTS at Bipea (Bureau Interprofessionnel d'Etudes Analytiques). To evaluate the homogeneity among samples, this procedure involves a comparison of NIR spectra, the determination of global homogeneity criteria and the use of control charts. The method of control developed and carried out at Bipea allows the rapid and easy monitoring of the performance of the sample preparation.

Crops, Agricultural↗